6-Propoxy-1,3-dihydro-indol-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 6-Propoxy-1,3-dihydro-indol-2-one
• 英文别名: 6-Propoxy-1,3-dihydroindol-2-one；6-propoxy-1,3-dihydroindol-2-one
• 化学式: C₁₁H₁₃NO₂
• 分子量: 191.23
• InChiKey: AWGUZAPCSUINFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-Propoxy-1,3-dihydro-indol-2-one 、 3,4,5-三甲氧基苯甲醛 在 哌啶 作用下， 以 乙醇 为溶剂， 以62%的产率得到6-Propoxy-3-[1-(3,4,5-trimethoxy-phenyl)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one
  参考文献：
  名称：

  Structure–activity-relationship studies of conformationally restricted analogs of combretastatin A-4 derived from SU5416

  摘要：

  A series of combretastatin A-4 analogs derived from the ATP competitive, VEGF receptor tyrosine kinase inhibitor, SU5416 were synthesized. The cytotoxic effects of the analogs were evaluated against PC-3 and MDA-MB-231 cancer cell lines, as well as their abilities to inhibit tubulin polymerization. Results are compared to those of compound 1, our lead compound previously reported. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.06.017

文献信息

• Structure–activity-relationship studies of conformationally restricted analogs of combretastatin A-4 derived from SU5416
  作者：Bulbul Pandit、Yanjun Sun、Ping Chen、Dan L. Sackett、Zhigen Hu、Wendy Rich、Chenglong Li、Andrew Lewis、Kevin Schaefer、Pui-Kai Li

  DOI：10.1016/j.bmc.2006.06.017

  日期：2006.10

  A series of combretastatin A-4 analogs derived from the ATP competitive, VEGF receptor tyrosine kinase inhibitor, SU5416 were synthesized. The cytotoxic effects of the analogs were evaluated against PC-3 and MDA-MB-231 cancer cell lines, as well as their abilities to inhibit tubulin polymerization. Results are compared to those of compound 1, our lead compound previously reported. (c) 2006 Elsevier Ltd. All rights reserved.