1-tert-Butylamino-3-(2,5-dimethyl-phenoxy)-propan-2-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-tert-Butylamino-3-(2,5-dimethyl-phenoxy)-propan-2-ol
• 英文别名: 1-(Tert-butylamino)-3-(2,5-dimethylphenoxy)propan-2-ol
• 化学式: C₁₅H₂₅NO₂
• mdl: MFCD02696980
• 分子量: 251.369
• InChiKey: ZTACUJBXYKWWOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  41.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-[(2,5-二甲基苯氧基)甲基]环氧乙烷 、 叔丁胺 生成 1-tert-Butylamino-3-(2,5-dimethyl-phenoxy)-propan-2-ol
  参考文献：
  名称：

  DE1236523

  摘要：

  公开号：

文献信息

• COMPOSITIONS AND METHODS FOR THE TREATMENT OF SOMATOSENSORY DISORDERS
  申请人：Diatchenko Luda

  公开号：US20110245208A1

  公开（公告）日：2011-10-06

  A method of combating a somatosensory disorder in a subject, comprising administering to the subject an effective amount of a composition comprising bupranolol and/or pharmaceutically acceptable derivative(s) thereof. Compositions useful for such administration are described, including salts, esters, solvates, etc. of tert-butyl[3-(2-chloro-5-methylphenoxy)-2-hydroxypropyl]amine, in which such salt, ester, solvate, etc. compound is in enantiomeric excess or homoenantiomeric in the R isomer thereof, or is formulated with racemic mixtures of the R and S stereoisomers of the salts, esters, solvates, etc. of tert-butyl[3-(2-chloro-5-methylphenoxy)-2-hydroxypropyl]amine. Combination therapy compositions of opioid receptor agonists and such compounds are also described. A method is disclosed of referential genotypic screening of candidate subjects in connection with therapeutic intervention using the compositions of the disclosure to combat the somatosensory disorder.
• US8716349B2
  申请人：——

  公开号：US8716349B2

  公开（公告）日：2014-05-06
• US8716350B2
  申请人：——

  公开号：US8716350B2

  公开（公告）日：2014-05-06
• DE1236523
  申请人：——

  公开号：——

  公开（公告）日：——