Tin(II) trifluoromethanesulfonate, 97%

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: Tin(II) trifluoromethanesulfonate, 97%
• 英文别名: bis(trifluoromethylsulfonyloxy)tin
• 化学式: C2F6O6S2Sn
• 分子量: 416.9
• InChiKey: RBGLVWCAGPITBS-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -0.28
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  131
• 氢给体数：
  0
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  (+)-(4S)-3-(Chloroacetyl)-4-(1-methylethyl)-2-oxazolidinone 、 Tin(II) trifluoromethanesulfonate, 97% 生成 (4S)-3-[(2S,3R)-2-chloro-3-hydroxyoctanoyl]-4-propan-2-yl-1,3-oxazolidin-2-one
  参考文献：
  名称：

  J. AMER. CHEM. SOC., 108,(1986) N 15, 4595-4602

  摘要：

  DOI：

文献信息

• Processes for preparing carbapenem derivatives
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US05306816A1

  公开（公告）日：1994-04-26

  The invention relates to carbapenem derivatives useful as antimicrobial agents, more particularly to intermediate compounds for the preparations thereof of the formula ##STR1##

  该发明涉及一种作为抗微生物剂有用的碳青霉烯衍生物，更具体地涉及制备该类化合物的中间体，其化学式为##STR1##
• DIAMINOPROPANE DERIVED MACROCYCLES AS INHIBITORS OF BETA AMYLOID PRODUCTION
  申请人：Marcin Lawrence R.

  公开号：US20080194535A1

  公开（公告）日：2008-08-14

  There is provided a series of macrocyclic diaminopropanes of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , m, n, W, X, Y, Z and L as defined herein, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein (APP) by β-secretase and, more specifically, inhibit the production of Aβ-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to β-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.

  本发明提供了一系列宏环二胺丙烷化合物，其化学式为(I)或其立体异构体；或其药学上可接受的盐，其中R1、R2、R3、m、n、W、X、Y、Z和L的定义如本文所述，以及它们的制药组合物和使用方法。这些新型化合物能够抑制β-分泌酶对淀粉样前体蛋白(APP)的加工，更具体地说，能够抑制Aβ肽的产生。本公开的内容涉及用于治疗与β-淀粉样蛋白产生相关的神经疾病，例如阿尔茨海默病和其他受抗淀粉样蛋白活性影响的疾病的化合物。
• Intermediates of 2-Substituted Carbapenem Derivatives and Process for Production Thereof
  申请人：Sasaki Toshiro

  公开号：US20080076917A1

  公开（公告）日：2008-03-27

  The present invention relates to compounds represented by formula (1) and a process for producing the same. The use of these compounds can realize the production of carbapenem derivatives having potent antimicrobial activity and a wide antimicrobial spectrum in a safe and cost-effective manner.

  本发明涉及由公式（1）表示的化合物以及其制备方法。使用这些化合物可以以安全且具有成本效益的方式实现具有强大的抗微生物活性和广泛的抗微生物谱的碳青霉烯衍生物的生产。
• Quinazoline derivatives useful in cancer treatment
  申请人：Mallams K. Alan

  公开号：US20070015774A1

  公开（公告）日：2007-01-18

  The present invention provides compounds of Formula I (wherein R 1 , R 2 , R 3 , L, and X are as defined herein). or a pharmaceutically acceptable salt, solvate or ester thereof. The present invention also provides compositions comprising these compounds that are useful for treating cellular proliferative diseases, disorders associated with activity of mutants of p53, or in causing apoptosis of cancer cells.

  本发明提供了I式化合物（其中R1、R2、R3、L和X的定义如本文所述）或其药学上可接受的盐、溶剂或酯。本发明还提供了包含这些化合物的组合物，用于治疗细胞增殖性疾病、与p53突变体活性相关的疾病或导致癌细胞凋亡的疾病。
• Intermediates of 2-substituted carbapenem derivatives and process for production thereof
  申请人：Sasaki Toshiro

  公开号：US20080167475A1

  公开（公告）日：2008-07-10

  The present invention relates to compounds represented by formula (1) and a process for producing the same. The use of these compounds can realize the production of carbapenem derivatives having potent antimicrobial activity and a wide antimicrobial spectrum in a safe and cost-effective manner.

  本发明涉及由式（1）表示的化合物以及其生产过程。这些化合物的使用可以以安全且经济的方式实现具有强大抗微生物活性和广谱抗微生物的碳青霉烯衍生物的生产。

表征谱图