FMOC-(3S)-3-1-羧甲基-2-戊内酰胺 | 215190-25-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: FMOC-(3S)-3-1-羧甲基-2-戊内酰胺
• 英文名称: [(S)-3-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-oxo-piperidin-1-yl]-acetic acid
• 英文别名: (S)-2-(3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-oxopiperidin-1-yl)acetic acid；2-[(3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-2-oxopiperidin-1-yl]acetic acid
• CAS: 215190-25-3
• 化学式: C₂₂H₂₂N₂O₅
• 分子量: 394.427
• InChiKey: WGBORFZFCVWACO-IBGZPJMESA-N

物化性质

• 沸点：
  686.5±55.0 °C(Predicted)
• 密度：
  1.38±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  95.9
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  C₃₁H₃₁N₃O₂ 、 FMOC-(3S)-3-1-羧甲基-2-戊内酰胺 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以81%的产率得到
  参考文献：
  名称：

  Design, synthesis, and evaluation of peptidomimetics containing Freidinger lactams as STAT3 inhibitors

  摘要：

  The STAT3 oncogene is a promising molecular target for the design of a new class of anticancer drugs. In this letter, we describe the design, synthesis, and evaluation of peptidomimetics containing Freidinger lactams as novel STAT3 inhibitors. Compound 3 binds to STAT3 with a K-i value of 190 nM and is a promising lead compound for further design and optimization. (C) 2009 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2009.01.091

文献信息

• Novel Hydrazino-Carbonyl-Amino- Methylated Polystyrene (HCAM) Resin Methodology for the Synthesis of P₁-Aldehyde Protease Inhibitor Candidates
  作者：Daniel V. Siev、J. Edward Semple

  DOI：10.1021/ol991161e

  日期：2000.1.1

  [GRAPHICS]A new strategy for the synthesis of peptidyl and peptidomimetic P-1-aldehydes 3 on HCAM solid support is described. The appropriate C-terminal aldehyde precursors were prepared and anchored to a resin support via a semicarbazone linkage (HCAM resin). After synthetic elaboration, acidic hydrolysis efficiently delivered C-terminal target aldehydes 3a-h in good overall yields and in excellent purity.
• INHIBITORS OF PEPTIDE BINDING TO MHC CLASS II PROTEINS
  申请人：ZENECA LIMITED

  公开号：EP0946589A1

  公开（公告）日：1999-10-06
• Methods for synthesis of encoded libraries
  申请人：Morgan Barry

  公开号：US20070042401A1

  公开（公告）日：2007-02-22

  The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
• Methods for identifying compounds of interest using encoded libraries
  申请人：Morgan Barry

  公开号：US20070224607A1

  公开（公告）日：2007-09-27

  The present invention provides a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag.
• METHODS FOR SYNTHESIS OF ENCODED LIBRARIES
  申请人：MORGAN Barry

  公开号：US20110136697A1

  公开（公告）日：2011-06-09

  The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.