EDA

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: EDA
• 英文别名: (3S)-4-formyl-3-(2-oxoethyl)hex-4-enoic acid
• 化学式: C₉H₁₂O₄
• 分子量: 184.192
• InChiKey: DBMWDRVDXUPGBP-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  71.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  EDA 在 selenium(IV) oxide 、 双氧水 作用下， 以 四氢呋喃 为溶剂， 以67 %的产率得到3-(1-Oxobut-2-en-2-yl)pentanedioic acid
  参考文献：
  名称：

  橄榄油Secoiridoids的氧化形式：半合成，鉴定和与质量参数的相关性。

  摘要：

  类环烯醚萜是橄榄油极性成分的主要化学类别，具有显着的生物学特性。与其他成分相比，它们富含不同的化学形式和相对较高的浓度，同时由于其化学基序而易于氧化。近年来，据报道，作为橄榄油的天然成分或在其生产和储存的各个阶段逐渐形成的成分，secioridoids 的氧化衍生物。最近从橄榄油中分离出单氧化形式的油橄榄酚和油酸甘油酯，分别命名为相应的酸，并对其结构进行了明确的表征。文献中也偶尔提及其他氧化形式的榄香酸或更复杂的类环烯醚萜，例如橄榄苦苷和川芎甙苷元。没有提供进一步的信息，因为它们没有以纯粹的形式被分离出来以便准确识别。大多数时候，它们通常被称为母体化合物的氧化形式，通常根据质谱数据进行识别。在目前的研究中，描述了主要的氧化橄榄油secoiridoids的半合成，即油橄榄酸、油酸、EDA酸、烯醇酸的羧基形式、川芎甙苷苷元的羧基形式和橄榄苦苷苷元的羧基形式。相应的醛衍生物，使用 SeO2/H2O2

  DOI：

  10.1055/a-1806-7815

文献信息

• MALODOR COUNTERACTING COMPOSITIONS
  申请人：International Flavors & Fragrances Inc.

  公开号：EP3101171A1

  公开（公告）日：2016-12-07

  A malodor counteracting composition contains a malodor counteractant that is capable of neutralizing a malodor and a stabilizer that is capable of decreasing or preventing self-polymerization of the malodor counteractant. The malodor counteractant has a backbone and one or more reactive end groups that are covalently attached to the backbone, the backbone has a molecular weight of 100 to 50,000 Daltons, and the one or more reactive end groups each have an α,β-unsaturated carbonyl group. Also disclosed are consumer, industrial or textile products containing the malodor counteracting composition and methods of neutralizing malodor using the composition.

  一种恶臭抑制组合物含有一种能够中和恶臭的恶臭抑制剂和一种能够减少或防止恶臭抑制剂自聚合的稳定剂。恶臭抑制剂具有骨架和一个或多个共价连接到骨架上的活性末端基团，骨架的分子量为 100 至 50,000 道尔顿，一个或多个活性末端基团各自具有一个 α、β-不饱和羰基。此外，还公开了含有恶臭抑制组合物的消费品、工业品或纺织品，以及使用该组合物中和恶臭的方法。
• Malodor counteracting compositions
  申请人：Sasaki Takashi

  公开号：US10226544B2

  公开（公告）日：2019-03-12

  A malodor counteracting composition contains a malodor counteractant that is capable of neutralizing a malodor and a stabilizer that is capable of decreasing or preventing self-polymerization of the malodor counteractant. The malodor counteractant has a backbone and one or more reactive end groups that are covalently attached to the backbone, the backbone has a molecular weight of 100 to 50,000 Daltons, and the one or more reactive end groups each have an α,β-unsaturated carbonyl group. Also disclosed are consumer, industrial or textile products containing the malodor counteracting composition and methods of neutralizing malodor using the composition.

  一种恶臭抑制组合物含有一种能够中和恶臭的恶臭抑制剂和一种能够减少或防止恶臭抑制剂自聚合的稳定剂。恶臭抑制剂具有骨架和一个或多个共价连接到骨架上的活性末端基团，骨架的分子量为 100 至 50,000 道尔顿，一个或多个活性末端基团各自具有一个 α、β-不饱和羰基。此外，还公开了含有恶臭抑制组合物的消费品、工业品或纺织品，以及使用该组合物中和恶臭的方法。
• Treatment and prevention of joint disorders
  申请人：Summit Innovation Labs, LLC

  公开号：US11007171B2

  公开（公告）日：2021-05-18

  The invention encompasses compositions and methods for effectively treating and/or preventing the development and/or progression of osteoarthritis and rheumatoid arthritis and for promoting overall joint health. This is accomplished by totally addressing the key multiple biochemical processes and mechanisms that lead to such disorders. The invention includes compositions comprising a combination of natural agents that safely and effectively suppress, regulate or interfere with the various biochemical processes and mechanisms that increase the risk for or lead to the development and/or progression of OA and RA. The present compositions are holistically formulated to be effective in preventing/arresting loss of and/or damage to the articular cartilage (AC) by suppressing (a) extracellular matrix (ECM) degradation, (b) chondrocyte apoptosis, and (c) inflammation of synovium through modulation of mechanisms that involve transcription factors, growth factors, kinases, antiapoptotic/apoptotic factors and deacetylases. The active agents used herein are natural materials, in particular phytonutrients (or phytochemicals), minerals and/or vitamins.

  本发明包括有效治疗和/或预防骨关节炎和类风湿性关节炎的发展和/或恶化以及促进整体关节健康的组合物和方法。这是通过彻底解决导致此类疾病的多种关键生化过程和机制来实现的。本发明包括由天然制剂组合而成的组合物，这些天然制剂能安全有效地抑制、调节或干扰各种生化过程和机制，而这些生化过程和机制会增加患 OA 和 RA 的风险，或导致 OA 和 RA 的发展和/或恶化。本组合物采用整体配方，通过调节涉及转录因子、生长因子、激酶、抗凋亡/凋亡因子和去乙酰化酶的机制，抑制(a)细胞外基质（ECM）降解、(b)软骨细胞凋亡和(c)滑膜炎症，从而有效预防/阻止关节软骨（AC）的损失和/或损伤。这里使用的活性剂是天然材料，特别是植物营养素（或植物化学物质）、矿物质和/或维生素。
• Treatment and Prevention of Joint Disorders
  申请人：Mehansho Haile

  公开号：US20190015384A1

  公开（公告）日：2019-01-17

  The invention encompasses compositions and methods for effectively treating and/or preventing the development and/or progression of osteoarthritis and rheumatoid arthritis and for promoting overall joint health. This is accomplished by totally addressing the key multiple biochemical processes and mechanisms that lead to such disorders. The invention includes compositions comprising a combination of natural agents that safely and effectively suppress, regulate or interfere with the various biochemical processes and mechanisms that increase the risk for or lead to the development and/or progression of OA and RA. The present compositions are holistically formulated to be effective in preventing/arresting loss of and/or damage to the articular cartilage (AC) by suppressing (a) extracellular matrix (ECM) degradation, (b) chondrocyte apoptosis, and (c) inflammation of synovium through modulation of mechanisms that involve transcription factors, growth factors, kinases, antiapoptotic/apoptotic factors and deacetylases. The active agents used herein are natural materials, in particular phytonutrients (or phytochemicals), minerals and/or vitamins.