N-(6-fluoropyridin-3-yl)-1-(4-(3-isopropyl-1H-pyrazol-5-ylamino)-7,7-dimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl)pyrrolidine-2-carboxamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(6-fluoropyridin-3-yl)-1-(4-(3-isopropyl-1H-pyrazol-5-ylamino)-7,7-dimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl)pyrrolidine-2-carboxamide
• 英文别名: 1-[7,7-dimethyl-4-[(5-propan-2-yl-1H-pyrazol-3-yl)amino]-5,6-dihydrocyclopenta[d]pyrimidin-2-yl]-N-(6-fluoropyridin-3-yl)pyrrolidine-2-carboxamide
• 化学式: C₂₅H₃₁FN₈O
• 分子量: 478.6
• InChiKey: BTQCRSBEEFFWAC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2-氟-5-氨基吡啶 、 异丙基氯化镁 、 methyl 1-(4-(3-isopropyl-1H-pyrazol-5-ylamino)-7,7-dimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl)pyrrolidine-2-carboxylate 在 氯化铵 、 乙酸乙酯 、 Brine 、 Sodium sulfate-III 、 crude product 作用下， 以 四氢呋喃 为溶剂， 反应 2.33h， 以to afford N-(6-fluoropyridin-3-yl)-1-(4-(3-isopropyl-1H-pyrazol-5-ylamino)-7,7-dimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl)pyrrolidine-2-carboxamide (40 mg)的产率得到N-(6-fluoropyridin-3-yl)-1-(4-(3-isopropyl-1H-pyrazol-5-ylamino)-7,7-dimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl)pyrrolidine-2-carboxamide
  参考文献：
  名称：

  FUSED PYRIMIDINE COMPOUNDS AND USE THEREOF

  摘要：

  提供了作为激酶抑制剂的融合嘧啶化合物，例如多激酶抑制剂。提供了作为IGF-IR抑制剂的融合嘧啶化合物。还提供了抑制Trk受体（例如Trk A，Trk B和Trk C）的融合嘧啶化合物。这些化合物可以用于治疗癌症的方法。还提供了含有融合嘧啶化合物和药用载体的制药组合物，以及包含融合嘧啶化合物或其盐和使用说明的试剂盒，例如用于治疗癌症的方法。

  公开号：

  US20160068513A1

文献信息

• CYCLOPROPYL MODULATORS OF P2Y12 RECEPTOR
  申请人：Auspex Pharmaceuticals, Inc.

  公开号：US20140286943A1

  公开（公告）日：2014-09-25

  The present invention relates to new cyclopropyl modulators of P2Y12 receptor activity, pharmaceutical compositions thereof, and methods of use thereof.

  本发明涉及P2Y12受体活性的新的环丙基调节剂，其制药组合物以及使用方法。
• FUSED CYCLOALKYL-PYRIMIDINE COMPOUNDS AND USES THEREOF
  申请人：Medivation Technologies, Inc.

  公开号：US20170137410A1

  公开（公告）日：2017-05-18

  Fused cycloalkyl-pyrimidine compounds that are kinase inhibitors, such as multi-kinase inhibitors, are provided. The compounds may be used in a method of treating cancer. Pharmaceutical compositions containing a fused cycloalkyl-pyrimidine compound and a pharmaceutically acceptable carrier are also provided, as are kits containing a fused cycloalkyl-pyrimidine compound or salt thereof and instructions for use, e.g., in a method of treating cancer.
• US9422267B2
  申请人：——

  公开号：US9422267B2

  公开（公告）日：2016-08-23
• US9499519B2
  申请人：——

  公开号：US9499519B2

  公开（公告）日：2016-11-22
• [EN] FUSED PYRIMIDINE COMPOUNDS AND USE THEREOF<br/>[FR] COMPOSÉS PYRIMIDINE FUSIONNÉS ET LEUR UTILISATION
  申请人：MEDIVATION TECHNOLOGIES INC

  公开号：WO2014105958A2

  公开（公告）日：2014-07-03

  Fused pyrimidine compounds as kinase inhibitors, such as multi-kinase inhibitors, are provided. Fused pyrimidine compounds as IGF-IR inhibitors are provided. Fused pyrimidine compounds that are inhibitors of Trk receptors (e.g., Trk A, Trk B and Trk C) are provided also. The compounds may be used in a method of treating cancer. Pharmaceutical compositions containing a fused pyrimidine compound and a pharmaceutically acceptable carrier are also provided, as are kits containing a fused pyrimidine compound or salt thereof and instructions for use, e.g., in a method of treating cancer.