2-(4'-Amino-3'-iodophenyl)-6-methylbenzothiazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 2-(4'-Amino-3'-iodophenyl)-6-methylbenzothiazole
• 英文别名: 2-iodo-4-(6-methyl-1,3-benzothiazol-2-yl)aniline
• 化学式: C₁₄H₁₁IN₂S
• 分子量: 366.22
• InChiKey: HHKCYVZNMDYRMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  67.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-(4-氨基苯基)-6-甲基苯并噻唑 、 一氯化碘 在 Crude product 、 silica gel 作用下， 以 溶剂黄146 为溶剂， 以to give brown small crystals (0.61 g, 66.7%), m.p. 176.2-177.9° C.的产率得到2-(4'-Amino-3'-iodophenyl)-6-methylbenzothiazole
  参考文献：
  名称：

  2-arylbenzazole compounds

  摘要：

  本文披露了一种具有3'-取代基和4'-NR.sup.2 R.sup.6 取代基的2-苯基苯并咪唑化合物，其中R.sup.5和R.sup.6分别为氢或烷基，或者$'-NR.sup.5 R.sup.6 取代基为N-酰基（或N-苯甲酰基）。还披露了以4'-N磺酰酸盐形式存在的2-苯基苯并咪唑化合物。这些化合物在肿瘤细胞方面表现出显著的选择性细胞毒性活性，并提供了潜在有用的化疗药物，用于选择性治疗一系列癌症。

  公开号：

  US06034246A1

文献信息

• AMYLOID IMAGING AS A SURROGATE MARKER FOR EFFICACY OF ANTI-AMYLOID THERAPIES
  申请人：KLUNK William E.

  公开号：US20120177572A1

  公开（公告）日：2012-07-12

  The present method for determining the efficacy of therapy in the treatment of amyloidosis involves administering to a patient in need thereof a compound of formula (I) or formula (II) or structures 1-45 and imaging the patient. After said imaging, at least one anti-amyloid agent is administered to said patient. Then, an effective amount of a compound of formula (I) or formula (II) or structures 1-45 is administered to the patient and the patient is imaged again. Finally, baseline levels of amyloid deposition in the patient before treatment with the anti-amyloid agent are compared with levels of amyloid deposition in the patient following treatment with the anti-amyloid agent.

  目前评估淀粉样变性疗法疗效的方法包括向需要治疗的患者施用式(I)或式(II)或结构1-45的化合物，并对患者进行成像。成像后，至少给该患者施用一种抗淀粉样物质。然后，向患者施用有效量的式(I)或式(II)或结构1-45的化合物，并再次对患者进行成像。最后，将抗淀粉样物质治疗前患者的淀粉样沉积基线水平与抗淀粉样物质治疗后患者的淀粉样沉积水平进行比较。
• THIOFLAVIN DERIVATIVES FOR USE IN ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION
  申请人：KLUNK William E.

  公开号：US20110257407A1

  公开（公告）日：2011-10-20

  This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimer's disease, familial Alzheimer's disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele.

  本发明涉及一种新型噻吩黄素衍生物，使用该衍生物的方法，例如在患有神经元斑块的患者中进行体内成像，包含该噻吩黄素衍生物的制药组合物和合成该化合物的方法。该化合物在诊断和治疗患有神经元斑块积累的疾病患者中具有特殊用途。这些疾病状态或疾病包括但不限于阿尔茨海默病、家族性阿尔茨海默病、唐氏综合症和载脂蛋白E4等位基因纯合子。
• THIOFLAVIN DERIVATIVES FOR USE IN ANTEMORTEM DIAGNOSIS OF ALZHEIMER`S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION
  申请人：Klunk William E.

  公开号：US20130236394A1

  公开（公告）日：2013-09-12

  This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimer's disease, familial Alzheimer's disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele.

  本发明涉及一种新的噻吩素衍生物，使用该衍生物的方法，例如在患有神经纤维结节的患者的体内成像，包含该噻吩素衍生物的制药组合物以及合成该化合物的方法。该化合物在诊断和治疗患有神经纤维结节积累的疾病的患者中具有特殊用途。这些疾病状态或疾病包括但不限于阿尔茨海默病，家族性阿尔茨海默病，唐氏综合症和载脂蛋白E4等位基因的纯合子。
• 2-ARYLBENZAZOLE COMPOUNDS
  申请人：Cancer Research Ventures Limited

  公开号：EP0812319B1

  公开（公告）日：2002-07-10
• USE OF THIOFLAVIN RADIOLABELED DERIVATIVES IN AMYLOID IMAGING FOR ASSESSING ANTI-AMYLOID THERAPIES
  申请人：University of Pittsburgh - Of the Commonwealth System of Higher Education

  公开号：EP1771208B1

  公开（公告）日：2013-06-19