(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[12-[(2S)-2-[[(2S)-5-amino-1-[[(2S,3S)-1-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-12-oxododecanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-3-phenylpropanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[12-[(2S)-2-[[(2S)-5-amino-1-[[(2S,3S)-1-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-12-oxododecanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-3-phenylpropanoic acid
• 化学式: C₇₅H₁₁₄N₁₄O₂₀
• 分子量: 1531.81
• InChiKey: RSCRLAMDDVNEQN-JVFWASJLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  109
• 可旋转键数：
  50
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  549
• 氢给体数：
  18
• 氢受体数：
  20

反应信息

• 作为产物：
  描述：

  dodecanedioic acid bis(2,5-dioxopyrrolidin-1-yl) ester 、 (S)-2-((S)-2-{(S)-2-[(2S,3R)-2-((S)-2-Amino-3-hydroxy-propionylamino)-3-hydroxy-butyrylamino]-4-methyl-pentanoylamino}-3-carbamoyl-propionylamino)-3-phenyl-propionic acid 、 HNPro-Gln-Ile-Thr-Leu-Trp-OH 在 N,N-二异丙基乙胺 作用下， 生成 (2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[12-[(2S)-2-[[(2S)-5-amino-1-[[(2S,3S)-1-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-12-oxododecanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-3-phenylpropanoic acid
  参考文献：
  名称：

  Targeting the Dimerization Interface of HIV-1 Protease:  Inhibition with Cross-Linked Interfacial Peptides

  摘要：

  Agents have been designed and synthesized which target the dimerization interface of HIV-1 protease. These agents, which contain cross-linked peptides from the N- and C-termini of the protease, both inhibit HIV-1 protease activity and decrease the amount of protease dimer in solution as measured by size exclusion chromatography, protein crosslinking, and protease fluorescence studies. Additionally we have shown that active site-targeted agents inhibit HIV-1 protease activity but have little effect on protease dimerization. These data support the claim that inhibition with the crosslinked agents is based on a decrease in the amount of protease homodimer in solution which in turn is responsible for a decrease in the activity of the protease.

  DOI：

  10.1021/ja962496j

文献信息

• Targeting the Dimerization Interface of HIV-1 Protease:  Inhibition with Cross-Linked Interfacial Peptides
  作者：Reena Zutshi、Jeff Franciskovich、Michael Shultz、Barbara Schweitzer、Patricia Bishop、Matt Wilson、Jean Chmielewski

  DOI：10.1021/ja962496j

  日期：1997.5.1

  Agents have been designed and synthesized which target the dimerization interface of HIV-1 protease. These agents, which contain cross-linked peptides from the N- and C-termini of the protease, both inhibit HIV-1 protease activity and decrease the amount of protease dimer in solution as measured by size exclusion chromatography, protein crosslinking, and protease fluorescence studies. Additionally we have shown that active site-targeted agents inhibit HIV-1 protease activity but have little effect on protease dimerization. These data support the claim that inhibition with the crosslinked agents is based on a decrease in the amount of protease homodimer in solution which in turn is responsible for a decrease in the activity of the protease.