β-(N-Isopropylamino)alanin | 65301-83-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: β-(N-Isopropylamino)alanin
• 英文别名: 2-Amino-3-(propan-2-ylamino)propanoic acid
• CAS: 65301-83-9
• 化学式: C₆H₁₄N₂O₂
• 分子量: 146.189
• InChiKey: GVAXHCRMYKGAGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  75.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  β-(N-Isopropylamino)-N(α)acetylalanin 在 盐酸 作用下， 生成 β-(N-Isopropylamino)alanin
  参考文献：
  名称：

  一些β-氨基丙氨酸衍生物的合成，鉴定和性质

  摘要：

  从乙酰基脱氢丙氨酸合成了许多新的β-（N-烷基氨基）丙氨酸。使用角蛋白作为含胱氨酸的蛋白质，已经表明，在用一系列胺处理时，取决于所用胺的结构，在蛋白质中形成不同量的β-（N烷基氨基）丙氨酸残基。

  DOI：

  10.1016/0040-4020(77)80175-0

文献信息

• [EN] BETA-HAIRPIN PEPTIDOMIMETICS<br/>[FR] PEPTIDOMIMÉTIQUES EN ÉPINGLE À CHEVEUX BÊTA
  申请人：POLYPHOR AG

  公开号：WO2016150576A1

  公开（公告）日：2016-09-29

  Beta-hairpin peptidomimetics of the general formula (I), and pharmaceutically acceptable salts thereof, with P, T, Q., and optionally L being elements as defined in the description and the claims, have Gram-negative antimicrobial activity to e.g. inhibit the growth or to kill microorganisms such as Klebsiellapneumoniae and/or Acinetobacter baumannii and/or Escherichia coli and/or Pseudomonas aeruginosa. They ca n be used as medicaments to treat or prevent infections or as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.

  Beta-发夹仿生肽的一般公式（I），及其药学上可接受的盐，其中P、T、Q.，以及可选的L作为描述和权利要求中定义的元素，具有抗革兰氏阴性微生物活性，例如抑制生长或杀灭肺炎克雷伯菌、包括鲍曼不动杆菌、大肠杆菌和铜绿假单胞菌等微生物。它们可用作药物治疗或预防感染，或用作食品、化妆品、药物或其他含营养物质的材料的消毒剂。这些仿生肽可以通过基于混合固相和溶液相合成策略的过程制造。
• AMINO-ETHYL-AMINO-ARYL (AEAA) COMPOUNDS AND THEIR USE
  申请人：Raynham Tony Michael

  公开号：US20090247519A1

  公开（公告）日：2009-10-01

  The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain amino-ethyl-amino-aryl (AEAA) compounds which, inter alia, inhibit protein kinase D (PKD) (e.g., PKD1, PKD2, PKD3). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit PKD, and in the treatment of diseases and conditions that are mediated by PKD, that are ameliorated by the inhibition of PKD, etc., including proliferative conditions such as cancer, etc.

  本发明一般涉及治疗化合物领域，更具体地涉及某些氨基乙基氨基芳基（AEAA）化合物，该化合物在抑制蛋白激酶D（PKD）（例如，PKD1、PKD2、PKD3）方面起作用。本发明还涉及包含这些化合物的药物组合物，以及在体外和体内使用这些化合物和组合物来抑制PKD，并用于治疗由PKD介导的疾病和症状，通过抑制PKD而改善的疾病和症状等，包括增殖性疾病如癌症等。
• BETA-HAIRPIN PEPTIDOMIMETICS
  申请人：POLYPHOR AG

  公开号：US20160052971A1

  公开（公告）日：2016-02-25

  Beta-hairpin peptidomimetics of the general formula (I), cyclo[P 1 -p 2 -p 3 -p 4 -p 5 -p 6 -p 7 -p 8 p 9 -p 10 -p 11 -p 12 -T 1 -T 2 ], and pharmaceutically acceptable salts thereof, with P 1 to P 12 , T 1 and T 2 being elements as defined in the description and the claims, have Gram-negative antimicrobial activity to e.g. inhibit the growth or to kill microorganisms such as Klebsiella pneumoniae and/or Acinetobacter baumannii and/or Escherichia coli . They can be used as medicaments to treat or prevent infections or as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.

  一般式（I）的β-发夹肽类似物，其化学式为cyclo[P1-p2-p3-p4-p5-p6-p7-p8p9-p10-p11-p12-T1-T2]及其药用盐，其中P1至P12、T1和T2为描述和索赔中定义的元素，具有抗革兰氏阴性菌活性，例如抑制生长或杀灭肺炎克雷伯氏菌、鲍曼不动杆菌和/或大肠杆菌等微生物。它们可用作药物治疗或预防感染，或用作食品、化妆品、药物或其他营养物质的消毒剂。这些肽类似物可以通过基于混合固相和溶液相合成策略的工艺制造。
• Beta-hairpin peptidomimetics
  申请人：POLYPHOR AG

  公开号：US10259847B2

  公开（公告）日：2019-04-16

  Beta-hairpin peptidomimetics of the general formula (I), cyclo[P1-P2-P3-P4-P5-P6-P7-P8-P9-P10-P11-P12-T1-T2], and pharmaceutically acceptable salts thereof, with P1 to P12, T1 and T2 being elements as defined in the description and the claims, have Gram-negative antimicrobial activity to e.g. inhibit the growth or to kill microorganisms such as Klebsiella pneumoniae and/or Acinetobacter baumannii and/or Escherichia coli. They can be used as medicaments to treat or prevent infections or as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.

  通式(I)、环[P1-P2-P3-P4-P5-P6-P7-P8-P9-P10-P11-P12-T1-T2]的β-发夹肽拟物化物及其药学上可接受的盐，其中 P1 至 P12、T1 和 T2 是如说明书和权利要求书中所定义的元素，具有革兰氏阴性抗菌活性，例如抑制肺炎克雷伯菌和/或鲍曼尼不动杆菌和/或大肠埃希菌等微生物的生长或杀灭它们。g. 抑制肺炎克雷伯氏菌和/或鲍曼不动杆菌和/或大肠埃希氏菌等微生物的生长或将其杀死。它们可用作治疗或预防感染的药物，或用作食品、化妆品、药品或其他含营养物质的消毒剂。这些拟肽物可通过基于固相和溶相混合合成策略的工艺制造。
• β-hairpin peptidomimetics
  申请人：POLYPHOR AG

  公开号：US10654897B2

  公开（公告）日：2020-05-19

  Beta-hairpin peptidomimetics of the general formula (I), cyclo[P1-P2-P3-P4-P5-P6-P7-P8-P9-P10-P11-P12-T1-T2] and pharmaceutically acceptable salts thereof, with P1 to P12, T1 and T2 being elements as defined in the description and the claims, have Gramnegative antimicrobial activity to e.g. inhibit the growth or to kill microorganisms such as Klebsiella pneumoniae and/or Acinetobacter baumannii and/or Escherichia coli. They can be used as medicaments to treat or prevent infections or as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.

  通式(I)、环[P1-P2-P3-P4-P5-P6-P7-P8-P9-P10-P11-P12-T1-T2]的β-发夹肽拟物化物及其药学上可接受的盐，其中 P1 至 P12、T1 和 T2 是如说明书和权利要求书中所定义的元素，具有革兰氏阴性抗菌活性，例如抑制肺炎克雷伯菌和/或鲍曼尼不动杆菌和/或大肠埃希菌等微生物的生长或杀灭这些微生物。g. 抑制肺炎克雷伯氏菌和/或鲍曼不动杆菌和/或大肠埃希氏菌等微生物的生长或将其杀死。它们可用作治疗或预防感染的药物，或用作食品、化妆品、药品或其他含营养物质的消毒剂。这些拟肽物可通过基于固相和溶相混合合成策略的工艺制造。