4-(3-tert-butylamino-2-hydroxypropoxy)-2-methyl indole | 62928-55-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 4-(3-tert-butylamino-2-hydroxypropoxy)-2-methyl indole
• 英文别名: Sdz 21-009；4-(2-Hydroxy-3-tert-butylaminopropoxy)-2-methylindole；1-(tert-butylamino)-3-[(2-methyl-1H-indol-4-yl)oxy]propan-2-ol
• CAS: 62928-55-6
• 化学式: C₁₆H₂₄N₂O₂
• 分子量: 276.379
• InChiKey: BGQHPLYSXBZMQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  57.3
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  苯甲酸 、 4-(3-tert-butylamino-2-hydroxypropoxy)-2-methyl indole 、 苯甲酸酐 生成 吲苯脂心安
  参考文献：
  名称：

  TROXLER, F.;SEEMANN, F.

  摘要：

  DOI：

文献信息

• Use of 4-(2-benzoyloxy-3-tert-butylaminopropoxy)-2-methyl-indole for
  申请人：Sandoz Ltd.

  公开号：US04434176A1

  公开（公告）日：1984-02-28

  This invention provides compounds of formula I, ##STR1## wherein R.sub.1 is phenyl; phenyl monosubstituted with fluorine; phenyl mono- or disubstituted with chlorine; phenyl mono-, di- or trisubstituted with methyl or methoxy, secondary 1-phenoxyalkyl, the secondary alkyl residue of which is of 3 to 5 carbon atoms and in which the phenyl residue is unsubstituted or monosubstituted with chlorine, and either R.sub.2 is hydrogen, and R.sub.3 is methyl, or R.sub.2 is methyl and R.sub.3 is hydrogen or methyl, which are useful, for example, for treating coronary conditions.

  本发明提供了公式I的化合物，其中R1为苯基；单取代氟的苯基；单或双取代氯的苯基；单、双或三取代甲基或甲氧基，次级1-苯氧基烷基，其次级烷基残基为3至5个碳原子，其中苯基残基未取代或单取代氯，且R2为氢，R3为甲基，或R2为甲基，R3为氢或甲基。这些化合物可用于治疗冠状动脉疾病等病症。
• 4-(2-Benzoyloxy-3-tert.-butylaminopropoxy-2-methyl indole
  申请人：Sandoz Ltd.

  公开号：US04340541A1

  公开（公告）日：1982-07-20

  This invention provides compounds of formula I, ##STR1## wherein R.sub.1 is phenyl; phenyl monosubstituted with fluorine; phenyl mono- or disubstituted with chlorine; phenyl mono-, di- or trisubstituted with methyl or methoxy, secondary 1-phenoxyalkyl, the secondary alkyl residue of which is of 3 to 5 carbon atoms and in which the phenyl residue is unsubstituted or monosubstituted with chlorine, and either R.sub.2 is hydrogen, and R.sub.3 is methyl, or R.sub.2 is methyl and R.sub.3 is hydrogen or methyl, which are useful, for example, for treating coronary conditions.

  本发明提供了式I的化合物，其中R.sub.1是苯基；单取代氟的苯基；单取代或双取代氯的苯基；单取代、双取代或三取代甲基或甲氧基的苯基，次生1-苯氧基烷基，其中次生烷基残基为3至5个碳原子，并且苯基残基未取代或单取代氯，且R.sub.2为氢，R.sub.3为甲基，或者R.sub.2为甲基，R.sub.3为氢或甲基。这些化合物可用于治疗冠状动脉疾病等。
• Compositions of a cyclooxygenase-2 selective inhibitor and a serotonin-modulating agent for the treatment of central nervous system damage
  申请人：Stephenson T. Diane

  公开号：US20050080084A1

  公开（公告）日：2005-04-14

  The present invention provides compositions and methods for the treatment of central nervous system damage in a subject. More particularly, the invention provides a combination therapy for the treatment of a central nervous system ischemic condition or a central nervous system traumatic injury comprising the administration to a subject of a serotonin-modulating agent in combination with a cyclooxygenase-2 selective inhibitor.

  本发明提供了治疗受试者中枢神经系统损伤的组合物和方法。更具体地说，本发明提供了一种用于治疗中枢神经系统缺血性疾病或中枢神经系统创伤性损伤的组合疗法，该疗法包括向受试者施用血清素调节剂与环氧化酶-2 选择性抑制剂。
• TROXLER, F.;SEEMANN, F.
  作者：TROXLER, F.、SEEMANN, F.

  DOI：——

  日期：——
• US4340541A
  申请人：——

  公开号：US4340541A

  公开（公告）日：1982-07-20