α,2-dioxo-2H-1-benzopyran-3-acetaldehyde | 91635-05-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: α,2-dioxo-2H-1-benzopyran-3-acetaldehyde
• 英文别名: Coumarin, 3-glyoxyloyl-；2-oxo-2-(2-oxochromen-3-yl)acetaldehyde
• CAS: 91635-05-1
• 化学式: C₁₁H₆O₄
• 分子量: 202.166
• InChiKey: HGVHQIKVXUMASV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  60.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  α,2-dioxo-2H-1-benzopyran-3-acetaldehyde 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以65%的产率得到3-(2-Hydrazono-acetyl)-chromen-2-one
  参考文献：
  名称：

  El-Morsy; Fadda; El-Hossini, Journal of the Indian Chemical Society, 1988, vol. 65, # 10, p. 699 - 701

  摘要：

  DOI：
• 作为产物：
  描述：

  3-乙酰基香豆素 、 二氧化硒 以50%的产率得到
  参考文献：
  名称：

  EL-MORSY, S. S.;FADDA, A. A.;EL-HOSSINI, M. S., J. INDIAN CHEM. SOC., 65,(1988) N0, C. 699-701

  摘要：

  DOI：

文献信息

• Novel coumarin-amide derivatives and its preparation, said drug composition and its use
  申请人：Xu Shiping

  公开号：US20060148834A1

  公开（公告）日：2006-07-06

  The present invention relates to novel coumarin derivatives, their carboxamides, pharmaceutical compositions containing them and their uses as drugs for kidney protection, treating drugs of hypertension, cardio-cerebrovascular diseases, non-insulin dependent diabetes, tumor, pre-cancerous lesion, and edemas.

  本发明涉及新型香豆素衍生物，它们的羧酰胺，包含它们的制药组合物以及它们作为肾脏保护药物、治疗高血压、心脑血管疾病、非胰岛素依赖性糖尿病、肿瘤、癌前病变和水肿的用途。
• THE NOVEL COUMARIN-AMIDE DERIVATIVES AND ITS PREPARATION, SAID DRUG COMPOSITION AND ITS USE
  申请人：THE INSTITUTE OF MATERIA MEDICA OF CHINESE ACADEMY OF MEDICAL SCIENCES

  公开号：EP1570846A1

  公开（公告）日：2005-09-07

  The present invention relates to novel coumarin derivatives, their carboxamides, pharmaceutical compositions containing them and their uses as drugs for kidney protection, treating drugs of hypertension, cardio-cerebrovascular diseases, non-insulin dependent diabetes, tumor, pre-cancerous lesion, and edemas.

  本发明涉及新型香豆素衍生物、其羧酰胺、含有它们的药物组合物及其作为保护肾脏、治疗高血压、心脑血管疾病、非胰岛素依赖型糖尿病、肿瘤、癌前病变和水肿药物的用途。
• Novel 2H-chromen-2-one-3-carboxamides for medical uses
  申请人：THE INSTITUTE OF MATERIA MEDICA OF CHINESE ACADEMY OF MEDICAL SCIENCES

  公开号：EP2295053A1

  公开（公告）日：2011-03-16

  The present invention relates to novel coumarin derivatives, their carboxamides, pharmaceutical compositions containing them, and their uses as drugs for kidney protection, treating drugs of hypertension, cardio-cerebrovascular diseases, non-insulin dependent diabetes, tumor, pre-cancerous lesion, and edemas. Claimed are compounds of general formula (I): wherein R3 is selected from the group consisting , CONHR9 R4 is selected from the group consisting of hydrogen, CONHR10, R5 is selected from the group consisting of H, and C1-C4 alkyl; R6 is selected from the group consisting of H, C1-C12 alkyl, halogen, NO2, and CONHR13, R8 is selected from the group consisting of H, C1-C4 alkyl or alkoxyl, NO2. The other variables are as defined in claims.

  本发明涉及新型香豆素衍生物、它们的羧酰胺、含有它们的药物组合物，以及它们作为保护肾脏的药物、治疗高血压、心脑血管疾病、非胰岛素依赖型糖尿病、肿瘤、癌前病变和水肿的药物的用途。 所要求的是通式(I)化合物： 其中 R3 选自以下组成的组 CONHR9 R4 选自由氢、CONHR10 组成的组 R5 选自由 H 和 C1-C4 烷基组成的组； R6 选自由 H、C1-C12 烷基、卤素、NO2 和 CONHR13 组成的组、 R8选自由H、C1-C4烷基或烷氧基、NO2组成的组。 其他变量如权利要求中所定义。
• EL-MORSY, S. S.;FADDA, A. A.;EL-HOSSINI, M. S., J. INDIAN CHEM. SOC., 65,(1988) N0, C. 699-701
  作者：EL-MORSY, S. S.、FADDA, A. A.、EL-HOSSINI, M. S.

  DOI：——

  日期：——
• US8338401B2
  申请人：——

  公开号：US8338401B2

  公开（公告）日：2012-12-25