Acetic acid, nitrilotri-, trisodium salt

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Acetic acid, nitrilotri-, trisodium salt
• 英文别名: trisodium;2-[bis(carboxylatomethyl)amino]acetate
• 化学式: C6H6NNa3O6
• 分子量: 257.08
• InChiKey: DZCAZXAJPZCSCU-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
  -14.45
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  124
• 氢给体数：
  0
• 氢受体数：
  7

ADMET

毒理性

• 致癌性证据

评估：对于亚硝基三乙酸的致癌性，人类中的证据不足。对于亚硝基三乙酸及其钠盐的致癌性，实验动物中有足够证据。总体评估：亚硝基三乙酸及其盐类可能对人类具有致癌性（2B组）。/亚硝基三乙酸及其盐类/

Evaluation: There is inadequate evidence in humans for the carcinogenicity of nitrilotriacetic acid and its salts. There is sufficient evidence in experimental animals for the carcinogenicity of nitrilotriacetic acid and its sodium salts. Overall evaluation: Nitrilotriacetic acid and its salts are possibly carcinogenic in humans (Group 2B). /Nitrilotriacetic acid and its salts/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 暴露途径

该物质可以通过吸入其气溶胶和通过吞食被吸收进人体。

The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 吸入症状

灼热感。喉咙痛。咳嗽。呼吸困难。气短。

Burning sensation. Sore throat. Cough. Laboured breathing. Shortness of breath.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 皮肤症状

红肿。皮肤灼伤。疼痛。

Redness. Skin burns. Pain.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 眼睛症状

红斑。疼痛。严重的深度烧伤。

Redness. Pain. Severe deep burns.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

吸收、分配和排泄

三钠氨基三乙酸盐在大鼠和狗中吸收良好，并以不变的形式通过尿液排出。在大鼠骨骼中与钙离子结合的该物质的量（8微克/克骨骼）仅占该组织24小时钙转换的0.007%，被认为不太可能对发育产生不利影响。

TRISODIUM AMINOTRIACETATE WAS WELL ABSORBED IN RATS AND DOGS, & EXCRETED UNCHANGED IN URINE. THE AMT (8 UG/G BONE), WHICH WAS INCORPORATED INTO RAT SKELETON IN COMBINATION WITH CA2+ REPRESENTED ONLY 0.007% OF THE 24 HR TURNOVER OF CALCIUM IN THAT TISSUE, AND WAS CONSIDERED UNLIKELY TO AFFECT DEVELOPMENT ADVERSELY.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

老鼠在饮食中分别添加了0.05、0.1、0.3、0.5、0.75或2%的硝基三乙酸酯，持续42天和30天。即使在尿液中NTA水平等于或大于血浆的200倍时，硝基三乙酸酯在膀胱组织中的积累程度也不比心脏和肝脏更高。

RATS WERE GIVEN TRISODIUM NITRILOTRIACETATE AT DIETARY LEVELS OF 0.05, 0.1, 0.3, 0.5, 0.75, OR 2% FOR 42 & 30 DAYS. NITRILOTRIACETATE DID NOT ACCUMULATE IN BLADDER TISSUES TO ANY GREATER EXTENT THAN IN HEART AND LIVER, EVEN WHEN URINARY NTA LEVELS WERE EQUAL TO OR GREATER THAN 200 TIMES THOSE IN PLASMA.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

在全身自动放射性照片研究中，给NMRI白化小鼠静脉注射了0.93毫克的(1-(14)C-醋酸)NTA，三钠盐，并且给C57BI小鼠口服了相同剂量；在骨骼中发生了大量的放射性积累，这种积累持续了48小时，这是所研究的最长时间间隔。

In a whole body autoradiographic study, 0.93 Mg (1-(14)C-acetate) NTA, trisodium salt was administered intravenously to NMRI albino mice and the same amount orally to C57BI mice; heavy accumulation of radioactivity occurred in the skeleton, which persisted for 48 h, the longest interval studied.

来源:Hazardous Substances Data Bank (HSDB)

反应信息

• 作为反应物：
  描述：

  Acetic acid, nitrilotri-, trisodium salt 生成 次氮基三乙酸
  参考文献：
  名称：

  NISIBAYASI, XIDEHYUKI;JOKOYAMA, XIROMI;GOTO, TAKAKIE

  摘要：

  DOI：
• 作为产物：
  描述：

  三乙醇胺 生成 Acetic acid, nitrilotri-, trisodium salt
  参考文献：
  名称：

  GOTO, TAKAKIYO;YOKOYAMA, HIROMI;NISHIBAYASHI, HIDEYUKI

  摘要：

  DOI：

文献信息

• Process for producing granular alkali metal nitrilotriacetate
  申请人：Solutia, Inc.

  公开号：US05861531A1

  公开（公告）日：1999-01-19

  There is disclosed a process for preparing highly absorptive granular alkali metal nitrilotriacetate by contacting NTA powder with a partially neutralizing amount of acid. A granular product having a majority of the granules, by weight, in the -12 to +80 mesh size range, which have a density of at least about 0.70 g/cc and an absorptivity in the absorptivity test in the range of above 12 ml/100 g is produced by contacting alkali metal nitrilotriacetate with acid, mixing the material to granulate it and then drying the granules. The acid may be added in either one or two steps. In the one step embodiment the acid addition time/mix time ratio is critical while in the two addition step embodiment mix time is not critical. However, in the two step embodiment the powder is first contacted is with dilute acid and the second contact step is with concentrated acid. A granular product having a density of at least about 0.70 g/cc, fewer than 15% fine material and an absorptivity in the range of from about 12-14 ml/100 g is produced.

  本发明揭示了一种制备高吸收性颗粒状碱金属NTA的方法，即通过将NTA粉末与部分中和量的酸接触。通过将碱金属NTA与酸接触，混合材料以制成颗粒，并然后干燥颗粒，从而产生大多数颗粒重量在-12至+80目尺寸范围内，密度至少约为0.70 g / cc，吸收性在吸收性测试范围内大于12 ml / 100 g的颗粒产品。酸可以分为一步或两步添加。在一步实施方式中，酸添加时间/混合时间比关键，而在两步添加实施方式中，混合时间不关键。但是，在两步实施方式中，首先将粉末与稀酸接触，第二个接触步骤是与浓酸接触。产生的颗粒产品具有密度至少约为0.70 g / cc，少于15％的细颗粒，吸收性在约12-14 ml / 100 g的范围内。
• AMINOCARBOXYLATE POWDERS WITH IMPROVED PURITY AND FLOWABILITY PROPERTIES
  申请人：Moore, JR. J. W.

  公开号：US20110288332A1

  公开（公告）日：2011-11-24

  Provided is a method for preparing stable free flowing solid aminocarboxylate chelants by adding to a chelant that contains residual alkaline metal hydroxide a free or partially neutralized carboxylic acid such that the free or partially neutralized acid neutralizes at least a portion of the alkaline metal hydroxide; and isolating therefrom the free-flowing solid chelant.

  提供了一种制备稳定自由流动的固态氨基羧酸螯合剂的方法，该方法是向含有残留碱性金属氢氧化物的螯合剂中添加一个自由或部分中和的羧酸，使得自由或部分中和的酸至少中和部分碱性金属氢氧化物；然后从中分离出自由流动的固态螯合剂。
• Aminocarboxylate powders with improved purity and flowability properties
  申请人：Moore, Jr. J. Weldon

  公开号：US09012684B2

  公开（公告）日：2015-04-21

  Provided is a method for preparing stable free flowing solid aminocarboxylate chelants by adding to a chelant that contains residual alkaline metal hydroxide a free or partially neutralized carboxylic acid such that the free or partially neutralized acid neutralizes at least a portion of the alkaline metal hydroxide; and isolating therefrom the free-flowing solid chelant.

  提供了一种制备稳定自由流动的固态氨基羧酸螯合剂的方法，该方法是通过向含有残留碱性金属氢氧化物的螯合剂中添加自由或部分中和的羧酸，使得自由或部分中和的酸中和至少部分碱性金属氢氧化物；然后从中分离出自由流动的固态螯合剂。
• METAL PRECURSOR AND METAL PRECURSOR INK USING THE SAME
  申请人：PESOLVE CO., LTD.

  公开号：US20150336878A1

  公开（公告）日：2015-11-26

  Provided are a metal precursor containing an oxime group, which is represented by general formula 1, and a metal precursor ink containing same. The metal precursor ink according to the present invention enhance metal content, induce intramolecular and/or intermolecular complexation, thereby enabling low temperature sintering with excellent solubility and stability. The metal precursor ink according to the present invention can be used to form a metal wire with a desired shape. Therefore, the metal precursor ink can find applications in the field of printed electronics, particularly various electrodes, such as mesh type transparent electrodes.

  提供一种含有肟基团的金属前体，其表示为通式1，并且包含相同的金属前体油墨。本发明的金属前体油墨增强了金属含量，诱导分子内和/或分子间络合作用，从而实现低温烧结，具有优异的溶解性和稳定性。本发明的金属前体油墨可用于形成所需形状的金属线。因此，该金属前体油墨可以在印刷电子领域中找到应用，特别是各种电极，如网格型透明电极。
• SPANGGORD R. J.; TYSON C. A., SCIENCE, 1979, 204, NO 4397, 1081-1082
  作者：SPANGGORD R. J.、 TYSON C. A.

  DOI：——

  日期：——

表征谱图