5-(5-Bromo-pentyloxy)-indan | 83802-68-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 5-(5-Bromo-pentyloxy)-indan
• 英文别名: 5-(5-bromopentoxy)-2,3-dihydro-1H-indene
• CAS: 83802-68-0
• 化学式: C₁₄H₁₉BrO
• 分子量: 283.208
• InChiKey: YGPXUOCVFXZMJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5-(5-Bromo-pentyloxy)-indan 、 N-苯基哌嗪 生成 1-[5-(2,3-dihydro-1H-inden-5-yloxy)pentyl]-4-phenylpiperazine;dihydrochloride
  参考文献：
  名称：

  KIKUMOTO, RYOJI;TOBE, AKIHIRO;FUKAMI, HARUKAZU;EGAWA, MITSUO, J. MED. CHEM., 1983, 26, N 2, 246-250

  摘要：

  DOI：
• 作为产物：
  描述：

  1,5-二溴戊烷 、 5-茚醇 在 氢氧化钾 作用下， 以 水 、 叔丁醇 为溶剂， 反应 2.0h， 生成 5-(5-Bromo-pentyloxy)-indan
  参考文献：
  名称：

  Synthesis and antianxiety activity of (.omega.-piperazinylalkoxy)indan derivatives

  摘要：

  A series of (omega-piperazinylalkoxy)indan derivatives has been synthesized and screened for potential antianxiety activities. The effect of structural modification of these molecules on activities has been systemically examined. Antianxiety activity was displayed by 5-[3-(4-phenyl-1-piperazinyl)propoxy]indan (2), 5-[3-[4-(4-fluorophenyl)-1-piperazinyl]-propoxy]indan (8), 6-fluoro-5-[3-(4-phenyl-1-piperazinyl)propoxy]indan (33), and 6-methyl-5-[3-(4-phenyl-1-piperazinyl)propoxy]indan (42), as determined in antifighting and anti-morphine tests. These derivatives in antianxiety tests were equipotent or more potent than chlordiazepoxide with less muscle-relaxant effect. They also showed weak neuroleptic-like action.

  DOI：

  10.1021/jm00356a024

文献信息

• Synthesis and antianxiety activity of (.omega.-piperazinylalkoxy)indan derivatives
  作者：Ryoji Kikumoto、Akihiro Tobe、Harukazu Fukami、Mitsuo Egawa

  DOI：10.1021/jm00356a024

  日期：1983.2

  A series of (omega-piperazinylalkoxy)indan derivatives has been synthesized and screened for potential antianxiety activities. The effect of structural modification of these molecules on activities has been systemically examined. Antianxiety activity was displayed by 5-[3-(4-phenyl-1-piperazinyl)propoxy]indan (2), 5-[3-[4-(4-fluorophenyl)-1-piperazinyl]-propoxy]indan (8), 6-fluoro-5-[3-(4-phenyl-1-piperazinyl)propoxy]indan (33), and 6-methyl-5-[3-(4-phenyl-1-piperazinyl)propoxy]indan (42), as determined in antifighting and anti-morphine tests. These derivatives in antianxiety tests were equipotent or more potent than chlordiazepoxide with less muscle-relaxant effect. They also showed weak neuroleptic-like action.
• KIKUMOTO, RYOJI;TOBE, AKIHIRO;FUKAMI, HARUKAZU;EGAWA, MITSUO, J. MED. CHEM., 1983, 26, N 2, 246-250
  作者：KIKUMOTO, RYOJI、TOBE, AKIHIRO、FUKAMI, HARUKAZU、EGAWA, MITSUO

  DOI：——

  日期：——