(2S)-2-((tosyloxy)methyl)-8-methoxy-1,4-benzodioxane | 329966-27-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S)-2-((tosyloxy)methyl)-8-methoxy-1,4-benzodioxane
• 英文别名: (S)-toluene-4-sulfonic acid 8-methoxy-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl ester；[(3S)-5-methoxy-2,3-dihydro-1,4-benzodioxin-3-yl]methyl 4-methylbenzenesulfonate
• CAS: 329966-27-0
• 化学式: C₁₇H₁₈O₆S
• 分子量: 350.392
• InChiKey: FXKKOCNPTIJDIG-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  79.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (2S)-2-((tosyloxy)methyl)-8-methoxy-1,4-benzodioxane 在 sodium iodide 作用下， 以 丙酮 为溶剂， 反应 12.0h， 生成 (2S)-2-(iodomethyl)-8-methoxy-1,4-benzodioxane
  参考文献：
  名称：

  Synthesis of Homochiral 5- and 8- Substituted 2-[((2-(2,6-Dimethoxyphenoxy)- ethyl)amino)methyl]-1,4-benzodioxanes and Electrophoretic Determination of Their Enantiomeric Excess

  摘要：

  DOI：

  10.1021/jo0008340
• 作为产物：
  描述：

  2,3-二甲氧基苯酚 在 吡啶 、 盐酸 、 sodium hydroxide 、 sodium methylate 、 三氯化硼 、 potassium carbonate 作用下， 以 乙醇 、 二氯甲烷 、 丙酮 为溶剂， 反应 92.5h， 生成 (2S)-2-((tosyloxy)methyl)-8-methoxy-1,4-benzodioxane
  参考文献：
  名称：

  Synthesis of Homochiral 5- and 8- Substituted 2-[((2-(2,6-Dimethoxyphenoxy)- ethyl)amino)methyl]-1,4-benzodioxanes and Electrophoretic Determination of Their Enantiomeric Excess

  摘要：

  DOI：

  10.1021/jo0008340

文献信息

• 8-Aza-bicyclo[3.2.1]octan-3-ol derivatives of 2,3-dihydro-1,4-benodioxan as 5-HT1A antagonists
  申请人：Wyeth

  公开号：US20030032648A1

  公开（公告）日：2003-02-13

  Compounds of the formula: 1 are useful for treating the cognitive deficits due to aging, stroke, head trauma, Alzheimer's disease or other neurodegenerative diseases, or schizophrenia and also treatment of disorders related to excessive serotonergic stimulation, such as anxiety, aggression and stress, and for the control of various physiological phenomena, such as appetite, thermoregulation, sleep and sexual behavior, which are known to be, at least in part, under serotonergic influence.

  公式为1的化合物对治疗由于老化、中风、头部创伤、阿尔茨海默病或其他神经退行性疾病、精神分裂症引起的认知缺陷非常有用，同时也可用于治疗与过度5-羟色胺刺激有关的紊乱，如焦虑、攻击性和压力，以及控制各种生理现象，如食欲、体温调节、睡眠和性行为，这些现象至少部分受5-羟色胺影响。
• [EN] 8-AZA-BICYCLO[3.2.1]OCTAN-3-OL DERIVATIVES OF 2,3-DIHYDRO-1,4-BENZODIOXAN AS 5-HT1A ANTAGONISTS<br/>[FR] DERIVES DE 8-AZA-BICYCLO[3.2.1]OCTAN-3-OL DE 2,3-DIHYDRO-1,4-BENZODIOXAN UTILISES COMME ANTAGONISTES 5-HT1A
  申请人：WYETH CORP

  公开号：WO2002085900A1

  公开（公告）日：2002-10-31

  Compounds of the formula (I) are useful for treating the cognitive deficits due to aging, stroke, head trauma, Alzheimer's disease or other neurodegenerative diseases, or schizophrenia and also treatment of disorders related to excessive serotonergic stimulation, such as anxiety, aggression and stress, and for the control of various physiological phenomena, such as appetite, thermoregulation, sleep and sexual behavior, which are known the be, at least in part, under serotonergic influence.

  公式（I）的化合物对于治疗由于衰老、中风、头部创伤、阿尔茨海默病或其他神经退行性疾病、精神分裂症所引起的认知缺陷以及与过度5-羟色胺刺激有关的紊乱，如焦虑、攻击和压力，以及控制各种生理现象，如食欲、体温调节、睡眠和性行为，这些现象至少部分受到5-羟色胺影响，具有治疗作用。
• 8-AZA-bicyclo[3.2.1]octan-3-OL derivative of 2,3-dihydro-1,4-benzodioxan as 5-HT 1A antagonists
  申请人：Wyeth

  公开号：US20040063728A1

  公开（公告）日：2004-04-01

  Compounds of the formula: 1 are useful for treating the cognitive deficits due to aging, stroke, head trauma, Alzheimer's disease or other neurodegenerative diseases, or schizophrenia and also treatment of disorders related to excessive serotonergic stimulation, such as anxiety, aggression and stress, and for the control of various physiological phenomena, such as appetite, thermoregulation, sleep and sexual behavior, which are known to be, at least in part, under serotonergic influence.

  公式为1的化合物可用于治疗因衰老、中风、头部创伤、阿尔茨海默病或其他神经退行性疾病、精神分裂症引起的认知缺陷，以及过度血清素刺激相关的疾病，如焦虑、攻击和压力，并用于控制各种生理现象，如食欲、体温调节、睡眠和性行为，这些生理现象已知至少在某种程度上受到血清素影响。
• 8-aza-bicyclo&lsqb;3.2.1&rsqb;octan-3-ol derivatives of 2,3-dihydro-1,4-benzodioxan as 5-HT1A antagonists
  申请人：Wyeth

  公开号：US06656951B2

  公开（公告）日：2003-12-02

  Compounds of the formula: are useful for treating the cognitive deficits due to aging, stroke, head trauma, Alzheimer's disease or other neurodegenerative diseases, or schizophrenia and also treatment of disorders related to excessive serotonergic stimulation, such as anxiety, aggression and stress, and for the control of various physiological phenomena, such as appetite, thermoregulation, sleep and sexual behavior, which are known to be, at least in part, under serotonergic influence.

  公式为：的化合物对于治疗由于衰老、中风、头部创伤、阿尔茨海默病或其他神经退行性疾病、精神分裂症所致的认知障碍以及与过度血清素刺激有关的疾病，如焦虑、攻击性和压力等障碍，以及控制各种生理现象，如食欲、体温调节、睡眠和性行为，这些现象至少部分受到血清素影响是有效的。
• US6656951B2
  申请人：——

  公开号：US6656951B2

  公开（公告）日：2003-12-02