4-(3-Aminophenoxy)benzene-1,2-diamine | 29178-62-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(3-Aminophenoxy)benzene-1,2-diamine
• 英文别名: 4-(3-Aminophenoxy)benzen-1,2-diamin；3,3',4-triaminodiphenyl ether
• CAS: 29178-62-9
• 化学式: C₁₂H₁₃N₃O
• 分子量: 215.255
• InChiKey: ZLNMOLXMFRXCKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  87.3
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-(1H-吲哚-2-基)-3-甲氧基-1H-吡咯-2-甲醛 、 4-(3-Aminophenoxy)benzene-1,2-diamine 在 sodium hydrogensulfite 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 0.67h， 生成 3–((2-(5-(1H-indol-2-yl)-3-methoxy-1H-pyrrol-2-yl)-1Hbenzo[d]imidazol-6-yl)oxy)aniline
  参考文献：
  名称：

  Novel imidazopyridine suppresses STAT3 activation by targeting SHP-1

  摘要：

  The unregulated activation of STAT3 has been demonstrated to occur in many cancers and enhances tumour growth, migration, and invasion. Stimulation by cytokines, growth factors, and hormones triggers this activation by phosphorylating STAT3 at tyrosine 705. Novel imidazopyridine compounds were synthesized to evaluate the inhibition of STAT3 at Y705. Among the tested compounds, 16 reduced the level of phospho-STAT3, inhibited the downstream signalling cascade and subsequently attenuated the survival of hepatocellular carcinoma (HCC) cells. Further assays showed that the reduction effects of compound 16 on tyrosine 705 of STAT3 were attributed to up-regulation of protein tyrosine phosphatase SHP-1.

  DOI：

  10.1080/14756366.2018.1497019

文献信息

• METHOD FOR PRODUCING ADIPIC ACID
  申请人：TORAY INDUSTRIES, INC.

  公开号：US20220356140A1

  公开（公告）日：2022-11-10

  The present invention relates to a method of producing adipic acid, including a step (hydrogenation step) of reacting 3-hydroxyadipic acid-3,6-lactone with hydrogen in an aqueous solvent in a presence of a hydrogenation catalyst. The hydrogenation catalyst preferably includes one kind or two or more kinds of transition metal elements selected from the group consisting of palladium, platinum, ruthenium, rhodium, rhenium, nickel, cobalt, iron, iridium, osmium, copper, and chromium.

  本发明涉及一种生产己二酸的方法，包括在水溶剂中存在氢化催化剂的情况下，通过加氢反应3-羟基己二酸-3,6-内酯来进行的加氢步骤。氢化催化剂优选包括从钯、铂、钌、铑、铼、镍、钴、铁、铱、锇、铜和铬组成的过渡金属元素中选择一种或两种或更多种。
• Blockade of STAT3 activation by sorafenib derivatives through enhancing SHP-1 phosphatase activity
  作者：Kuen-Feng Chen、Wei-Tien Tai、Cheng-Yi Hsu、Jui-Wen Huang、Chun-Yu Liu、Pei-Jer Chen、InKi Kim、Chung-Wai Shiau

  DOI：10.1016/j.ejmech.2012.07.023

  日期：2012.9

  Previously, we demonstrated that the multiple kinase inhibitor sorafenib mediates the repression of phospho-STAT3 in hepatocellular carcinoma cells. In this study, we used this kinase-independent mechanism as a molecular basis to use sorafenib as scaffold to develop a novel class of SHP-1-activating agents. The proof of principle of this premise was provided by SC-1, which on replacement of N-methylpicolinamide by a phenylcyano group showed abolished kinase activity while retaining phospho-STAT3 repressive activity. Structural optimization of SC-1 led to compound 6, which repressed phospho-STAT3 through SHP-1 activation and inhibited PLC5 cell proliferation at sub-micromolar potency. In light of the pivotal role of phospho-STAT3 in promoting tumorigenesis and drug resistance, this novel SHP-1-activating agent may have therapeutic relevance in cancer therapy. (C) 2012 Elsevier Masson SAS. All rights reserved.
• Polyamic acid composite, polyimide composite and processes for producing the same
  申请人：Toho Rayon Co., Ltd.

  公开号：EP0454158B1

  公开（公告）日：2003-09-03
• LIQUID CRYSTAL ALIGNMENT AGENT, AND LIQUID CRYSTAL ALIGNMENT FILM AND LIQUID CRYSTAL DISPLAY ELEMENT FORMED FROM THE LIQUID CRYSTAL ALIGNMENT AGENT
  申请人：CHI MEI CORPORATION

  公开号：US20130281618A1

  公开（公告）日：2013-10-24

  A liquid crystal alignment agent including a polymer composition and a solvent. The polymer composition is obtained by subjecting a mixture including a tetracarboxylic dianhydride component, a multi-amine component of formula (I) defined herein, and a diamine component to a reaction. The diamine component includes a diamine compound of formula (II) defined herein.
• METHOD FOR PRODUCING PURIFIED SOYBEAN OLIGOSACCHARIDE LIQUID
  申请人：TORAY INDUSTRIES, INC.

  公开号：US20160264957A1

  公开（公告）日：2016-09-15

  A method for producing a purified soybean oligosaccharide liquid according to the present invention is a method for producing a purified soybean oligosaccharide liquid from a soybean and/or a processed soybean product, comprising: the step (1) of mixing the soybean and/or the processed soybean product with a water-containing polar organic solvent that contains a polar organic solvent and water and then removing a generated precipitate to obtain a soybean oligosaccharide liquid that contains the water-containing polar organic solvent; the step (2) of removing the polar organic solvent from the soybean oligosaccharide liquid to obtain a soybean oligosaccharide suspension; the step (3) of mixing the soybean oligosaccharide suspension with cellulase to obtain a cellulase-treated soybean oligosaccharide suspension; and the step (4) of subjecting the cellulase-treated soybean oligosaccharide suspension to solid-liquid separation to obtain a purified soybean oligosaccharide liquid.