6-[(2-chloro-6-fluorophenyl)ethyl]-5-ethyl-2-isopropylthiopyrimidin-4(3H)-one | 1613669-11-6

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 6-[(2-chloro-6-fluorophenyl)ethyl]-5-ethyl-2-isopropylthiopyrimidin-4(3H)-one
• 英文别名: 4-[1-(2-chloro-6-fluoro-phenyl)ethyl]-5-ethyl-2-isopropylsulfanyl-1H-pyrimidin-6-one；4-[1-(2-chloro-6-fluorophenyl)ethyl]-5-ethyl-2-propan-2-ylsulfanyl-1H-pyrimidin-6-one
• CAS: 1613669-11-6
• 化学式: C₁₇H₂₀ClFN₂OS
• 分子量: 354.876
• InChiKey: DDGKQZBTWCQEJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  66.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氯-6-氟苯乙酸 在 正丁基锂 、 sodium 、 potassium carbonate 、 二乙胺 、 三乙胺 、 magnesium chloride 作用下， 以 四氢呋喃 、 乙醇 、 正己烷 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 8.0h， 生成 6-[(2-chloro-6-fluorophenyl)ethyl]-5-ethyl-2-isopropylthiopyrimidin-4(3H)-one
  参考文献：
  名称：

  Exploring the Role of 2-Chloro-6-fluoro Substitution in 2-Alkylthio-6-benzyl-5-alkylpyrimidin-4(3H)-ones: Effects in HIV-1-Infected Cells and in HIV-1 Reverse Transcriptase Enzymes

  摘要：

  A comparison of the effects of the 6-(2-chloro-6-fluorobenzyl)-2-(alkylthio)pyrimidin-4(3H)-ones (2-Cl-6-F-S-DABOs) 7-12 and the related 6-(2,6-difluorobenzyl) counterparts 13-15 in HIV-1 infected cells and in the HIV-1 reverse transcriptase (RT) assays is here described. The new 2-Cl-6-F-S-DABOs showed up to picomolar activity against wt HIV-1. Against clinically relevant HIV-1 mutants and in enzyme assays, the simultaneous C5(methyl)/C6(methyl/ethyl) substitution in the 2-Cl-6-F- and 2,6-F2-benzyl series furnished compounds with the highest, wide-spectrum inhibitory activity against HIV-1. Three representative 2-Cl-6-F-S-DABOs carrying two (9c, 10c) or one (10a) stereogenic centers were resolved into their individual stereoisomers and showed a significant diastereo- and enantioselectivity in HIV-1 inhibition, the highest antiviral activity well correlating with the R absolute configuration to the stereogenic center of the C6-benzylic position in both cellular and enzymatic tests. Application of previously reported COMBINEr protocol on 9c and 10c confirmed the influence of the stereogenic centers on their binding modes in the HIV-1 RT.

  DOI：

  10.1021/jm500284x