4,4,5,5,6,6,6-heptafluoro-hexanoic acid amide | 647-88-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4,4,5,5,6,6,6-heptafluoro-hexanoic acid amide
• 英文别名: 4,4,5,5,6,6,6-Heptafluor-hexansaeure-amid；4,4,5,5,6,6,6-Heptafluorohexanamide
• CAS: 647-88-1
• 化学式: C₆H₆F₇NO
• 分子量: 241.109
• InChiKey: JYAXOOZJMDMPCU-UHFFFAOYSA-N

物化性质

• 沸点：
  173.5±40.0 °C(Predicted)
• 密度：
  1.446±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  4,4,5,5,6,6-六氟己酸 在 氯化亚砜 、 氨 、 水 作用下， 生成 4,4,5,5,6,6,6-heptafluoro-hexanoic acid amide
  参考文献：
  名称：

  Suicidal behavior—symptom or disorder?

  摘要：

  This article examines the diagnostic status of suicidal ideation with and without additional signs of defined or subthreshold mental disorders. Data from the World Health Organization (WHO) study on Psychological Problems in General Health Care (PPGHC) show that 8.8% of all general practice patients report that they recently had a wish to be dead. Among patients with acute depressive episodes, the rate is 34.5%, as compared with 1.3% in persons without any sign of mental disorder. Rates of suicidal ideation in persons with subthreshold disorders (10.4%) are similar to the rate in persons with other, nondepressed forms of mental disorders (12.9%). Still, 30.1% of all persons with suicidal ideation do not have a defined mental disorder, and 21.5% do not even have subthreshold disorders. But in these persons also, suicidal ideation is associated with an increased rate of depressive complaints. Suicidal ideation therefore, in any case, can be seen as an indicator of mental problems. But it seems impossible to lower the thresholds of defined mental disorders so that all forms of suicidal ideation will be covered. Instead, suicidal thoughts must be regarded as a symptom with the status of a disorder itself which should be handled as a comorbid condition if other mental disorders co-occur, Copyright (C) 2000 by W.B. Saunders Company.

  DOI：

  10.1016/s0010-440x(00)80017-6

文献信息

• Methods for Making Functionalized Fluorinated Monomers, Fluorinated Monomers, and Compositions for Making the Same
  申请人：Etna-TEC, Ltd.

  公开号：US20180334417A1

  公开（公告）日：2018-11-22

  A method of making a functionalized fluorinated monomer for use in making oligomers and polymers that can be used to improve surface properties of polymer-derived systems, such as coatings. The method of making a functionalized fluorinated monomer includes reacting at least one fluorinated nucleophilic reactant, such as a fluorinated alcohol, with at least one compound containing at least one epoxide group. Other methods include reaction of a fluorinated alcohol with a cyclic carboxylic anhydride. In another embodiment, a method includes reacting a fluorinated mesylate, tosylate or triflate with an amine, alkoxide or phenoxide. In other embodiments, the method includes reacting a fluorinated alcohol with an alkyl halide, or reacting a fluorinated alkyl halide with an amine. The functionalized fluorinated monomers may be used as intermediates and reacted to modify the functional groups thereon. Further, the functionalized fluorinated monomers may be reacted to form polymers or oligomers, or with polymers or oligomers having functional groups to modify the polymer or oligomer through the functional group thereon,

  一种制备用于制备寡聚物和聚合物的官能化氟化单体的方法，可用于改善聚合物衍生系统（如涂层）的表面性能。制备官能化氟化单体的方法包括将至少一种氟化亲核试剂（如氟化醇）与至少一种含有至少一个环氧基团的化合物反应。其他方法包括将氟化醇与环状羧酸酐反应。在另一实施例中，一种方法包括将氟化甲磺酸酯、对甲苯磺酸酯或三氟甲烷磺酸酯与胺、烷氧基或苯氧基反应。在其他实施例中，该方法包括将氟化醇与烷基卤化物反应，或将氟化烷基卤化物与胺反应。这些官能化氟化单体可用作中间体，并可反应以修改其上的官能基团。此外，这些官能化氟化单体可用于与聚合物或寡聚物反应，或与具有官能基团的聚合物或寡聚物反应，通过其上的官能基团修改聚合物或寡聚物。
• METHODS FOR MAKING FUNCTIONALIZED FLUORINATED MONOMERS, FLUORINATED MONOMERS, AND COMPOSITIONS FOR MAKING THE SAME
  申请人：Etna-Tec, Ltd

  公开号：EP3635022A1

  公开（公告）日：2020-04-15
• [EN] METHODS FOR MAKING FUNCTIONALIZED FLUORINATED MONOMERS, FLUORINATED MONOMERS, AND COMPOSITIONS FOR MAKING THE SAME<br/>[FR] PROCÉDÉS DE PRÉPARATION DE MONOMÈRES FLUORÉS FONCTIONNALISÉS, MONOMÈRES FLUORÉS ET COMPOSITIONS POUR LES PRÉPARER
  申请人：ETNA TEC LTD

  公开号：WO2018213850A1

  公开（公告）日：2018-11-22

  A method of making a fimctionalized fluonnated monomer for use in making oligomers and polymers that can be used to improve surface properties of polymer-derived systems, such as coatings. The method of making a fimctionalized fluonnated monomer includes reacting at least one fluorinated rmcleophilic reactant, such as a fluonnated alcohol, with at least one compound containing at least one epoxide group. Other methods include reaction of a fluorinated alcohol with a cyclic carboxylic anhydride. In another embodiment, a method includes reacting a fluonnated mesylate, tosyfate or triflate with an amine, alkoxide or phenoxide. In other embodiments, the method includes reacting a fluorinated alcohol with an alkyl hali.de. or reacting a fluorinated alkyl halide with an amine. The fimctionalized fluonnated monomers may be used as intermediates and reacted to modify the functional groups thereon. Further, the functional] zed fluorinated monomers may be reacted to form polymers or oligomers, or with polymers or oligomers having functional groups to modify the polymer or oligomer through the functional group thereon.