4-methoxydinaphtho[1,2-b:1',2'-d]furan-5,8-diyl diacetate | 1620648-71-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并呋喃类
• 英文名称: 4-methoxydinaphtho[1,2-b:1',2'-d]furan-5,8-diyl diacetate
• CAS: 1620648-71-6
• 化学式: C₂₅H₁₈O₆
• 分子量: 414.414
• InChiKey: REPLSQLIZQVTJD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.75
• 重原子数：
  31.0
• 可旋转键数：
  3.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  74.97
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  4-methoxydinaphtho[1,2-b:1',2'-d]furan-5,8-diyl diacetate 在 二异丁基氢化铝 作用下， 以 正己烷 、 二氯甲烷 为溶剂， 反应 0.25h， 以83%的产率得到xylarianaphthol-1
  参考文献：
  名称：

  Xylarianaphthol-1, a novel dinaphthofuran derivative, activates p21 promoter in a p53-independent manner

  摘要：

  Xylarianaphthol-1, a novel dinaphthofuran derivative, was isolated from a marine sponge-derived fungus of order Xylariales on the guidance of a bioassay using the transfected human osteosarcoma MG63 cells (MG63(luc+)). The chemical structure of xylarianaphthol-1 was determined from the H-1 and C-13 NMR analysis and was further confirmed by the total synthesis. Xylarianaphthol-1 activated p21 promoter stably transfected in MG63 cells dose-dependently. Expression of p21 protein in the wild-type MG63 cells was also increased by xylarianaphthol-1 treatment. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.05.083
• 作为产物：
  描述：

  4-methoxy-11-(((trifluoromethyl)sulfonyl)oxy)dinaphtho[1,2-b:1',2'-d]furan-5,8-diyl diacetate 在 palladium diacetate 、 三乙胺 、 三苯基膦 、 甲酸 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.58h， 以87%的产率得到4-methoxydinaphtho[1,2-b:1',2'-d]furan-5,8-diyl diacetate
  参考文献：
  名称：

  Xylarianaphthol-1, a novel dinaphthofuran derivative, activates p21 promoter in a p53-independent manner

  摘要：

  Xylarianaphthol-1, a novel dinaphthofuran derivative, was isolated from a marine sponge-derived fungus of order Xylariales on the guidance of a bioassay using the transfected human osteosarcoma MG63 cells (MG63(luc+)). The chemical structure of xylarianaphthol-1 was determined from the H-1 and C-13 NMR analysis and was further confirmed by the total synthesis. Xylarianaphthol-1 activated p21 promoter stably transfected in MG63 cells dose-dependently. Expression of p21 protein in the wild-type MG63 cells was also increased by xylarianaphthol-1 treatment. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.05.083