N-{2-[4-(4-Chloro-butyl)-phenyl]-ethyl}-acetamide | 287174-95-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-{2-[4-(4-Chloro-butyl)-phenyl]-ethyl}-acetamide
• 英文别名: N-[2-[4-(4-chlorobutyl)phenyl]ethyl]acetamide
• CAS: 287174-95-2
• 化学式: C₁₄H₂₀ClNO
• 分子量: 253.772
• InChiKey: QRZJRSZEMUMQNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-苯基哌嗪 、 N-{2-[4-(4-Chloro-butyl)-phenyl]-ethyl}-acetamide 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 N-(2-{4-[4-(4-Phenyl-piperazin-1-yl)-butyl]-phenyl}-ethyl)-acetamide
  参考文献：
  名称：

  Novel phenylpiperazine derivatives as dual cytokine regulators with TNF-α suppressing and IL-10 augmenting activity

  摘要：

  Phenylpiperazine derivatives were synthesized as dual cytokine regulators with TNF-alpha suppressing and IL-10 augmenting activity. Lead optimization led to compound 5k having the potent regulatory activity and demonstrating remarkable protective effects against the lethal challenge of LPS in mice, suggesting that 5k would be a promising drug candidate for the treatment of TNF-alpha associated diseases including septic shock. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00128-1
• 作为产物：
  描述：

  N-{2-[4-(4-chlorobutanoyl)phenyl]ethyl}acetamide 在 三乙基硅烷 、 三氟乙酸 作用下， 生成 N-{2-[4-(4-Chloro-butyl)-phenyl]-ethyl}-acetamide
  参考文献：
  名称：

  Novel phenylpiperazine derivatives as dual cytokine regulators with TNF-α suppressing and IL-10 augmenting activity

  摘要：

  Phenylpiperazine derivatives were synthesized as dual cytokine regulators with TNF-alpha suppressing and IL-10 augmenting activity. Lead optimization led to compound 5k having the potent regulatory activity and demonstrating remarkable protective effects against the lethal challenge of LPS in mice, suggesting that 5k would be a promising drug candidate for the treatment of TNF-alpha associated diseases including septic shock. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00128-1

文献信息

• Novel phenylpiperazine derivatives as dual cytokine regulators with TNF-α suppressing and IL-10 augmenting activity
  作者：Tokushi Hanano、Kunitomo Adachi、Yoshiyuki Aoki、Hiroshi Morimoto、Yoichi Naka、Masao Hisadome、Tetsuko Fukuda、Hiroshi Sumichika

  DOI：10.1016/s0960-894x(00)00128-1

  日期：2000.5

  Phenylpiperazine derivatives were synthesized as dual cytokine regulators with TNF-alpha suppressing and IL-10 augmenting activity. Lead optimization led to compound 5k having the potent regulatory activity and demonstrating remarkable protective effects against the lethal challenge of LPS in mice, suggesting that 5k would be a promising drug candidate for the treatment of TNF-alpha associated diseases including septic shock. (C) 2000 Elsevier Science Ltd. All rights reserved.