6-acetyl-2-amino-4-(4-chlorophenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine | 144507-17-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-acetyl-2-amino-4-(4-chlorophenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine
• 英文别名: 1-[2-amino-4-(4-chlorophenyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]ethanone
• CAS: 144507-17-5
• 化学式: C₁₅H₁₅ClN₄O
• 分子量: 302.763
• InChiKey: RUPHNQVPINXKDQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  72.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-acetyl-2-amino-4-(4-chlorophenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine 在 盐酸 作用下， 反应 12.0h， 以91%的产率得到2-amino-4-(4-chlorophenyl)-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidine dihydrochloride
  参考文献：
  名称：

  Novel tetrahydropyrido[4,3-d]pyrimidines as gastric antilesion agents

  摘要：

  A variety of substituted tetrahydropyrido[4,3-d]pyrimidines was prepared and found to possess gastric antilesion against ethanol-induced lesions in rats. The more potent compounds possessed similar activity against aspirin-induced gastric lesions. A selective group of compounds was determined to be inactive as gastric antisecretory agents in rabbit isolated parietal cells. The antilesion properties of these tetrahydropyrido[4,3-d]pyrimidines make them a potential alternative to prostaglandin therapy for gastric antilesion therapy and may have clinical utility in peptic ulcer disease.

  DOI：

  10.1016/0223-5234(92)90085-f
• 作为产物：
  描述：

  N-乙酰基-4-哌啶酮 在 盐酸 、 sodium ethanolate 、 对甲苯磺酸 、 三乙胺 作用下， 以 乙醇 、 二氯甲烷 、 苯 为溶剂， 反应 22.5h， 生成 6-acetyl-2-amino-4-(4-chlorophenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine
  参考文献：
  名称：

  Novel tetrahydropyrido[4,3-d]pyrimidines as gastric antilesion agents

  摘要：

  A variety of substituted tetrahydropyrido[4,3-d]pyrimidines was prepared and found to possess gastric antilesion against ethanol-induced lesions in rats. The more potent compounds possessed similar activity against aspirin-induced gastric lesions. A selective group of compounds was determined to be inactive as gastric antisecretory agents in rabbit isolated parietal cells. The antilesion properties of these tetrahydropyrido[4,3-d]pyrimidines make them a potential alternative to prostaglandin therapy for gastric antilesion therapy and may have clinical utility in peptic ulcer disease.

  DOI：

  10.1016/0223-5234(92)90085-f

文献信息

• US5137890A
  申请人：——

  公开号：US5137890A

  公开（公告）日：1992-08-11
• Novel tetrahydropyrido[4,3-d]pyrimidines as gastric antilesion agents
  作者：PJ Sanfilippo、M Urbanski、L Williams、JB Press、LB Katz、DA Shriver、JA Fernandez、D Shatynski、SJ Offord

  DOI：10.1016/0223-5234(92)90085-f

  日期：1992.10

  A variety of substituted tetrahydropyrido[4,3-d]pyrimidines was prepared and found to possess gastric antilesion against ethanol-induced lesions in rats. The more potent compounds possessed similar activity against aspirin-induced gastric lesions. A selective group of compounds was determined to be inactive as gastric antisecretory agents in rabbit isolated parietal cells. The antilesion properties of these tetrahydropyrido[4,3-d]pyrimidines make them a potential alternative to prostaglandin therapy for gastric antilesion therapy and may have clinical utility in peptic ulcer disease.