N-isobutyryl-6-aminohexanoic acid | 149230-72-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-isobutyryl-6-aminohexanoic acid
• 英文别名: 6-(2-Methylpropanoylamino)hexanoic acid
• CAS: 149230-72-8
• 化学式: C₁₀H₁₉NO₃
• mdl: MFCD09730825
• 分子量: 201.266
• InChiKey: RGOGQIUWCJBNRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-氯-3-氧代丙酸叔丁酯 、 丁炔二酸二乙酯 、 N-isobutyryl-6-aminohexanoic acid 生成 5-Isopropyl-furan-2,3,4-tricarboxylic acid 2-tert-butyl ester 3,4-diethyl ester
  参考文献：
  名称：

  化学选择性铑（II）介导的固相1，3-偶极环加成反应及其在热自裂解呋喃支架中的应用

  摘要：

  描述了在固相上化学选择性的铑（II）介导的1,3-偶极环加成反应，用于构建模板导向的支架。在本文中，提出了乙炔与异氰酸酯的反应作为呋喃基文库组合形成的一般方法。另外，通过开发新的热裂解步骤，该呋喃合成以依赖温度的方式从固相产生纯产物。

  DOI：

  10.1016/s0040-4039(97)01768-1

文献信息

• POLYMER PARTICLES
  申请人：MicroVention, Inc.

  公开号：US20180085487A1

  公开（公告）日：2018-03-29

  Described are polymers and methods of forming and using same.

  描述了聚合物及其形成和使用方法。
• BENZO-FUSED OXAZEPINE COMPOUNDS AS STEAROYL-COENZYME A DELTA-9 DESATURASE INHIBITORS
  申请人：Shipps, JR. Gerald W.

  公开号：US20120220567A1

  公开（公告）日：2012-08-30

  The present invention relates to certain 4,5-dihydro-3H-spiro[benzo[b]-[1,4]oxazepine compounds of the Formula (I) or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , m, n, o, and p are as herein described. In addition, the invention relates to compositions comprising at least one such compound, and methods of using the compounds for treating or preventing disorders such as non-insulin dependent (Type 2) diabetes, insulin resistance, hyperglycemia, a lipid disorder, obesity, fatty liver disease, or a skin disorder.

  本发明涉及公式(I)或其药学上可接受的盐的某些4,5-二氢-3H-螺[苯[b]-[1,4]噁唑啉化合物，其中R1、R2、R3、R4、R5、m、n、o和p如本文所述。此外，本发明涉及至少含有一种这样的化合物的组合物，以及使用这些化合物治疗或预防非胰岛素依赖性（2型）糖尿病、胰岛素抵抗、高血糖、脂质代谢紊乱、肥胖症、脂肪肝病或皮肤疾病的方法。
• Composition containing a penem or carbapenem antibiotic
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0226304B1

  公开（公告）日：1991-08-28
• ENTERIC ELASTOMERS
  申请人：Massachusetts Institute of Technology

  公开号：US20170128576A1

  公开（公告）日：2017-05-11

  Enteric elastomers and related methods are generally provided. In some embodiments, the enteric elastomer is a polymer composite. Certain embodiments comprise a polymer composite in which hydrogen bonds within two carboxyl group-containing polymers cross-link the polymer networks into an elastic and pH-responsive polymer composite. Advantageously, this polymer composite has the capacity of being stable and elastic in an acidic environment such as that of the stomach but can be dissolved in a neutral pH environment such as that of the small and large intestines. In some embodiments, the polymer composites described herein comprise a mixture of two or more polymers with carboxyl functionality such that the two or more polymers form hydrogen bonds. In certain embodiments, the polymer composite has both enteric and elastic properties.
• US4757066A
  申请人：——

  公开号：US4757066A

  公开（公告）日：1988-07-12