4-cyclohexyl-piperidine-1,4-dicarboxylic acid 1-monobenzyl ester | 363191-00-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-cyclohexyl-piperidine-1,4-dicarboxylic acid 1-monobenzyl ester
• 英文别名: N-Cbz-4-cyclohexyl-piperidine-4-carboxylic acid；N-(benzyloxycarbonyl)-4-cyclohexyl-piperidine-4-carboxylic acid；4-cyclohexyl-1-phenylmethoxycarbonylpiperidine-4-carboxylic acid
• CAS: 363191-00-8
• 化学式: C₂₀H₂₇NO₄
• 分子量: 345.439
• InChiKey: CSEWDEGVOMTSQR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  66.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-cyclohexyl-piperidine-1,4-dicarboxylic acid 1-monobenzyl ester 在 草酰氯 、 氢溴酸 作用下， 以 DMF (N,N-dimethyl-formamide) 、 二氯甲烷 、 溶剂黄146 为溶剂， 反应 2.75h， 生成 N-(tert-butyl)-4-cyclohexylpiperidine-4-carboxamide
  参考文献：
  名称：

  [EN] PIPERAZINE UREA DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS
  [FR] DERIVES D'UREE DE PIPERAZINE UTILISES COMME AGONISTES DES RECEPTEURS DE MELANOCORTINE-4

  摘要：

  某些新型哌嗪脲衍生物是人类黑色素皮质素-4受体（MC-4R）的激动剂，特别是MC-4R的受体亚型选择性激动剂。它们对于治疗、控制或预防对MC-4R激活敏感的疾病和疾病是有用的，例如肥胖症和糖尿病。

  公开号：

  WO2004024720A1
• 作为产物：
  描述：

  在 溶剂黄146 、 sodium nitrite 作用下， 以 二甲基亚砜 为溶剂， 生成 4-cyclohexyl-piperidine-1,4-dicarboxylic acid 1-monobenzyl ester
  参考文献：
  名称：

  Melanocortin subtype 4 receptor agonists: Structure–activity relationships about the 4-alkyl piperidine core

  摘要：

  SAR about the piperidine core in a series of MC4R agonists is described. A number of alkyl substituents that furnish compounds with good affinity and functional potency are reported. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.11.084

文献信息

• Substituted piperidines as melanocortin receptor agonists
  申请人：——

  公开号：US20020019523A1

  公开（公告）日：2002-02-14

  Certain novel substituted piperidine compounds are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

  某些新型取代吡啶化合物是人类黑色素皮质素受体的激动剂，特别是是人类黑色素皮质素-4受体（MC-4R）的选择性激动剂。因此，它们可用于治疗、控制或预防对MC-4R激活有反应的疾病和障碍，例如肥胖症、糖尿病、性功能障碍，包括勃起功能障碍和女性性功能障碍。
• [EN] SUBSTITUTED PIPERIDINES AS MELANOCORTIN RECEPTOR AGONISTS<br/>[FR] PIPERIDINES SUBSTITUEES EN TANT QU'AGONISTES DU RECEPTEUR DE LA MELANOCORTINE
  申请人：MERCK & CO INC

  公开号：WO2001070708A1

  公开（公告）日：2001-09-27

  Certain novel substituted piperidine compounds are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

  某些新型取代哌啶化合物是人类黑色素皮质素受体的激动剂，特别是是人类黑色素皮质素-4受体（MC-4R）的选择性激动剂。因此，它们可用于治疗、控制或预防对MC-4R激活有响应的疾病和障碍，如肥胖症、糖尿病、性功能障碍（包括勃起功能障碍和女性性功能障碍）。
• Acylated piperidine derivatives as melanocortin-4 receptor modulators
  申请人：Bakshi Raman K.

  公开号：US20090253744A1

  公开（公告）日：2009-10-08

  Certain novel N-acylated spiropiperidine derivatives are ligands of the human melanocortin receptor(s) and, in particular, are selective ligands of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of MC-4R, such as obesity, diabetes, nicotine addiction, alcoholism, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

  某些新型N-酰化的螺环吡啶衍生物是人类黑色素细胞素受体的配体，特别是人类黑色素细胞素-4受体（MC-4R）的选择性配体。因此，它们可用于治疗、控制或预防对MC-4R调节敏感的疾病和障碍，如肥胖症、糖尿病、尼古丁成瘾、酗酒、性功能障碍，包括勃起功能障碍和女性性功能障碍。
• Piperazine urea derivatives as melanocortin-4 receptor agonists
  申请人：Bakshi Kumar Raman

  公开号：US20060040906A1

  公开（公告）日：2006-02-23

  Certain novel piperazine urea derivatives are agonists of the human melanocortin-4 receptor (MC-4R) and, in particular, are receptor-subtype selective agonists of MC-4R. They are useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity and diabetes.

  某些新型哌嗪脲衍生物是人类黑皮素-4 受体（MC-4R）的激动剂，尤其是 MC-4R 的受体亚型选择性激动剂。它们可用于治疗、控制或预防对 MC-4R 激活有反应的疾病和紊乱，如肥胖症和糖尿病。
• WO2008/39418
  申请人：——

  公开号：——

  公开（公告）日：——