3-methoxy-4-(α-tetrahydropyranyloxy)nitrobenzene | 102683-57-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-methoxy-4-(α-tetrahydropyranyloxy)nitrobenzene
• 英文别名: 2-(2-methoxy-4-nitrophenoxy)oxane
• CAS: 102683-57-8
• 化学式: C₁₂H₁₅NO₅
• 分子量: 253.255
• InChiKey: FWKXZZBXDRYBCX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.51
• 重原子数：
  18.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  70.83
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  3-methoxy-4-(α-tetrahydropyranyloxy)nitrobenzene 在 palladium on activated charcoal 氢氧化钾 、 Dowex 50W (H¹⁺) resin 、 氢气 作用下， 以 甲醇 、 二甲基亚砜 为溶剂， 25.0 ℃ 、303.98 kPa 条件下， 反应 5.5h， 生成 3'-methoxy-4'-hydroxy-N-methylacetanilide
  参考文献：
  名称：

  Comparative toxicities and analgesic activities of three monomethylated analogs of acetaminophen

  摘要：

  Three monomethylated derivatives of 4'-hydroxyacetanilide (acetaminophen) were prepared in order to compare their cytotoxic potential and analgesic activity with that of acetaminophen. Only 4'-hydroxy-N-methylacetanilide (N-methylacetaminophen) was devoid of cytotoxic effects to hepatic tissue of mice. Results of comparative tissue distribution studies and metabolism studies both in vivo and in vitro in mice indicate that the disposition of N-methylacetaminophen is similar to that of acetaminophen except that it is not oxidized to a toxic metabolite. In contrast, 3'-methyl-4'-hydroxyacetanilide (3-methylacetaminophen) is as hepatotoxic as acetaminophen in mice while 2'-methyl-4'-hydroxyacetanilide (2-methylacetaminophen) is less hepatotoxic. The analgesic potency of the analogues seems to parallel their hepatotoxic potential, and both activities parallel the oxidation potentials in this series of compounds.

  DOI：

  10.1021/jm00159a029
• 作为产物：
  描述：

  1,2-二甲氧基-4-硝基苯 在 盐酸 、 氢氧化钾 作用下， 以 乙酸乙酯 为溶剂， 反应 42.0h， 生成 3-methoxy-4-(α-tetrahydropyranyloxy)nitrobenzene
  参考文献：
  名称：

  Comparative toxicities and analgesic activities of three monomethylated analogs of acetaminophen

  摘要：

  Three monomethylated derivatives of 4'-hydroxyacetanilide (acetaminophen) were prepared in order to compare their cytotoxic potential and analgesic activity with that of acetaminophen. Only 4'-hydroxy-N-methylacetanilide (N-methylacetaminophen) was devoid of cytotoxic effects to hepatic tissue of mice. Results of comparative tissue distribution studies and metabolism studies both in vivo and in vitro in mice indicate that the disposition of N-methylacetaminophen is similar to that of acetaminophen except that it is not oxidized to a toxic metabolite. In contrast, 3'-methyl-4'-hydroxyacetanilide (3-methylacetaminophen) is as hepatotoxic as acetaminophen in mice while 2'-methyl-4'-hydroxyacetanilide (2-methylacetaminophen) is less hepatotoxic. The analgesic potency of the analogues seems to parallel their hepatotoxic potential, and both activities parallel the oxidation potentials in this series of compounds.

  DOI：

  10.1021/jm00159a029

文献信息

• HARVISON P. J.; FORTE A. J.; NELSON S. D., J. MED. CHEM., 29,(1986) N 9, 1737-1743
  作者：HARVISON P. J.、 FORTE A. J.、 NELSON S. D.

  DOI：——

  日期：——