2-amino-5-bromo-4,6-bis(2-hydroxyethoxy)pyrimidine | 1160513-66-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-amino-5-bromo-4,6-bis(2-hydroxyethoxy)pyrimidine
• 英文别名: 2-[2-Amino-5-bromo-6-(2-hydroxyethoxy)pyrimidin-4-yl]oxyethanol
• CAS: 1160513-66-5
• 化学式: C₈H₁₂BrN₃O₄
• 分子量: 294.105
• InChiKey: DKNOMERFCYSUIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  111
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-amino-5-bromo-4,6-bis(2-hydroxyethoxy)pyrimidine 、 hexadecyloxyethyl toluenesulfonyloxymethylphosphonate, sodium salt 在 4-二甲氨基吡啶 、 sodium hydride 作用下， 以 四氢呋喃 、 paraffin oil 为溶剂， 反应 16.5h， 以26%的产率得到2-(hexadecyloxy)ethyl-2-amino-5-bromo-4-(2-hydroxyethoxy)-6-[2-(phosphonomethoxy)ethoxy]pyrimidine sodium salt
  参考文献：
  名称：

  Acyclic nucleoside bisphosphonates: Synthesis and properties of chiral 2-amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines

  摘要：

  2-Amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines bearing two equal or different achiral or chiral phosphonoalkoxy chains have been prepared either by aromatic nucleophilic substitution of 2-amino-4,6-dichloropyrimidine or by alkylation of 4,6-dihydroxy-2-(methylsulfanyl)pyrimidine with appropriate phosphonate-bearing building block. Alkylation of 4,6-dihydroxy-2-(methylsulfanyl)pyrimidine proved to be the method of choice for efficient preparation of variety of bisphosphonates. The enantiomeric purity of selected compounds was determined by capillary electrophoresis. Antiviral activity of bisphosphonates is discussed. (C) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.09.031
• 作为产物：
  描述：

  2-amino-4,6-bis(2-hydroxyethoxy)pyrimidine 在 溴 作用下， 以 四氯化碳 、 N,N-二甲基甲酰胺 为溶剂， 以39%的产率得到2-amino-5-bromo-4,6-bis(2-hydroxyethoxy)pyrimidine
  参考文献：
  名称：

  Acyclic nucleoside bisphosphonates: Synthesis and properties of chiral 2-amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines

  摘要：

  2-Amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines bearing two equal or different achiral or chiral phosphonoalkoxy chains have been prepared either by aromatic nucleophilic substitution of 2-amino-4,6-dichloropyrimidine or by alkylation of 4,6-dihydroxy-2-(methylsulfanyl)pyrimidine with appropriate phosphonate-bearing building block. Alkylation of 4,6-dihydroxy-2-(methylsulfanyl)pyrimidine proved to be the method of choice for efficient preparation of variety of bisphosphonates. The enantiomeric purity of selected compounds was determined by capillary electrophoresis. Antiviral activity of bisphosphonates is discussed. (C) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.09.031

文献信息

• Acyclic nucleoside bisphosphonates: Synthesis and properties of chiral 2-amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines
  作者：Petra Doláková、Martin Dračínský、Milena Masojídková、Veronika Šolínová、Václav Kašička、Antonín Holý

  DOI：10.1016/j.ejmech.2008.09.031

  日期：2009.6

  2-Amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines bearing two equal or different achiral or chiral phosphonoalkoxy chains have been prepared either by aromatic nucleophilic substitution of 2-amino-4,6-dichloropyrimidine or by alkylation of 4,6-dihydroxy-2-(methylsulfanyl)pyrimidine with appropriate phosphonate-bearing building block. Alkylation of 4,6-dihydroxy-2-(methylsulfanyl)pyrimidine proved to be the method of choice for efficient preparation of variety of bisphosphonates. The enantiomeric purity of selected compounds was determined by capillary electrophoresis. Antiviral activity of bisphosphonates is discussed. (C) 2008 Elsevier Masson SAS. All rights reserved.