Naphthalene-2-carboxylic acid {(R)-4-[((S)-2-ethoxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-methyl]-1,1,5-trioxo-1λ⁶-[1,4]thiazepan-6-yl}-amide | 911304-58-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Naphthalene-2-carboxylic acid {(R)-4-[((S)-2-ethoxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-methyl]-1,1,5-trioxo-1λ⁶-[1,4]thiazepan-6-yl}-amide
• CAS: 911304-58-0
• 化学式: C₂₄H₂₇N₃O₈S
• 分子量: 517.56
• InChiKey: WMCPOEFSOGYUAM-QHEXFSSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.01
• 重原子数：
  36.0
• 可旋转键数：
  7.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  148.18
• 氢给体数：
  2.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  Naphthalene-2-carboxylic acid {(R)-4-[((S)-2-ethoxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-methyl]-1,1,5-trioxo-1λ⁶-[1,4]thiazepan-6-yl}-amide 在 三氟乙酸 作用下， 以 乙腈 为溶剂， 以41%的产率得到Naphthalene-2-carboxylic acid {(R)-4-[((S)-2-hydroxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-methyl]-1,1,5-trioxo-1λ⁶-[1,4]thiazepan-6-yl}-amide
  参考文献：
  名称：

  Synthesis and evaluation of thiazepines as interleukin-1β converting enzyme (ICE) inhibitors

  摘要：

  A series of monocyclic thiazepine inhibitors of interleukin-1 beta converting enzyme (ICE) were synthesized in eight steps from commercially available intermediates. In vitro biological evaluation showed the thiazepines to be moderately potent ICE inhibitors, with the most active compound exhibiting an IC50 value of 30 nM in an enzyme inhibition assay. Compounds of this class possessed good selectivity against the related enzymes caspase-3 and caspase-8. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.07.016
• 作为产物：
  描述：

  Naphthalene-2-carboxylic acid {(R)-4-[((S)-2-ethoxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-methyl]-5-oxo-[1,4]thiazepan-6-yl}-amide 在 碳酸氢钠 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以96%的产率得到Naphthalene-2-carboxylic acid {(R)-4-[((S)-2-ethoxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-methyl]-1,1,5-trioxo-1λ⁶-[1,4]thiazepan-6-yl}-amide
  参考文献：
  名称：

  Synthesis and evaluation of thiazepines as interleukin-1β converting enzyme (ICE) inhibitors

  摘要：

  A series of monocyclic thiazepine inhibitors of interleukin-1 beta converting enzyme (ICE) were synthesized in eight steps from commercially available intermediates. In vitro biological evaluation showed the thiazepines to be moderately potent ICE inhibitors, with the most active compound exhibiting an IC50 value of 30 nM in an enzyme inhibition assay. Compounds of this class possessed good selectivity against the related enzymes caspase-3 and caspase-8. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.07.016