4-(4-vinylbenzyloxy)benzyl bromide | 286374-29-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(4-vinylbenzyloxy)benzyl bromide
• 英文别名: 1-(Bromomethyl)-4-[(4-ethenylphenyl)methoxy]benzene
• CAS: 286374-29-6
• 化学式: C₁₆H₁₅BrO
• 分子量: 303.198
• InChiKey: WOANCAYDUZAHJC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-(4-vinylbenzyloxy)benzyl bromide 、 (1R,2R)-1,2-二苯基乙二胺 以 N,N-二甲基甲酰胺 为溶剂， 以71%的产率得到(1R,2R)-N'-[[4-[(4-ethenylphenyl)methoxy]phenyl]methyl]-1,2-diphenylethane-1,2-diamine
  参考文献：
  名称：

  Polymer-Immobilized Catalyst for Asymmetric Hydrogenation of Racemic α-(N-Benzoyl-N-methylamino)propiophenone

  摘要：

  Asymmetric hydrogenation of alpha-(N-benzoyl-N-methylamino)propiophenone through dynamic kinetic resolution was performed by using a polymer-immobilized chiral diamine-ruthenium-BINAP-t-BuOK system in order to yield syn-beta-amide alcohol exclusively with nearly perfect enantioselectivity.

  DOI：

  10.1021/jo802339t
• 作为产物：
  描述：

  p-hydroxymethylphenyl 4-vinylbenzyl ether 在 四溴化碳 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 以90%的产率得到4-(4-vinylbenzyloxy)benzyl bromide
  参考文献：
  名称：

  Polymer-Immobilized Catalyst for Asymmetric Hydrogenation of Racemic α-(N-Benzoyl-N-methylamino)propiophenone

  摘要：

  Asymmetric hydrogenation of alpha-(N-benzoyl-N-methylamino)propiophenone through dynamic kinetic resolution was performed by using a polymer-immobilized chiral diamine-ruthenium-BINAP-t-BuOK system in order to yield syn-beta-amide alcohol exclusively with nearly perfect enantioselectivity.

  DOI：

  10.1021/jo802339t

文献信息

• Polymer-Immobilized Catalyst for Asymmetric Hydrogenation of Racemic α-(<i>N</i>-Benzoyl-<i>N</i>-methylamino)propiophenone
  作者：Vinia Ipai Chiwara、Naoki Haraguchi、Shinichi Itsuno

  DOI：10.1021/jo802339t

  日期：2009.2.6

  Asymmetric hydrogenation of alpha-(N-benzoyl-N-methylamino)propiophenone through dynamic kinetic resolution was performed by using a polymer-immobilized chiral diamine-ruthenium-BINAP-t-BuOK system in order to yield syn-beta-amide alcohol exclusively with nearly perfect enantioselectivity.