2-(4-chlorophenyl)-3-fluoro-1-methyl-1H-indole | 1570215-15-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-(4-chlorophenyl)-3-fluoro-1-methyl-1H-indole
• 英文别名: 2-(4-Chlorophenyl)-3-fluoro-1-methylindole；2-(4-chlorophenyl)-3-fluoro-1-methylindole
• CAS: 1570215-15-4
• 化学式: C₁₅H₁₁ClFN
• 分子量: 259.71
• InChiKey: ZSDZGMJIWDUKMS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  4.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-(4-氯苯基)-N-苯基甲亚胺 在 Ru(bpy)₃(BF₄)₂ 、 sodium acetate 、 三苯基膦 作用下， 以 乙腈 为溶剂， 反应 22.0h， 生成 2-(4-chlorophenyl)-3-fluoro-1-methyl-1H-indole
  参考文献：
  名称：

  Synthesis of 3-Fluoroindoles via Photoredox Catalysis

  摘要：

  A method for the synthesis of 3-fluoroindoles from N-arylamines substituted with the CF2I group is described. The reaction is mediated by a ruthenium photocatalyst in the presence of a substoichiometric amount of triphenylphosphine upon irradiation with blue light. The starting N-arylamines are readily obtained by nucleophilic iododifluoromethylation of iminium ions.

  DOI：

  10.1021/acs.joc.6b02344

文献信息

• Silver-catalyzed one-pot cyclization/fluorination of 2-alkynylanilines: highly efficient synthesis of structurally diverse fluorinated indole derivatives
  作者：Lei Yang、Yuanhong Ma、Feijie Song、Jingsong You

  DOI：10.1039/c3cc49851d

  日期：——

  Highly efficient approaches to obtain structurally diverse fluorinated indole derivatives have been realized through the Ag-catalyzed one-pot cyclization/fluorination of 2-alkynylanilines in the presence of NFSI or Selectfluor.

  在NFSI或Selectfluor的存在下，通过Ag催化的2-炔基苯胺的一锅环化/氟化，已经获得了获得结构多样的氟化吲哚衍生物的高效方法。
• Synthesis of 3-Fluoroindoles via Photoredox Catalysis
  作者：Liubov I. Panferova、Vladimir O. Smirnov、Vitalij V. Levin、Vladimir A. Kokorekin、Marina I. Struchkova、Alexander D. Dilman

  DOI：10.1021/acs.joc.6b02344

  日期：2017.1.6

  A method for the synthesis of 3-fluoroindoles from N-arylamines substituted with the CF2I group is described. The reaction is mediated by a ruthenium photocatalyst in the presence of a substoichiometric amount of triphenylphosphine upon irradiation with blue light. The starting N-arylamines are readily obtained by nucleophilic iododifluoromethylation of iminium ions.