Ethyl 2-[2-[2-[bis(2-ethoxy-2-oxoethyl)amino]ethyldisulfanyl]ethyl-(2-ethoxy-2-oxoethyl)amino]acetate | 958638-35-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Ethyl 2-[2-[2-[bis(2-ethoxy-2-oxoethyl)amino]ethyldisulfanyl]ethyl-(2-ethoxy-2-oxoethyl)amino]acetate
• 英文别名: ethyl 2-[2-[2-[bis(2-ethoxy-2-oxoethyl)amino]ethyldisulfanyl]ethyl-(2-ethoxy-2-oxoethyl)amino]acetate
• CAS: 958638-35-2
• 化学式: C₂₀H₃₆N₂O₈S₂
• 分子量: 496.646
• InChiKey: CGWOBBLRBBZJCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  32
• 可旋转键数：
  23
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  162
• 氢给体数：
  0
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  Ethyl 2-[2-[2-[bis(2-ethoxy-2-oxoethyl)amino]ethyldisulfanyl]ethyl-(2-ethoxy-2-oxoethyl)amino]acetate 在 sodium hydroxide 、 水 作用下， 以 甲醇 为溶剂， 反应 24.0h， 生成 (3,4-dithia-hexanediyldiimino)-tetra-acetic acid
  参考文献：
  名称：

  Dumbbell-like Au−Fe₃O₄ Nanoparticles for Target-Specific Platin Delivery

  摘要：

  Dumbbeil-like Au-Fe3O4 nanoparticles (NPs) were made and coupled with Herceptin and a platin complex. The ptatin-Au-Fe3O4-Herceptin NPs act as a target-specific nanocarriers for delivery of platin into Her2-positive breast cancer cells (Sk-Br3) with strong therapeutic effects. The conjugate has a half-maximal inhibitory concentration (IC50) toward Sk-Br3 cells of 1.76 mu g of Pt/mL, which is lower than that needed for cisplatin (3.5 mu g/mL). The work demonstrates that the dumbbell-like Au-Fe3O4 NPs are promising nanocarriers for highly sensitive diagnostic and therapeutic applications.

  DOI：

  10.1021/ja900790v
• 作为产物：
  描述：

  cystamine dihydrochioride 、 溴乙酸乙酯 在 三乙胺 、 potassium iodide 作用下， 以 丙酮 为溶剂， 反应 6.0h， 以80%的产率得到Ethyl 2-[2-[2-[bis(2-ethoxy-2-oxoethyl)amino]ethyldisulfanyl]ethyl-(2-ethoxy-2-oxoethyl)amino]acetate
  参考文献：
  名称：

  Dumbbell-like Au−Fe₃O₄ Nanoparticles for Target-Specific Platin Delivery

  摘要：

  Dumbbeil-like Au-Fe3O4 nanoparticles (NPs) were made and coupled with Herceptin and a platin complex. The ptatin-Au-Fe3O4-Herceptin NPs act as a target-specific nanocarriers for delivery of platin into Her2-positive breast cancer cells (Sk-Br3) with strong therapeutic effects. The conjugate has a half-maximal inhibitory concentration (IC50) toward Sk-Br3 cells of 1.76 mu g of Pt/mL, which is lower than that needed for cisplatin (3.5 mu g/mL). The work demonstrates that the dumbbell-like Au-Fe3O4 NPs are promising nanocarriers for highly sensitive diagnostic and therapeutic applications.

  DOI：

  10.1021/ja900790v

文献信息

• US7988858B2
  申请人：——

  公开号：US7988858B2

  公开（公告）日：2011-08-02
• Dumbbell-like Au−Fe₃O₄ Nanoparticles for Target-Specific Platin Delivery
  作者：Chenjie Xu、Baodui Wang、Shouheng Sun

  DOI：10.1021/ja900790v

  日期：2009.4.1

  Dumbbeil-like Au-Fe3O4 nanoparticles (NPs) were made and coupled with Herceptin and a platin complex. The ptatin-Au-Fe3O4-Herceptin NPs act as a target-specific nanocarriers for delivery of platin into Her2-positive breast cancer cells (Sk-Br3) with strong therapeutic effects. The conjugate has a half-maximal inhibitory concentration (IC50) toward Sk-Br3 cells of 1.76 mu g of Pt/mL, which is lower than that needed for cisplatin (3.5 mu g/mL). The work demonstrates that the dumbbell-like Au-Fe3O4 NPs are promising nanocarriers for highly sensitive diagnostic and therapeutic applications.