Fusarsaeure | 83282-13-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Fusarsaeure
• 英文别名: 6-butyl-pyridine-2-carboxylic acid；6-Butyl-pyridin-2-carbonsaeure；6-n-butyl-2-pyridinecarboxylic acid；6-butylpyridine-2-carboxylic acid
• CAS: 83282-13-7
• 化学式: C₁₀H₁₃NO₂
• 分子量: 179.219
• InChiKey: UOPAAWLTEKWBNC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Fusarsaeure 在 氯化亚砜 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 生成 N-(5-tetrazolyl)-6-n-butyl-2-pyridinecarboxamide
  参考文献：
  名称：

  Antiallergic agents. 3. N-(1H-tetrazol-5-yl)-2-pyridinecarboxamides

  摘要：

  A series of N-tetrazolylpyridinecarboxamides was prepared and evaluated for antiallergic activity by the passive cutaneous anaphylaxis (PCA) assay. From the structure-activity relationships (SAR) of this class of compounds, it was revealed that the N-tetrazolylcarbamoyl group as an acidic functionality is required to be at the 2-position of the pyridine nucleus and that the phenyl group as a subtituent is not necessarily required for activity. 6-Methyl-N-(1H-tetrazol-5-yl)-2-pyridinecarboxamide (36) showed good oral activity and low toxicity.

  DOI：

  10.1021/jm00368a005
• 作为产物：
  描述：

  2-but-1-en-ξ-yl-6-butyl-pyridine 在 potassium permanganate 、 丙酮 作用下， 生成 Fusarsaeure
  参考文献：
  名称：

  Nakashima, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1958, vol. 78, p. 661,665

  摘要：

  DOI：

文献信息

• Proteasome inhibitors and methods of using the same
  申请人：Bernardini Raffaella

  公开号：US20060189806A1

  公开（公告）日：2006-08-24

  The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly or indirectly with proteasome activity.

  本发明提供了硼酸化合物、硼酸酯及其组合物，可以调节细胞凋亡，例如通过抑制蛋白酶体活性。这些化合物和组合物可用于诱导细胞凋亡和治疗癌症等疾病，以及与蛋白酶体活性直接或间接相关的其他疾病。
• 2-Pyridinecarboxamide derivatives compositions containing same and
  申请人：Tanabe Seiyaku Co., Ltd.

  公开号：US04404214A1

  公开（公告）日：1983-09-13

  A 2-pyridinecarboxamide derivative of the formula: ##STR1## wherein R.sup.1 is hydrogen, lower alkyl, lower alkoxy, halogen, lower alkyl-thio or nitro and is in the 3rd-, 4th- or 5th-position of the pyridyl group, and R.sup.2 is hydrogen, lower alkyl, lower alkoxy, phenoxy, phenyl-lower alkyl, phenyl-lower alkenyl, or halogen. Said 2-pyridinecarboxamide derivative (I) or a pharmaceutically acceptable salt thereof is useful as an anti-allergic agent.

  该2-吡啶羧酰胺衍生物的化学式为：##STR1## 其中R.sup.1为氢、较低的烷基、较低的烷氧基、卤素、较低的烷基硫或硝基，并位于吡啶基的第3、第4或第5位置，而R.sup.2为氢、较低的烷基、较低的烷氧基、苯氧基、苯基-较低的烷基、苯基-较低的烯基或卤素。所述的2-吡啶羧酰胺衍生物(I)或其药用可接受的盐可用作抗过敏药物。
• 2-Pyridinecarboxamide derivative, process for preparing same and pharmaceutical composition, useful as an anti-allergic agent
  申请人：Tanabe Seiyaku Co., Ltd.

  公开号：EP0053789A1

  公开（公告）日：1982-06-16

  A 2-pyridinecarboxamide derivative of the formula: wherein R' is hydrogen, lower alkyl, lower alkoxy, halogen, lower alkyl-thio or nitro and is in the 3rd-, 4th- or 5th- position of the pyridyl group, and R2 is hydrogen, lower alkyl, lower alkoxy, phenoxy, phenyl-lower alkyl, phenyl-lower alkenyl, or halogen. Said 2-pyridinecarboxamide derivative (I) or a pharmaceutically acceptable salt thereof is useful as an anti-allergic agent.

  式中的 2-吡啶甲酰胺衍生物： 其中 R' 为氢、低级烷基、低级烷氧基、卤素、低级烷硫基或硝基，且位于吡啶基的第 3 位、第 4 位或第 5 位；R2 为氢、低级烷基、低级烷氧基、苯氧基、苯基-低级烷基、苯基-低级烯基或卤素。所述 2-吡啶甲酰胺衍生物（I）或其药学上可接受的盐可用作抗过敏剂。
• TAKEDA, MIKIO;HONMA, YASUSHI;TSUZURAHARA, KEI
  作者：TAKEDA, MIKIO、HONMA, YASUSHI、TSUZURAHARA, KEI

  DOI：——

  日期：——
• PROTEASOME INHIBITORS AND METHODS OF USING THE SAME
  申请人：CEPHALON, INC.

  公开号：EP1846424A1

  公开（公告）日：2007-10-24