2-aminoethyl 2-propylpentanoate hydrochloride | 1085446-37-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-aminoethyl 2-propylpentanoate hydrochloride
• 英文别名: 2-Aminoethyl 2-propylpentanoate hydrochloride；2-aminoethyl 2-propylpentanoate;hydrochloride
• CAS: 1085446-37-2
• 化学式: C₁₀H₂₁NO₂*ClH
• 分子量: 223.743
• InChiKey: LOVHCNZQRATOPZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.13
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  52.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-aminoethyl 2-propylpentanoate hydrochloride 、 [(3a,4aR,6R,6aR)-6-(4-amino-2-oxopyrimidin-1(2H)-yl)-2,2,6a-trimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]methyl phenyl phosphonate 在 三乙胺 作用下， 以 四氢呋喃 、 四氯化碳 、 异丙醇 为溶剂， 反应 0.5h， 生成 2-(((((3aR,4R,6R,6aR)-6-(4-amino-2-oxopyrimidin-1(2H)-yl)-2,2,6a-trimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methoxy)(phenoxy)phosphoryl)amino)ethyl 2-propylpentanoate
  参考文献：
  名称：

  丙型肝炎病毒NS5B聚合酶抑制剂2'-甲基胞苷新型氨基磷酸酯前药的合成与评价

  摘要：

  已经合成了多种基于酰氧基乙基氨基氨基磷酸酯的2'-甲基胞苷的新前药，并在体外和体内测试了它们的生物活性。与母体药物相比，大鼠和人肝细胞中三磷酸核苷酸的形成增加了 10 到 20 倍。

  DOI：

  10.1016/j.bmcl.2009.01.035

文献信息

• Antiviral Agents
  申请人：Attenni Barbara

  公开号：US20100152128A1

  公开（公告）日：2010-06-17

  A compound of formula (I) and pharmaceutically acceptable salts thereof; compositions containing it and its use in medicine, particularly for the treatment or inhibition of HCV infections, and processes for making it are disclosed.

  公式（I）的化合物及其药用盐；含有该化合物的组合物及其在医学上的用途，特别是用于治疗或抑制HCV感染，以及制备该化合物的方法。
• NUCLEOSIDE ARYL PHOSPHORAMIDATES FOR THE TREATMENT OF RNA-DEPENDENT RNA VIRAL INFECTION
  申请人：Narjes Frank

  公开号：US20100035835A1

  公开（公告）日：2010-02-11

  The present invention provides nucleoside aryl phosphoramidates of structural formula (I) which are precursors to inhibitors of RNA-dependent RNA viral polymerase. These compounds are precursors to inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as precursors to inhibitors of hepatitis C virus (HCV) NS5B polymerase, as precursors to inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside aryl phosphoramidates alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside aryl phosphoramidates of the present invention.

  本发明提供结构式（I）的核苷酸芳基磷酰胺衍生物，它们是RNA依赖性RNA病毒聚合酶抑制剂的前体。这些化合物是RNA依赖性RNA病毒复制抑制剂的前体，并且对于治疗RNA依赖性RNA病毒感染非常有用。它们特别适用于成为丙型肝炎病毒（HCV）NS5B聚合酶抑制剂的前体，成为HCV复制抑制剂的前体，和/或用于治疗丙型肝炎感染。本发明还描述了含有这种核苷酸芳基磷酰胺衍生物的药物组合物，单独或与其他针对RNA依赖性RNA病毒感染（特别是HCV感染）的活性剂合用。本发明还公开了使用本发明的核苷酸芳基磷酰胺衍生物抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。
• Phosphoramidate Prodrugs of 2′-<i>C</i>-Methylcytidine for Therapy of Hepatitis C Virus Infection
  作者：Cristina Gardelli、Barbara Attenni、Monica Donghi、Malte Meppen、Barbara Pacini、Steven Harper、Annalise Di Marco、Fabrizio Fiore、Claudio Giuliano、Vincenzo Pucci、Ralph Laufer、Nadia Gennari、Isabella Marcucci、Joseph F. Leone、David B. Olsen、Malcolm MacCoss、Michael Rowley、Frank Narjes

  DOI：10.1021/jm900447q

  日期：2009.9.10

  The application of a phosphoramidate prodrug approach to 2'-C-methylcytidine (NM107), the first nucleoside inhibitor of the hepatitis C virus (HCV) NS5B polymerase, is reported. 2'-C-Methylcytidine, as its valyl ester prodrug (NM283), was efficacious in reducing the viral load in patients infected with HCV. Several of the phosphoramidates prepared demonstrated a 10- to 200-fold superior potency with respect to the parent nucleoside in the cell-based replicon assay. This is due to higher levels of 2'-C-methylcytidine triphosphate in the cells. These prodrugs are efficiently activated and converted to the triphosphate in hepatocytes of several species. Our SAR studies ultimately led to compounds that gave high levels of NTP in hamster and rat liver after subcutaneous dosing and that were devoid of the toxic phenol moiety usually found in ProTides.
• ANTIVIRAL AGENTS
  申请人：Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A.

  公开号：EP2203463A2

  公开（公告）日：2010-07-07
• US8071568B2
  申请人：——

  公开号：US8071568B2

  公开（公告）日：2011-12-06