pyrido<2,3-d>pyridazine-5,8-dione | 91533-15-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: pyrido<2,3-d>pyridazine-5,8-dione
• 英文别名: 2,3,5-Triaza-1,4-naphthochinon；5-Aza-phthalazin-dion-1,4；pyrido[2,3-d]pyridazine-5,8-dione；Pyrido[2,3-d]pyridazine-5,8-dione
• CAS: 91533-15-2
• 化学式: C₇H₃N₃O₂
• 分子量: 161.12
• InChiKey: ZMTNWEPNFQMNAW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  71.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  pyrido<2,3-d>pyridazine-5,8-dione 在 双氧水 作用下， 以 丙酮 为溶剂， 以0.47 g的产率得到2,3-吡啶二甲酸
  参考文献：
  名称：

  Paul, D. Brenton, Australian Journal of Chemistry, 1984, vol. 37, # 5, p. 1001 - 1008

  摘要：

  DOI：

文献信息

• USE OF CYCLIC BIOISOSTERES OF PURINE SYSTEM DERIVATIVES FOR THE TREATMENT OF DISEASES CAUSED BY DISORDERS OF NITRERGIC AND DOPAMINERGIC SYSTEMS
  申请人：Zhilov, Valery Khazhmuratovich

  公开号：EP1655028A2

  公开（公告）日：2006-05-10

  The invention relates to application of compounds having a general structural formula: where R= Li, Na, K, R1 = -H, -NH2, -Br, -Cl, -OH, -COOH, B = -N=, -CH=, Z = -CH= , -N=, A = -N= at B = -N= , Z = -CH-, A=-CH= at B = -N= , Z=-CH-, A = -CH= at B = -N= , Z = -N=, A = -CH= at B = -CH= , Z = -CH=, A = -CH= at B = -CH= , Z = -N= , and/or their pharmacologically acceptable salts as an active ingredient having appropriate activity with respect to nitrergic and/or dopaminergic systems, in a pharmaceutical composition as neuroprotector for improvement of the cognitive function and for normalization of psychophysiological status, as well as for treatment of a wide spectrum of psychological diseases, cardiovascular diseases, diseases caused by substance abuse, and diseases caused by a hyperactive immune system in mammals including human beings.

  本发明涉及具有一般结构式的化合物的应用： 其中 R= Li、Na、K R1 = -H、-NH2、-Br、-Cl、-OH、-COOH、 B = -N=，-CH=，Z = -CH= ，-N=、 A=-N=，B=-N=，Z=-CH-、 A=-CH= at B = -N= , Z=-CH-、 A = -CH= at B = -N= , Z = -N=、 A = -CH= at B = -CH= , Z = -CH=、 A = -CH= at B = -CH= , Z = -N= 、 和/或它们的药理学上可接受的盐类作为活性成分，在硝酸能和/或多巴胺能系统方面具有适当的活性，在药物组合物中作为神经保护剂，用于改善认知功能，使心理生理状态正常化，以及治疗包括人类在内的哺乳动物的各种心理疾病、心血管疾病、药物滥用引起的疾病和免疫系统过度活跃引起的疾病。
• CYCLIC BIOISOSTERS OF PURINE SYSTEM DERIVATIVES AND A PHARMACEUTICAL COMPOSITION BASED THEREON
  申请人：Zhilov, Valery Khazhmuratovich

  公开号：EP1655301A1

  公开（公告）日：2006-05-10

  The invention relates to cyclic bioisosteres of derivatives of a purine system having a general structural formula R1 = -H, -NH2, -Br, -C1, -OH, -COOH, B = -N=, -CH=, Z = -CH=, -N=, A = -N= at B = -N=, Z = -CH-, A = -CH= at B = -N=, Z = -CH-, A = -CH= at B = -N=, Z = -N=, A = -CH= at B = -CH=, Z = -CH=, A = -CH= at B = -CH=, Z = -N= , and their pharmacologically acceptable salts having a normalizing effect on endocellular processes, in particular, it is capable eliminating endocellular metabolic acidosis and capable of binding excessively formed free radicals, in particular, free-radical forms of oxygen, capable of normalizing the nitrergic mechanisms of the cells, and also capable of interreacting with adenosine-sensitive receptors on the membrane of non-nuclear cells and in nuclei-containing cells to decrease the aggregation of thrombocytes. The compounds according to the invention have hepatoprotective effect and can be used for producing pharmaceutical compositions on their base.

  本发明涉及嘌呤系统衍生物的环状生物异斯特，其结构通式为 R1 = -H, -NH2, -Br, -C1, -OH, -COOH、 B = -N=，-CH=，Z = -CH=，-N=、 A = -N= at B = -N=, Z = -CH-、 A = -CH= at B = -N=, Z = -CH-、 A = -CH= at B = -N=, Z = -N=、 A = -CH= at B = -CH=，Z = -CH=、 A = -CH= at B = -CH=, Z = -N= 、 及其药理上可接受的盐类，对细胞内过程具有正常化作用，特别是能消除细胞内代谢性酸中毒，能结合过多形成的自由基，特别是氧的自由基形式，能使细胞的硝化机制正常化，还能与无核细胞膜上和含核细胞膜上的腺苷敏感受体相互作用，减少血小板的聚集。本发明的化合物具有保肝作用，可用于生产以其为基础的药物组合物。
• Use of cyclic bioisosteres of purine system derivatives for the treatment of diseases caused by disorders of nitrergic and dopaminergic systems
  申请人：Zhilov, Valery Khazhmuratovich

  公开号：EP2074998A2

  公开（公告）日：2009-07-01

  The invention relates to application of compounds having a general structural formula: Li, Na, K, R1= -H, -NH2, -Br, -Cl, -OH, -COOH, B = -N=, -CH=, Z = -CH=, -N=, A = -N= at B = -N=, Z = -CH-, A = -CH= at B = -N=, Z = -CH-, A = -CH= at B = -N=, Z = -N=, A = -CH= at B -CH=, Z = -CH=, A = -CH= at B = -CH=, Z = -N= , and/or their pharmacologically acceptable salts as an active ingredient having appropriate activity with respect to nitrergic and/or dopaminergic systems, in a pharmaceutical composition as a neuroprotector for the improvement of the cognitive function and for normalization of the psychophysiological status, as well as for the treatment of a wide spectrum of psychological diseases, cardiovascular diseases, diseases caused by substance abuse, and diseases caused by a hyperactive immune system in mammals including human beings.

  本发明涉及具有一般结构式的化合物的应用： Li、Na、K、 R1=-H、-NH2、-Br、-Cl、-OH、-COOH、 B = -N=，-CH=，Z = -CH=，-N=、 A = -N= at B = -N=, Z = -CH-、 A = -CH= at B = -N=, Z = -CH-、 A = -CH= at B = -N=, Z = -N=、 A = -CH= at B -CH=, Z = -CH=、 A = -CH= at B = -CH=, Z = -N= 、 和/或它们的药理上可接受的盐类作为活性成分，在硝酸能和/或多巴胺能系统方面具有适当的活性，在药物组合物中作为神经保护剂，用于改善认知功能，使心理生理状态正常化，以及治疗包括人类在内的哺乳动物的各种心理疾病、心血管疾病、药物滥用引起的疾病和免疫系统亢进引起的疾病。
• Use of cyclic bioisosters of purine system derivatives for treating diseases produced by disorders of niterergic and dopaminergic systems
  申请人：Zhilov Khazhmuratovich Valery

  公开号：US20070135636A1

  公开（公告）日：2007-06-14

  The invention relates to application of compounds having a general structural formula: where R═ Li, Na, K, R 1 =—H, —NH 2 , —Br, —Cl, —OH, —COOH, B=—N═, —CH═, Z=—CH═, —N═, A=—N═ at B=—N═, Z=—CH—, A=—CH═ at B=—N═, Z=—CH—, A=—CH═ at B=—N═, Z=—N═, A=—CH═ at B=—CH═, Z=—CH═, A=—CH═ at B=—CH═, Z=—N═, and/or their pharmacologically acceptable salts as an active ingredient having appropriate activity with respect to nitrergic and/or dopaminergic systems, in a pharmaceutical composition as neuroprotector for improvement of the cognitive function and for normalization of psychophysiological status, as well as for treatment of a wide spectrum of psychological diseases, cardiovascular diseases, diseases caused by substance abuse, and diseases caused by a hyperactive immune system in mammals including human beings.
• Use of a layer consisting of hydrophobic linear, or two-dimensional polycyclic aromatics as a barrier layer or an encapsulation and electric components constructed with a layer of this type and comprising organic polymers
  申请人：Dobbertin Thomas

  公开号：US20070166547A1

  公开（公告）日：2007-07-19

  The invention relates to cyclic bioisosteres of derivatives of a purine system having a general structural formula R 1 =—H, —NH 2 , —Br, —Cl, —OH, —COOH, B=—N═, —CH═, Z=—CH═, —N═, A=—N═ at B=—N═, Z=—CH—, A=—CH═ at B=—N═, Z=—CH—, A=—CH═ at B=—N═, Z=—N═, A=—CH═ at B=—CH═, Z=—CH═, A=—CH═ at B=—CH═, Z=—N═, and their pharmacologically acceptable salts having a normalizing effect on endocellular processes, in particular, it is capable eliminating endocellular metabolic acidosis and capable of binding excessively formed free radicals, in particular, free-radical forms of oxygen, capable of normalizing the nitrergic mechanisms of the cells, and also capable of interreacting with adenosine-sensitive receptors on the membrane of non-nuclear cells and in nuclei-containing cells to decrease the aggregation of thrombocytes. The compounds according to the invention have hepatoprotective effect and can be used for producing pharmaceutical compositions on their base.