[Cystamine]; Gen=0; dendri-PAMAM; (acetamide)4 | 893412-21-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [Cystamine]; Gen=0; dendri-PAMAM; (acetamide)4
• 英文别名: N-(2-acetamidoethyl)-3-[[3-(2-acetamidoethylamino)-3-oxopropyl]-[2-[2-[bis[3-(2-acetamidoethylamino)-3-oxopropyl]amino]ethyldisulfanyl]ethyl]amino]propanamide
• CAS: 893412-21-0
• 化学式: C₃₂H₆₀N₁₀O₈S₂
• 分子量: 777.023
• InChiKey: PQHHMJICPDZYGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.8
• 重原子数：
  52
• 可旋转键数：
  31
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  290
• 氢给体数：
  8
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  [Cystamine]; Gen=0; dendri-PAMAM; (acetamide)4 在 甲醇 、 二硫代脲 作用下， 反应 48.0h， 生成 C₁₆H₃₁N₅O₄S
  参考文献：
  名称：

  [EN] DELIVERY OF BIOLOGICALLY ACTIVE MATERIALS USING CORE-SHELL TECTO (DENDRITIC POLYMERS)
  [FR] ADMINISTRATION DE MATÉRIAUX BIOLOGIQUEMENT ACTIFS AU MOYEN DE "TECTO" (POLYMÈRES DENDRITIQUES) NOYAU-ENVELOPPE

  摘要：

  公开号：

  WO2008054466A3
• 作为产物：
  描述：

  乙酸酐 、 poly(amidoamine) 在 三乙胺 作用下， 以 甲醇 为溶剂， 生成 [Cystamine]; Gen=0; dendri-PAMAM; (acetamide)4
  参考文献：
  名称：

  [EN] DELIVERY OF BIOLOGICALLY ACTIVE MATERIALS USING CORE-SHELL TECTO (DENDRITIC POLYMERS)
  [FR] ADMINISTRATION DE MATÉRIAUX BIOLOGIQUEMENT ACTIFS AU MOYEN DE "TECTO" (POLYMÈRES DENDRITIQUES) NOYAU-ENVELOPPE

  摘要：

  公开号：

  WO2008054466A3

文献信息

• [EN] DENDRITIC POLYMERS WITH ENHANCED AMPLIFICATION AND INTERIOR FUNCTIONALITY<br/>[FR] POLYMERES DENDRITIQUES AVEC FONCTIONNALITE INTERIEURE ET AMPLIFICATION RENFORCEES
  申请人：DENDRITIC NANOTECHNOLOGIES INC

  公开号：WO2006115547A3

  公开（公告）日：2009-06-04
• Dendritic Polymers with Enhanced Amplification and Interior Functionality
  申请人：Tomalia A. Donald

  公开号：US20070244296A1

  公开（公告）日：2007-10-18

  Poly(ester-acrylate) and poly(ester/epoxide) dendrimers. These materials can be synthesized by utilizing the so-called “sterically induced stoichiometric” principles. The preparation of the dendrimers is carried out by reacting precursor amino/polyamino-functional core materials with various branch cell reagents. The branch cell reagents are dimensionally large, relative to the amino/polyamino-initiator core and when reacted, produce generation=1 dendrimers directly in one step. There is also a method by which the dendrimers can be stabilized and that method is the reaction of the dendrimers with surface reactive molecules to pacify the reactive groups on the dendrimers.
• Dendritic Polymers With Enhanced Amplification and Interior Functionality
  申请人：Tomalia A. Donald

  公开号：US20070298006A1

  公开（公告）日：2007-12-27

  Dendritic polymers with enhanced amplification and interior functionality are disclosed. These dendritic polymers are made by use of fast, reactive ring-opening chemistry (or other fast reactions) combined with the use of branch cell reagents in a controlled way to rapidly and precisely build dendritic structures, generation by generation, with cleaner chemistry, often single products, lower excesses of reagents, lower levels of dilution, higher capacity method, more easily scaled to commercial dimensions, new ranges of materials, and lower cost. The dendritic compositions prepared have novel internal functionality, greater stability (e.g., thermal stability and less or no reverse Michael's reaction), and reach encapsulation surface densities at lower generations. Unexpectedly, these reactions of polyfunctional branch cell reagents with polyfunctional cores do not create cross-linked materials. Such dendritic polymers are useful as demulsifiers for oil/water emulsions, wet strength agents in the manufacture of paper, proton scavengers, polymers, nanoscale monomers, calibration standards for electron microscopy, making size selective membranes, and agents for modifying viscosity in aqueous formulations such as paint. When these dendritic polymers have a carried material associated with their surface and/or interior, then these dendritic polymers have additional properties for carrying materials due to the unique characteristics of the dendritic polymer, such as for drug delivery, transfection, and diagnostics.
• Delivery of Biologically Active Materials Using Core-Shell Tecto(Dendritic Polymers)
  申请人：DeMattei Cordell R.

  公开号：US20090012033A1

  公开（公告）日：2009-01-08

  The present invention concerns core-shell tecto (dendritic polymers) that are associated with biologically active materials (such as nucleic acids for use for RNAi and in transfection). Also included are formulations for their use. The constructs are useful for the delivery of drugs to an animal or plant and may be in vivo, in vitro or ex vivo.
• US7985424B2
  申请人：——

  公开号：US7985424B2

  公开（公告）日：2011-07-26