dimethyl 4,5-bis(acetoxymethyl)phthalate | 881030-96-2

• 分子结构分类: 有机化合物
• 英文名称: dimethyl 4,5-bis(acetoxymethyl)phthalate
• CAS: 881030-96-2
• 化学式: C₁₆H₁₈O₈
• 分子量: 338.314
• InChiKey: KAYOPHGPDJWLPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.39
• 重原子数：
  24.0
• 可旋转键数：
  6.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  105.2
• 氢给体数：
  0.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  dimethyl 4,5-bis(acetoxymethyl)phthalate 在 氢溴酸 、 溶剂黄146 作用下， 以 二氯甲烷 为溶剂， 以46%的产率得到dimethyl 4,5-bis(bromomethyl)phthalate
  参考文献：
  名称：

  Design and Synthesis of Benzosultine-sulfone as a o-Xylylene Precursor via Cross-enyne Metathesis and Rongalite: Further Expansion to Polycyclics via Regioselective Diels−Alder Reaction

  摘要：

  Benzosultine-sulfone 5 has been prepared as a o-xylylene or o-quinodimethane precursor by utilization of rongalite. Thermal activation of this hybrid molecule 5 has resulted a new sulfone-based building block 6. Building block 5 is a suitable precursor for the synthesis of unsymmetrically functionalized polycyclics through Diels-Alder (DA) chemistry. The dibromosulfone 24 and benzosultine-sulfone 5 has also been used for the synthesis of various sulfone based unnatural a-amino acid (AAA) derivatives.

  DOI：

  10.1021/jo100655c
• 作为产物：
  描述：

  在 manganese(IV) oxide 作用下， 以 1,4-二氧六环 为溶剂， 反应 72.0h， 以1.08 g的产率得到dimethyl 4,5-bis(acetoxymethyl)phthalate
  参考文献：
  名称：

  Design and Synthesis of Benzosultine-sulfone as a o-Xylylene Precursor via Cross-enyne Metathesis and Rongalite: Further Expansion to Polycyclics via Regioselective Diels−Alder Reaction

  摘要：

  Benzosultine-sulfone 5 has been prepared as a o-xylylene or o-quinodimethane precursor by utilization of rongalite. Thermal activation of this hybrid molecule 5 has resulted a new sulfone-based building block 6. Building block 5 is a suitable precursor for the synthesis of unsymmetrically functionalized polycyclics through Diels-Alder (DA) chemistry. The dibromosulfone 24 and benzosultine-sulfone 5 has also been used for the synthesis of various sulfone based unnatural a-amino acid (AAA) derivatives.

  DOI：

  10.1021/jo100655c

文献信息

• One stone two birds: construction of polysubstituted benzenes from the same starting material and precatalyst by switching the active sites of catalyst with different additives
  作者：Chun Feng、Xin Wang、Bi-Qin Wang、Ke-Qing Zhao、Ping Hu、Zhang-Jie Shi

  DOI：10.1039/c1cc15835j

  日期：——

  Two different tetrasubstituted benzenes were selectively constructed from the same starting materials by tuning the active sites of the Grubbs second generation catalyst (GC-II) with CuI or AgOTf as the additive.

  两种不同的四取代苯类化合物是通过调节Grubbs第二代催化剂（GC-II）的活性位点，分别使用CuI或AgOTf作为添加剂，从相同的起始材料中选择性合成的。
• A Short Synthetic Route to a Hybrid Molecule Benzosultine-Sulfone via [2+2+2] Cyclotrimerization Using Mo(CO)6
  作者：Sambasivarao Kotha、Gaddamedi Sreevani

  DOI：10.3987/com-16-s(s)71

  日期：——

  Here, we report an improved and short synthetic route to benzosultine-sulfone via [2+2+2] cyclotrimerization as a key step, starting with dipropargyl ether and 1,4-dibromo-2-butyne with an overall yield of 16%.