7-bromo-1-[(R)-phenyl-(2-phenyl-1H-indol-3-yl)methyl]naphthalen-2-ol | 1443383-19-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 7-bromo-1-[(R)-phenyl-(2-phenyl-1H-indol-3-yl)methyl]naphthalen-2-ol
• CAS: 1443383-19-4
• 化学式: C₃₁H₂₂BrNO
• 分子量: 504.426
• InChiKey: VVSPRMKYNWFKSK-NDEPHWFRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.7
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  36
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-phenyl-3-[phenyl(tosyl)methyl]-1H-indole 、 2-溴-7-羟基萘 在 potassium phosphate 、 1-(3,5-bis(trifluoromethyl)phenyl)-3-((1S)-(6-methoxyquinolin-4-yl)(5-vinylquinuclidin-2-yl)methyl)thiourea 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以95%的产率得到7-bromo-1-[(R)-phenyl-(2-phenyl-1H-indol-3-yl)methyl]naphthalen-2-ol
  参考文献：
  名称：

  Organocatalytic asymmetric Michael addition of 2-naphthols to alkylideneindolenines generated in situ from arenesulfonylalkylindoles

  摘要：

  An efficient enantioselective Michael addition of 2-naphthols to alkylideneindolenines generated in situ from arenesulfonylalkylindoles has been described. The protocol provides an efficient and convenient access to C-3 alkyl-substituted indole derivatives containing phenolic hydroxyl groups with high yields (up to 96%) and enantioselectivities (up to 98% ee) under mild conditions. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.05.011

文献信息

• Organocatalytic asymmetric Michael addition of 2-naphthols to alkylideneindolenines generated in situ from arenesulfonylalkylindoles
  作者：Liangliang Yu、Xiaohua Xie、Song Wu、Rongming Wang、Wujun He、Dabin Qin、Quanzhong Liu、Linhai Jing

  DOI：10.1016/j.tetlet.2013.05.011

  日期：2013.7

  An efficient enantioselective Michael addition of 2-naphthols to alkylideneindolenines generated in situ from arenesulfonylalkylindoles has been described. The protocol provides an efficient and convenient access to C-3 alkyl-substituted indole derivatives containing phenolic hydroxyl groups with high yields (up to 96%) and enantioselectivities (up to 98% ee) under mild conditions. (C) 2013 Elsevier Ltd. All rights reserved.