1-Hydroxy-8-acetyl-9,10-anthrachinon | 63972-52-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 1-Hydroxy-8-acetyl-9,10-anthrachinon
• 英文别名: 1-Acetyl-8-hydroxyanthracene-9,10-dione
• CAS: 63972-52-1
• 化学式: C₁₆H₁₀O₄
• 分子量: 266.253
• InChiKey: IUULFEHHNLFGDT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  71.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-Hydroxy-8-acetyl-9,10-anthrachinon 在 sodium sulfide 、 硫酸 、 硝酸 作用下， 生成 5-Acetylchinizarin
  参考文献：
  名称：

  嗜热链球菌WR-141的萘醌和蒽醌。结构和模型综合

  摘要：

  除了先前确定的抗生素Granaticin 1外，热链霉菌WR-141还显示产生二氢Granaticin 2和蒽醌色素5和6。描述了这些抗生素颜料的生色团和二氢吡喃部分的模型合成。

  DOI：

  10.1016/0040-4020(77)80309-8
• 作为产物：
  描述：

  5-acetyl-1,4-naphthoquinone 在 氢溴酸 、 溶剂黄146 、 silver(l) oxide 作用下， 以 xylene 为溶剂， 生成 1-Hydroxy-8-acetyl-9,10-anthrachinon
  参考文献：
  名称：

  嗜热链球菌WR-141的萘醌和蒽醌。结构和模型综合

  摘要：

  除了先前确定的抗生素Granaticin 1外，热链霉菌WR-141还显示产生二氢Granaticin 2和蒽醌色素5和6。描述了这些抗生素颜料的生色团和二氢吡喃部分的模型合成。

  DOI：

  10.1016/0040-4020(77)80309-8

文献信息

• Design, synthesis, and studies of small molecule STAT3 inhibitors
  作者：Deepak Bhasin、Katryna Cisek、Trupti Pandharkar、Nicholas Regan、Chenglong Li、Bulbul Pandit、Jiayuh Lin、Pui-Kai Li

  DOI：10.1016/j.bmcl.2007.10.031

  日期：2008.1

  A series of small molecule STAT3 inhibitors originally derived from our lead compound STA 21 were synthesized and evaluated. The most potent compound in this series, compound 1, exhibited the same anti-proliferative activities as STA 21 against prostate cancer cell lines that express constitutively active STAT3. Molecular docking showed compound 1 bound to the STAT3 beta SH2 domain in a similar manner as STA 21. (C) 2007 Elsevier Ltd. All rights reserved.
• STAT3 INHIBITING COMPOSITIONS AND METHODS
  申请人：Farjo Rafal A.

  公开号：US20110077306A1

  公开（公告）日：2011-03-31

  STA-21-related compounds, for example CLT-005, are shown to prevent dimerization of STAT3, thereby inhibiting STAT3 activity. Inhibition of STAT3 activity is shown to reduce intraocular inflammation and neovascularization, symptoms of eye-related diseases such as age-related macular degeneration. Inhibition of STAT3 prevents STAT3 from transcriptionally activating downstream gene targets that are known to be associated with retinal inflammation and neovascularization and such disorders as age-related macular degeneration.
• 1-ACETYL-5-HYDROXYANTHRACENE-9,10-DIONE FOR TREATMENT OF RETINAL DISEASE
  申请人：Farjo Rafal A.

  公开号：US20120059067A1

  公开（公告）日：2012-03-08

  A composition may include a pharmaceutical carrier and an amount, therapeutically effective for the treatment of a retinal disease, of CLT-005 (1-acetyl-5-hydroxyanthracene-9,10-dione), wherein the retinal disease is characterized by at least one of inflammation, angiogenesis, or neovascularization, and wherein the composition is prepared for administration topically. The composition may be administered topically to a subject's eye.
• US8058316B2
  申请人：——

  公开号：US8058316B2

  公开（公告）日：2011-11-15