[(4S,6R,7S)-4,8-Bis-(tert-butyl-dimethyl-silanyloxy)-6-(4-methoxy-benzyloxy)-6,7-dimethyl-2-oxo-octyl]-phosphonic acid dimethyl ester | 224579-97-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(4S,6R,7S)-4,8-Bis-(tert-butyl-dimethyl-silanyloxy)-6-(4-methoxy-benzyloxy)-6,7-dimethyl-2-oxo-octyl]-phosphonic acid dimethyl ester
• CAS: 224579-97-9
• 化学式: C₃₂H₆₁O₈PSi₂
• 分子量: 660.976
• InChiKey: CSRCYGNSFKCJLG-IUGUYLHOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.85
• 重原子数：
  43.0
• 可旋转键数：
  18.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  89.52
• 氢给体数：
  0.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  [(4S,6R,7S)-4,8-Bis-(tert-butyl-dimethyl-silanyloxy)-6-(4-methoxy-benzyloxy)-6,7-dimethyl-2-oxo-octyl]-phosphonic acid dimethyl ester 在 2,6-二甲基吡啶 、 potassium osmate(VI) 、 AD-mix-α 、 氢氟酸 、 碳酸氢钠 、 氢化奎宁 1,4-(2,3-二氮杂萘)二醚 、 N,N-二异丙基乙胺 、 lithium chloride 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 反应 77.0h， 生成 (2S,3R,5S,8R,9S,10R,12S)-5,8,9-Tris-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-3-(4-methoxy-benzyloxy)-2,3,10-trimethyl-12-triisopropylsilanyloxy-tridecan-7-one
  参考文献：
  名称：

  2. Synthesis of the C.14–C.26 hydrophilic domain of amphidinolide B1 and formation of the (E)-1,1′,3-trisubstituted diene sector

  摘要：

  In the preceding letter, we described a synthesis of the conserved C.1-C.13 hydrophobic domain common to the potent B-type amphidinolides. In this letter, we present syntheses of the C.14-C.26 hydrophilic domain specific to amphidinolide B1 and a model for uniting the hydrophobic and hydrophilic domains to form the (E)-1,1',3-trisubstituted diene. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00207-5
• 作为产物：
  描述：

  [(4R,6R,7S)-4,8-Bis-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-6-(4-methoxy-benzyloxy)-6,7-dimethyl-octyl]-phosphonic acid dimethyl ester 在 N-甲基吲哚酮 、 四丙基高钌酸铵 作用下， 生成 [(4S,6R,7S)-4,8-Bis-(tert-butyl-dimethyl-silanyloxy)-6-(4-methoxy-benzyloxy)-6,7-dimethyl-2-oxo-octyl]-phosphonic acid dimethyl ester
  参考文献：
  名称：

  2. Synthesis of the C.14–C.26 hydrophilic domain of amphidinolide B1 and formation of the (E)-1,1′,3-trisubstituted diene sector

  摘要：

  In the preceding letter, we described a synthesis of the conserved C.1-C.13 hydrophobic domain common to the potent B-type amphidinolides. In this letter, we present syntheses of the C.14-C.26 hydrophilic domain specific to amphidinolide B1 and a model for uniting the hydrophobic and hydrophilic domains to form the (E)-1,1',3-trisubstituted diene. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00207-5