N,N'-bis[2-(acetyloxy)-1-[(acetyloxy)methyl]ethyl]-malonamide | 479487-37-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N'-bis[2-(acetyloxy)-1-[(acetyloxy)methyl]ethyl]-malonamide
• 英文别名: [3-Acetyloxy-2-[[3-(1,3-diacetyloxypropan-2-ylamino)-3-oxopropanoyl]amino]propyl] acetate
• CAS: 479487-37-1
• 化学式: C₁₇H₂₆N₂O₁₀
• 分子量: 418.401
• InChiKey: WYCGOHMPXQJTSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  29
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  163
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  N,N'-bis[2-(acetyloxy)-1-[(acetyloxy)methyl]ethyl]-malonamide 在 溴 、 三乙胺 作用下， 以 乙酸乙酯 为溶剂， 以79%的产率得到2-bromo-N,N'-bis[2-(acetyloxy)-1-[(acetyloxy)methyl]ethyl]-malonamide
  参考文献：
  名称：

  专为生物相容性而设计的新型非离子，高度水溶性的C 60衍生物

  摘要：

  迄今为止最水溶性（> 240 mg C 60 mL -1）的富勒烯衍生物，新的丙二醛二叠氮化酰胺富勒烯C 60 [C（COSer）2 ] n（n = 4，5，6，Ser = 2-amino-1 ，3-丙二醇），已经合成并表征。这些化合物旨在提供最大的水溶性和生物相容性。简便的合成是基于Bingel对C 60的添加，应适用于任何潜在的基于富勒烯的药物的增溶。

  DOI：

  10.1016/s0040-4039(01)00956-x
• 作为产物：
  描述：

  乙酸酐 、 N,N'-Bis-(2-hydroxy-1-hydroxymethyl-ethyl)-malonamide 在 吡啶 作用下， 生成 N,N'-bis[2-(acetyloxy)-1-[(acetyloxy)methyl]ethyl]-malonamide
  参考文献：
  名称：

  专为生物相容性而设计的新型非离子，高度水溶性的C 60衍生物

  摘要：

  迄今为止最水溶性（> 240 mg C 60 mL -1）的富勒烯衍生物，新的丙二醛二叠氮化酰胺富勒烯C 60 [C（COSer）2 ] n（n = 4，5，6，Ser = 2-amino-1 ，3-丙二醇），已经合成并表征。这些化合物旨在提供最大的水溶性和生物相容性。简便的合成是基于Bingel对C 60的添加，应适用于任何潜在的基于富勒烯的药物的增溶。

  DOI：

  10.1016/s0040-4039(01)00956-x

文献信息

• Targeted Nanostructures for Cellular Imaging
  申请人：Wilson Lon J.

  公开号：US20090214101A1

  公开（公告）日：2009-08-27

  Compositions and methods related to targeted carbon nanostructures. More particularly, targeted carbon nanostructures comprising: a C n , a cross-linker, and a targeting agent, wherein C n refers to a fullerene moiety or nanotube comprising n carbon atoms. One example of a method may involve a method for imaging comprising: contacting a targeted carbon nanostructure and a cell; allowing the cell to internalize the carbon nanostructure; and detecting the presence of internalized carbon nanostructures.

  与靶向碳纳米结构相关的组合物和方法。更具体地，所述靶向碳纳米结构包括：一个Cn，一个交联剂和一个靶向试剂，其中Cn指的是包含n个碳原子的富勒烯基团或纳米管。一个方法的一个示例可能涉及一种成像方法，包括：接触靶向碳纳米结构和一个细胞；使细胞内化碳纳米结构；并检测内化的碳纳米结构的存在。
• Photosensitizers for Targeted Photodynamic Therapy
  申请人：Wharton Tim

  公开号：US20090076115A1

  公开（公告）日：2009-03-19

  The present invention relates to photosensitizer compounds based on functionalized fullerenes useful in targeted photodynamic therapy (PDT), and methods of use thereof.

  本发明涉及基于功能化富勒烯的光敏剂化合物，用于靶向光动力疗法（PDT）以及其使用方法。
• Highly-Iodinated Fullerene as a Contrast Agent For X-ray Imaging
  作者：Tim Wharton、Lon J. Wilson

  DOI：10.1016/s0968-0896(02)00252-3

  日期：2002.11

  The first fullerene-based X-ray contrast agent (CA) has been designed, synthesized, and characterized. The new CA is an externally functionalized derivative Of C-60 that is conceptually based on contemporary X-ray CA, all of which use iodine as the X-ray attenuating vehicle and are based on the 2,4,6-triiodinated-benzene-ring substructure. Using a modified Bingel-type reaction, a single addend containing 6 iodine atoms and 8 protected hydroxyl groups was appended to C-60 followed by the addition of 4 more addends each containing 4 protected hydroxyl groups. Final deprotection afforded the highly water-soluble (>460 mg/mL), non-ionic, highly-iodinated (24% I) fullerene for application as an X-ray contrast agent. (C) 2002 Elsevier Science Ltd. All rights reserved.
• PHOTOSENSITIZERS FOR TARGETED PHOTODYNAMIC THERAPY
  申请人：Wharton John Timothy

  公开号：US20100184818A1

  公开（公告）日：2010-07-22

  The present invention provides photosensitizer compounds based on functionalized fullerenes useful in targeted photodynamic therapy (PDT), and methods of use thereof.
• FULLERENE COMPOSITIONS AND METHODS FOR PHOTOCHEMICAL PURIFICATION
  申请人：Alvarez Pedro J.J.

  公开号：US20120189492A1

  公开（公告）日：2012-07-26

  In various embodiments, the present disclosure describes fullerene derivatives that are capable of photocatalytically generating reactive oxygen species in the presence of ultraviolet and/or visible light. In some embodiments, the fullerene derivatives are aminofullerenes containing a plurality of amine-terminated moieties covalently bonded to the fullerene cage. The fullerene derivatives may optionally be covalently bonded to a substrate surface for use in photocatalytic disinfection systems for removing various contaminants including, for example, bacteria, viruses, protozoa and chemical pollutants. Methods using the present fullerene and aminofullerene derivatives in various purification processes are also described herein.