diphenyl-(4-pyridyl)methyl methacrylate | 85328-09-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diphenyl-(4-pyridyl)methyl methacrylate
• 英文别名: [diphenyl(pyridin-4-yl)methyl] 2-methylprop-2-enoate
• CAS: 85328-09-2
• 化学式: C₂₂H₁₉NO₂
• 分子量: 329.398
• InChiKey: KAUZNOILQDCJIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  二苯基(4-吡啶基)甲醇 、 甲基丙烯酰氯 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 20.0h， 以35.5%的产率得到diphenyl-(4-pyridyl)methyl methacrylate
  参考文献：
  名称：

  Two new polymorphs of diphenyl(4-pyridyl)methyl methacrylate

  摘要：

  The title compound (D4PyMA), C22H19NO2, exhibits polymorphism after crystallization by slow evaporation from a binary mixture of chloroform and hexane. Long needle-like crystals have an orthorhombic structure (space group Fdd2), with one molecule in the asymmetric unit, while small tablet-like crystals exhibit a monoclinic crystal structure (space group P2(1)/n), in which two independent but chemically identical molecules comprise the asymmetric unit. The bond lengths and angles are normal, while the torsion angles around the -C-O- bond linking the diphenyl(4-pyridyl)methyl and methacrylate groups show the flexibility of the molecule by way of packing effects. The two polymorphs both contain weak C-H...pi and C-H...O/N contacts but have different conformations.

  DOI：

  10.1107/s0108270104024217

文献信息

• Optically active polymers of methacrylate esters
  申请人：DAICEL CHEMICAL INDUSTRIES, LTD.

  公开号：EP0068290A1

  公开（公告）日：1983-01-05

  A new organic polymer useful for the optical resolution or solvent fractionation is provided. The organic polymer is a homopolymer or copolymer comprising mainly a specific methacrylate ester constitutional unit and having (+) or (-) optical rotation and, therefore, an optical activity.

  本研究提供了一种可用于光学解析或溶剂分馏的新型有机聚合物，这种有机聚合物是一种均聚物或共聚物，主要由特定的甲基丙烯酸酯组成，具有（+）或（-）旋光性，因此具有光学活性。
• Polymerizable, optically active polymer and process for preparing polymerizable polymer
  申请人：DAICEL CHEMICAL INDUSTRIES, LTD.

  公开号：EP0095086A1

  公开（公告）日：1983-11-30

  A polymerizable polymer is obtained by the anionic polymerization and termination by use of a vinyl monomer. It produces a graft copolymer by co-polymerization with another monomer. The process produces a new, polymerizable, optically active polymer and a graft copolymer thereof.

  一种可聚合聚合物是通过阴离子聚合并使用乙烯基单体终止而得到的。它通过与另一种单体共聚产生接枝共聚物。该工艺可生产出一种新的、可聚合的光学活性聚合物及其接枝共聚物。
• Responsive microgel and methods related thereto
  申请人：——

  公开号：US20030152623A1

  公开（公告）日：2003-08-14

  A responsive microgel is provided which responds volumetrically and reversibly to a change in one or more aqueous conditions selected from the group consisting of (temperature, pH, and ionic conditions) comprised of an ionizable network of covalently cross-linked homopolymeric ionizable monomers wherein the ionizable network is covalently attached to an amphiphilic copolymer to form a plurality of ‘dangling chains’ and wherein the ‘dangling chains’ of amphiphilic copolymer form immobile micelle-like aggregates in aqueous solution. A responsive microgel is further provided that comprises at least one therapeutic entity and delivers a substantially linear and sustained release of the therapeutic entity under physiological conditions.

  本发明提供了一种响应型微凝胶，该微凝胶可对选自由温度、pH 值和离子条件组成的组中的一种或多种水性条件的变化作出体积上和可逆的响应、和离子条件）组成的共价交联均聚可离子化单体的可离子化网络，其中可离子化网络与两性共聚物共价连接，形成多条 "悬链"，两性共聚物的 "悬链 "在水溶液中形成不动的胶束状聚集体。还提供了一种响应性微凝胶，它包含至少一种治疗实体，并能在生理条件下提供治疗实体的线性和持续释放。
• YUKI, HEIMEI;OKAMOTO, YOSHIO
  作者：YUKI, HEIMEI、OKAMOTO, YOSHIO

  DOI：——

  日期：——
• Polimerization process of optically active polymer and catalyst therefor
  申请人：DAICEL CHEMICAL INDUSTRIES, LTD.

  公开号：EP0089530B1

  公开（公告）日：1988-06-29