Trifluoro-methanesulfonic acid 5-cyano-3'-methoxy-biphenyl-2-yl ester | 565203-89-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Trifluoro-methanesulfonic acid 5-cyano-3'-methoxy-biphenyl-2-yl ester
• CAS: 565203-89-6
• 化学式: C₁₅H₁₀F₃NO₄S
• 分子量: 357.31
• InChiKey: NVBUCXAWFYHPNG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.46
• 重原子数：
  24.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  76.39
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  Trifluoro-methanesulfonic acid 5-cyano-3'-methoxy-biphenyl-2-yl ester 在 甲醇 、 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 叔丁基锂 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 6-{3-[3-(4-cyano-benzyl)-3H-imidazol-4-yl]-3-hydroxy-prop-1-ynyl}-3'-methoxy-biphenyl-3-carbonitrile
  参考文献：
  名称：

  Synthesis and biological evaluation of 1-benzyl-5-(3-biphenyl-2-yl-propyl)-1H-imidazole as novel farnesyltransferase inhibitor

  摘要：

  Farnesyltransferase inhibitors (FTIs) have emerged as a novel class of anti-cancer agents. Analogs of the potent FTI, 1-benzyl-5-(3-biphenyl-2-yl-propyl)-1H-imidazole, were synthesized and tested in vitro for their inhibitory activities. The most promising compound identified from this series is analog 29 that possesses potent enzymatic and cellular activities. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.07.083
• 作为产物：
  描述：

  3-碘-4-甲氧基苯甲腈 在 四(三苯基膦)钯 、 二乙基异丙基胺 、 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 生成 Trifluoro-methanesulfonic acid 5-cyano-3'-methoxy-biphenyl-2-yl ester
  参考文献：
  名称：

  Synthesis and biological evaluation of 4-[3-biphenyl-2-yl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile as novel farnesyltransferase inhibitor

  摘要：

  Farnesyltransferase inhibitors (FTIs) have emerged as a novel class of anti-cancer agents. Analogues of the potent FTI, 4-[3-biphenyl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile, were synthesized and tested in vitro for their inhibitory activities. The synthesis and detailed biological data of this series of analogues are presented. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00122-7