copper (I) 2-ethylhexanoate | 161189-84-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: copper (I) 2-ethylhexanoate
• 英文别名: copper 2-ethylhexanoate；2-Ethylhexanoic acid, copper salt；copper(1+);2-ethylhexanoate
• CAS: 161189-84-0；22221-10-9
• 化学式: C₈H₁₅O₂*Cu
• 分子量: 206.752
• InChiKey: WRTFVVOZYCEDQD-UHFFFAOYSA-M

物化性质

• 熔点：
  252 °C (dec.)(lit.)
• 密度：
  1.18[at 20℃]

计算性质

• 辛醇/水分配系数(LogP)：
  0.95
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  40.1
• 氢给体数：
  0
• 氢受体数：
  2

制备方法与用途

用途：可用于涂料、防腐剂以及电缆防水剂等领域。

反应信息

• 作为产物：
  描述：

  2-乙基己酸乙烯酯 在 copper diacetate 作用下， 生成 copper (I) 2-ethylhexanoate
  参考文献：
  名称：

  Synthesis of higher vinyl esters from ethylene and higher carboxylic acids

  摘要：

  生产含有至少四个碳原子的乙烯羧酸酯的均相液相过程，该过程包括（1）形成一个均相液体反应混合物，其中包含乙烯、至少含有三个碳原子的羧酸、钯（II）催化剂和铜（II）氧化剂；（2）在维持乙烯和羧酸在均相液体反应混合物中反应形成乙烯羧酸酯的条件下，维持反应混合物，但在该过程中至少存在以下条件之一：（i）铜（II）氧化剂是一种铜（II）羧酸盐，其中羧酸盐的分子量高于羧酸中羧酸基的分子量；（ii）钯（II）催化剂在反应混合物中通过氧化钯（0）胶体形成；和/或（iii）反应混合物还包含一种聚乙二醇醚化合物作为促进剂。

  公开号：

  EP0648734A1

文献信息

• METHOD FOR PRODUCING PHENYL-SUBSTITUTED HETEROCYCLIC DERIVATIVE BY MEANS OF COUPLING METHOD USING PALLADIUM COMPOUND
  申请人：Komiyama Masato

  公开号：US20130158272A1

  公开（公告）日：2013-06-20

  The present invention provides a method for producing a xanthine oxidase inhibitor, which is a therapeutic agent for hyperuricemia, or intermediates of the same, said method being efficient and using a short process. The present invention is a novel coupling method for obtaining a compound represented by formula (3) by bringing about a coupling reaction between a compound represented by formula (1) and a compound represented by formula (2), in the presence of a palladium compound, a ligand capable of coordinating to the palladium compound, a base, a C 1 -C 40 carboxylic acid, and at least one kind of additive.

  本发明提供了一种生产黄嘌呤氧化酶抑制剂的方法，该抑制剂是治疗高尿酸血症的药物，或者其中间体，该方法高效且使用流程简短。本发明是一种新型耦合方法，通过在钯化合物、能够配位到钯化合物的配体、碱、C1-C40羧酸和至少一种添加剂的存在下，在式（1）所代表的化合物和式（2）所代表的化合物之间引发耦合反应，从而获得式（3）所代表的化合物。
• Process for the isomerisation of internal olefines into 1-olefines and process for making an alkyl aluminum compound from an internal olefin
  申请人：ALBEMARLE CORPORATION

  公开号：EP0505834A1

  公开（公告）日：1992-09-30

  Linear 1-olefins are prepared from internal olefins by (i) reacting them in the presence of an isomerization catalyst and a tri-lower alkyl aluminum so as to cause the internal olefin to isomerize to 1-olefins which displace the lower alkyl groups to form a trialkyl aluminum compound in which at least one of the alkyl groups is a linear alkyl derived from the 1-olefin, and, thereafter, (ii) reacting the trialkyl aluminum compound with a 1-olefin so as to displace the linear alkyl from the trialkyl aluminum compound, thereby forming a linear 1-olefin product which is substantially free of internal olefins.

  线性 1-烯烃是由内烯烃通过以下方法制备的：(i) 在异构化催化剂和三低级烷基铝的存在下，使内烯烃与 1-烯烃发生异构化反应，从而置换出低级烷基，形成三烷基铝化合物，其中至少有一个烷基是由 1-烯烃衍生出的线性烷基、然后，(ii) 将三烷基铝化合物与 1-烯烃反应，使线性烷基从三烷基铝化合物中置换出来，从而形成基本上不含内部烯烃的线性 1-烯烃产品。
• Continuous process for preparing aluminum alkyls and linear 1-olefins from internal olefins
  申请人：ALBEMARLE CORPORATION

  公开号：EP0525760A1

  公开（公告）日：1993-02-03

  Linear 1-olefins are continuously prepared from internal olefins by (i) continuously feeding internal olefin, isomerization catalyst and tri-lower alkyl aluminum to a reaction zone so as to cause the internal olefin to isomerize to 1-olefins which displace the lower alkyl groups to form a trialkyl aluminum compound in which at least one of the alkyl groups is a linear alkyl derived from the 1-olefin, (ii) continuously removing trialkylaluminum compound from the reaction zone and, thereafter, (iii) reacting the trialkyl aluminum compound with a 1-olefin so as to displace the linear alkyl from the trialkyl aluminum compound, thereby forming a linear 1- olefin product which is substantially free of internal olefins.

  线性 1-烯烃是通过以下方法从内部烯烃连续制备的：(i) 将内部烯烃、异构化催化剂和三低级烷基铝连续加入反应区，使内部烯烃异构化为 1-烯烃，从而置换出低级烷基，形成三烷基铝化合物，其中至少一个烷基是来自 1-烯烃的线性烷基、(ii) 从反应区连续移除三烷基铝化合物，然后，(iii) 使三烷基铝化合物与 1-烯烃反应，以置换三烷基铝化合物中的直链烷基，从而形成基本上不含内部烯烃的直链 1-烯烃产品。
• Preparation of linear alpha-olefins by a modified chain growth process
  申请人：ALBEMARLE CORPORATION

  公开号：EP0602565A1

  公开（公告）日：1994-06-22

  Linear alpha-olefin products which are enriched in one or more olefins of a selected carbon number are prepared by an ethylene chain growth process starting with a trialkylaluminum compound represented by the formula AlR₃, in which each R group contains 3 to 10 carbon atoms, adding an average number of ethylene units to the R groups so as to form aluminum alkyls which are enriched in R groups having the selected carbon number, recovering the alpha-olefin products from the aluminum alkyls by catalyzed alkyl displacement, and recycling the trialkylaluminum product of the displacement to the chain growth reaction.

  富含一种或多种选定碳数烯烃的线性α-烯烃产品是通过乙烯链增长工艺制备的，该工艺以式 AlR₃代表的三烷基铝化合物为起点，其中每个 R 基含有 3 至 10 个碳原子、向 R 基团中添加平均数量的乙烯单元，以形成富含具有选定碳数的 R 基团的铝烷基，通过催化烷基置换从铝烷基中回收α-烯烃产物，并将置换产物中的三烷基铝回收到链增长反应中。
• METHOD FOR PRODUCING PHENYL-SUBSTITUTED HETEROCYCLIC DERIVATIVE BY MEANS OF COUPLING METHOD USING A PALLADIUM COMPOUND
  申请人：Teijin Pharma Limited

  公开号：EP2610248A1

  公开（公告）日：2013-07-03

  The present invention provides a method for producing a xanthine oxidase inhibitor, which is a therapeutic agent for hyperuricemia, or intermediates of the same, said method being efficient and using a short process. The present invention is a novel coupling method for obtaining a compound represented by formula (3) by bringing about a coupling reaction between a compound represented by formula (1) and a compound represented by formula (2), in the presence of a palladium compound, a ligand capable of coordinating to the palladium compound, a base, a C1-C40 carboxylic acid, and at least one kind of additive.

  本发明提供了一种生产作为高尿酸血症治疗药物的黄嘌呤氧化酶抑制剂或其中间体的方法，所述方法高效且工艺流程短。本发明是一种新颖的偶联方法，通过在钯化合物、能与钯化合物配位的配体、碱、C1-C40 羧酸和至少一种添加剂存在下，使式（1）代表的化合物与式（2）代表的化合物发生偶联反应，得到式（3）代表的化合物。