(Z)-4,4,5,5-Tetrafluoro-3-hydroxy-pent-2-enoic acid methyl ester | 113341-47-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (Z)-4,4,5,5-Tetrafluoro-3-hydroxy-pent-2-enoic acid methyl ester
• 英文别名: methyl (Z)-4,4,5,5-tetrafluoro-3-hydroxypent-2-enoate
• CAS: 113341-47-2
• 化学式: C₆H₆F₄O₃
• 分子量: 202.105
• InChiKey: VLRNUCHTONRFHZ-IHWYPQMZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (Z)-4,4,5,5-Tetrafluoro-3-hydroxy-pent-2-enoic acid methyl ester 生成 methyl 3-oxo-4,4,5,5-tetrafluoropentanoate
  参考文献：
  名称：

  RUDAYA M. N.; SALOUTIN V. I.; FOMIN A. N.; PASHKEVICH K. I., IZV. AN CCCP. CEP. XIM.,(1987) N 6, 1412-1415

  摘要：

  DOI：
• 作为产物：
  描述：

  methyl 3-oxo-4,4,5,5-tetrafluoropentanoate 生成 (Z)-4,4,5,5-Tetrafluoro-3-hydroxy-pent-2-enoic acid methyl ester
  参考文献：
  名称：

  RUDAYA M. N.; SALOUTIN V. I.; FOMIN A. N.; PASHKEVICH K. I., IZV. AN CCCP. CEP. XIM.,(1987) N 6, 1412-1415

  摘要：

  DOI：

文献信息

• ——
  作者：M. V. Pryadeina、O. G. Kuzueva、Ya. V. Burgart、V. I. Saloutin

  DOI：10.1023/a:1015565700648

  日期：——

  Depending on conditions, fluorinated 3-oxoesters in reactions with benzaldehyde afford either 2-benzylidene-3-fluoroalkyl-3-oxoesters or 3,5-dialkoxycarbonyl-2,6-dihydroxy-2,6-difluoroalkyl-4-phenyltetrahydropyrans. The latter were also obtained by treating 3-oxoesters with 2-benzylidene-3-oxoesters. Pentafluorobenzoylacetate with benzaldehyde furnishes 3,5-diethoxycarbonyl-2-pentafluorophenyl-4-phenyl-7,8,9,10-tetrafluoro-4,5-dihydrobenzo[b]oxacin-6-one.
• Synthesis of 7-Alkyl(aryl)-6-alkoxycarbonyl-5-fluoroalkyl-1,2,4-tri(tetr)azolo[1,5-a]pyrimidines
  作者：M. V. Pryadeina、Ya. V. Burgart、V. I. Saloutin、M. I. Kodess、E. N. Ulomskii、V. L. Rusinov

  DOI：10.1023/b:rujo.0000044558.47152.65

  日期：2004.6

  Fluorinated 3-oxo esters react with aldehydes and 3-amino-1,2,4-triazoles and 5-aminotetrazoles to give, respectively, 7-alkyl(aryl)-6-alkoxycarbonyl-5-fluoroalkyl-1,2,4-triazolo [1,5-a] pyrimidines and -tetrazolo[1,5-a]pyrimidines. The same heterocyclic products can be obtained by reaction of 2-benzylidene-2fluoroacyl esters with the corresponding aminoazoles.
• RUDAYA M. N.; SALOUTIN V. I.; FOMIN A. N.; PASHKEVICH K. I., IZV. AN CCCP. CEP. XIM.,(1987) N 6, 1412-1415
  作者：RUDAYA M. N.、 SALOUTIN V. I.、 FOMIN A. N.、 PASHKEVICH K. I.

  DOI：——

  日期：——