(2S,4R)-2-((E)-2-Isoxazol-5-yl-vinyl)-4-methanesulfonyloxy-pyrrolidine-1-carboxylic acid allyl ester | 326605-16-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (2S,4R)-2-((E)-2-Isoxazol-5-yl-vinyl)-4-methanesulfonyloxy-pyrrolidine-1-carboxylic acid allyl ester
• 英文别名: prop-2-enyl (2S,4R)-4-methylsulfonyloxy-2-[(E)-2-(1,2-oxazol-5-yl)ethenyl]pyrrolidine-1-carboxylate
• CAS: 326605-16-7
• 化学式: C₁₄H₁₈N₂O₆S
• 分子量: 342.373
• InChiKey: QODHIFOFCQPYOQ-WPCUQIPDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  107
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (2S,4R)-2-((E)-2-Isoxazol-5-yl-vinyl)-4-methanesulfonyloxy-pyrrolidine-1-carboxylic acid allyl ester 在 甲醇 、 sodium hydroxide 作用下， 以 N,N-二甲基甲酰胺 、 丙酮 为溶剂， 反应 5.0h， 生成 (2S,4S)-2-((E)-2-Isoxazol-5-yl-vinyl)-4-mercapto-pyrrolidine-1-carboxylic acid allyl ester
  参考文献：
  名称：

  Synthesis and biological activity of 1β-methyl-2-[5′-isoxazoloethenylpyrrolidin-3′-ylthio]carbapenems

  摘要：

  A new series of 1 beta -methylcarbapenems 1a-i bearing isoxazoloethenyl groups on the pyrrolidine ring has been prepared and evaluated for in vitro antibacterial activity and stability to DHP-I. Most compounds showed excellent antibacterial activity and high stability to DHP-I superior to that of meropenem. Of these new carbapenems, 1a,b,h exhibited the best combination of antibacterial activity and DHP-I stability. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00575-8
• 作为产物：
  描述：

  (5-isoxazolylmethyl)-triphenylphosphonium bromide 、 (2S,4R)-4-methanesulfonyloxy-2-formyl-1-allyloxy-carbonylpyrrolidine 在 sodium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 反应 5.0h， 生成 (2S,4R)-2-((Z)-2-Isoxazol-5-yl-vinyl)-4-methanesulfonyloxy-pyrrolidine-1-carboxylic acid allyl ester 、 (2S,4R)-2-((E)-2-Isoxazol-5-yl-vinyl)-4-methanesulfonyloxy-pyrrolidine-1-carboxylic acid allyl ester
  参考文献：
  名称：

  Synthesis and biological activity of 1β-methyl-2-[5′-isoxazoloethenylpyrrolidin-3′-ylthio]carbapenems

  摘要：

  A new series of 1 beta -methylcarbapenems 1a-i bearing isoxazoloethenyl groups on the pyrrolidine ring has been prepared and evaluated for in vitro antibacterial activity and stability to DHP-I. Most compounds showed excellent antibacterial activity and high stability to DHP-I superior to that of meropenem. Of these new carbapenems, 1a,b,h exhibited the best combination of antibacterial activity and DHP-I stability. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00575-8