[(3-but-3-en-1-yl-3-methylcyclohex-1-en-1-yl)methyl](trimethyl)silane | 1236206-96-4

• 分子结构分类: 有机化合物 - 碳氢化合物衍生物
• 英文名称: [(3-but-3-en-1-yl-3-methylcyclohex-1-en-1-yl)methyl](trimethyl)silane
• 英文别名: (3-But-3-enyl-3-methylcyclohexen-1-yl)methyl-trimethylsilane
• CAS: 1236206-96-4
• 化学式: C₁₅H₂₈Si
• 分子量: 236.473
• InChiKey: RNSOYJYPECWDBS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.41
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  [(3-but-3-en-1-yl-3-methylcyclohex-1-en-1-yl)methyl](trimethyl)silane 在 四氧化锇 、 N-甲基吗啉氧化物 、 sodium periodate 作用下， 以 1,4-二氧六环 、 水 为溶剂， 以59%的产率得到
  参考文献：
  名称：

  Efficient formal synthesis of (±)-axamide-1 and (±)-axisonitrile-1 via an intramolecular Hosomi–Sakurai reaction

  摘要：

  A formal synthesis of (+/-)-axamide-1 and (+/-)-axisonitrile-1 was achieved by using an intramolecular Hosomi-Sakurai reaction of the allylsilane derivative, as a key step, in which [(3-but-3-en-1-yl-3-methylcyclohex-1-en-1-yl)methyl](trimethyl)silane was transformed to a bicyclic compound possessing a core carbon framework under the oxidative dihydroxylation reaction conditions, in one step. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.04.119
• 作为产物：
  描述：

  (3-But-3-enyl-3-methylcyclohexen-1-yl) trifluoromethanesulfonate 、 (三甲基硅基)甲基氯化镁 在 四(三苯基膦)钯 作用下， 以 四氢呋喃 为溶剂， 反应 2.5h， 以93%的产率得到[(3-but-3-en-1-yl-3-methylcyclohex-1-en-1-yl)methyl](trimethyl)silane
  参考文献：
  名称：

  Efficient formal synthesis of (±)-axamide-1 and (±)-axisonitrile-1 via an intramolecular Hosomi–Sakurai reaction

  摘要：

  A formal synthesis of (+/-)-axamide-1 and (+/-)-axisonitrile-1 was achieved by using an intramolecular Hosomi-Sakurai reaction of the allylsilane derivative, as a key step, in which [(3-but-3-en-1-yl-3-methylcyclohex-1-en-1-yl)methyl](trimethyl)silane was transformed to a bicyclic compound possessing a core carbon framework under the oxidative dihydroxylation reaction conditions, in one step. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.04.119

文献信息

• Efficient formal synthesis of (±)-axamide-1 and (±)-axisonitrile-1 via an intramolecular Hosomi–Sakurai reaction
  作者：Kazunori Takahashi、Kentaro Takeda、Toshio Honda

  DOI：10.1016/j.tetlet.2010.04.119

  日期：2010.7

  A formal synthesis of (+/-)-axamide-1 and (+/-)-axisonitrile-1 was achieved by using an intramolecular Hosomi-Sakurai reaction of the allylsilane derivative, as a key step, in which [(3-but-3-en-1-yl-3-methylcyclohex-1-en-1-yl)methyl](trimethyl)silane was transformed to a bicyclic compound possessing a core carbon framework under the oxidative dihydroxylation reaction conditions, in one step. (C) 2010 Elsevier Ltd. All rights reserved.