2-(1H-benzo[d][1,2,3]triazol-5-yl)acetic acid | 491612-10-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并三唑类
• 英文名称: 2-(1H-benzo[d][1,2,3]triazol-5-yl)acetic acid
• 英文别名: 2-(1H-1,2,3-benzotriazol-5-yl)acetic acid；2-(2H-benzotriazol-5-yl)acetic acid
• CAS: 491612-10-3
• 化学式: C₈H₇N₃O₂
• 分子量: 177.162
• InChiKey: AORIVBNPDYSFES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  78.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(1H-benzo[d][1,2,3]triazol-5-yl)acetic acid 在 manganese(IV) oxide 、 lithium aluminium tetrahydride 、 硫酸 作用下， 以 四氢呋喃 、 二氯甲烷 、 乙酸乙酯 为溶剂， 反应 120.0h， 生成 1H-苯并[d][1,2,3]噻唑-5-甲醛
  参考文献：
  名称：

  Substituted Pyran Derivatives

  摘要：

  提供了在单胺转运系统上表现出强效活性的某些3,6-二取代和2,4,5-三取代吡喃衍生物。这些3,6和2,4,5吡喃物在探究它们与单胺转运体系的结合效应以及与影响中枢神经系统的各种疾病之间的关系，或作为治疗涉及单胺转运和相关系统的各种中枢神经系统相关疾病的方法中是有用的。

  公开号：

  US20140309427A1
• 作为产物：
  描述：

  2-(3,4-二氨基苯基)乙酸乙酯 在 水 、 溶剂黄146 、 sodium hydroxide 、 sodium nitrite 作用下， 以 乙醇 、 水 为溶剂， 反应 6.0h， 生成 2-(1H-benzo[d][1,2,3]triazol-5-yl)acetic acid
  参考文献：
  名称：

  HETEROCYCLIC COMPOUNDS AS AUTOTAXIN INHIBITORS

  摘要：

  式（I）中的化合物，其中Het、R、X、Y、R1和p具有权利要求1中所示的含义，是自动税酯酶抑制剂，可用于治疗肿瘤。

  公开号：

  US20120015959A1

文献信息

• USE OF T-TYPE CALCIUM CHANNEL BLOCKER FOR TREATING PRURITUS
  申请人：Nippon Chemiphar Co., Ltd.

  公开号：EP3950059A1

  公开（公告）日：2022-02-09

  A medicament for treating or preventing pruritus is provided. For the medicament for treating or preventing pruritus, a compound having a blocking action on Cav3.2T-type calcium channels represented by General Formulas (I) to (VI), a tautomer of the compound, a stereoisomer of the compound, a pharmaceutically acceptable salt thereof, or a solvate thereof is used as an active ingredient.

  提供一种用于治疗或预防瘙痒的药物。用于治疗或预防瘙痒的药物中，使用具有对Cav3.2T型钙通道具有阻断作用的化合物，该化合物以一般式(I)至(VI)表示，该化合物的互变异构体、立体异构体、其药用可接受的盐或其溶剂为活性成分。
• CURABLE SILICONE COMPOSITION AND OPTICAL SEMICONDUCTOR DEVICE
  申请人：Dow Corning Toray Co., Ltd.

  公开号：EP2930213A1

  公开（公告）日：2015-10-14

  A curable silicone composition which is composed of at least (A) an organopolysiloxane having at least two silicon atom-bonded alkenyl groups in each molecule, (B) an organopolysiloxane having at least two silicon atom-bonded hydrogen atoms in each molecule, (C) at least one fine powder that is selected from the group consisting of fine zinc oxide powders that are surface-coated with an oxide and/or hydroxide of at least one element that is selected from the group consisting of Al, Ag, Cu, Fe, Sb, Si, Sn, Ti, Zr and rare earth elements, fine zinc oxide powders that are surface-coated with an organosilicon compound having no alkenyl group, and fine powders of zinc carbonate hydrates, and (D) a catalyst for hydrosilylation reaction. This curable silicone composition has excellent storage stability, and is cured to form a cured product that is suppressed in yellowing due to thermal aging and that sufficiently suppresses discoloration of a silver electrode or silver plating of a substrate in an optical semiconductor device, said discoloration being caused by a sulfur-containing gas in the air

  一种可固化的有机硅组合物，它至少由以下物质组成：(A) 一种有机聚硅氧烷，其每个分子中至少有两个硅原子键合的烯基；(B) 一种有机聚硅氧烷，其每个分子中至少有两个硅原子键合的氢原子、(C) 至少一种细粉末，选自由 Al、Ag、Cu、Fe、Sb、Si、Sn、Ti、Zr 和稀土元素组成的组中至少一种元素的氧化物和/或氢氧化物表面包覆的细氧化锌粉末、无烯基的有机硅化合物表面包覆的细氧化锌粉末和碳酸锌水合物细粉末组成的组；以及 (D) 水硅烷化反应催化剂。这种可固化有机硅组合物具有极佳的储存稳定性，固化后形成的固化产品可抑制热老化引起的黄变，并能充分抑制光学半导体器件中银电极或基底镀银的变色，所述变色是由空气中的含硫气体引起的。
• CURABLE SILICONE COMPOSITION, CURED OBJECT THEREOF, AND OPTICAL SEMICONDUCTOR DEVICE
  申请人：Dow Corning Toray Co., Ltd.

  公开号：EP3103843A1

  公开（公告）日：2016-12-14

  A curable silicone composition comprising: (A) an organopolysiloxane represented by the average unit formula: (R13SiO1/2)a(R22SiO2/2)b(R3SiO3/2)c (R1 are alkyl groups, alkenyl groups, aryl groups, or aralkyl groups; R2 are alkyl groups or alkenyl groups; R3 is an alkyl group, aryl group, or an aralkyl group, provided that, in a molecule, at least 0.5 mol% of R1 to R3 are the alkenyl groups, at least one of R3 is the aryl group or the aralkyl group; and a, b, and c are numbers satisfying: 0.01 ≤ a ≤ 0.5, 0.4 ≤ b ≤ 0.8, 0.01 ≤ c ≤ 0.5, and a + b + c = 1); (B) an organopolysiloxane that is different from component (A); (C) an organopolysiloxane having at least two silicon atom-bonded hydrogen atoms in a molecule; and (D) a hydrosilylation reaction catalyst. A cured product exhibiting excellent dispersibility of phosphor and having high strength and gas barrier properties is formed.

  一种可固化的有机硅组合物，包括： (A) 由平均单元式表示的有机聚硅氧烷：(R13SiO1/2)a(R22SiO2/2)b(R3SiO3/2)c(R1是烷基、烯基、芳基或芳烷基；R2是烷基或烯基；R3是烷基、芳基或芳烷基，条件是在一个分子中，至少0.5 mol%的R1至R3是烯基，R3中至少有一个是芳基或芳烷基；a、b和c是满足以下条件的数字：0.01≤a≤0.5，0.4≤b≤0.8，0.01≤c≤0.5，且a＋b＋c＝1）；(B)不同于组分(A)的有机聚硅氧烷；(C)分子中至少有两个硅原子键合氢原子的有机聚硅氧烷；以及(D)加氢硅烷化反应催化剂。这样就形成了一种具有优异的荧光粉分散性、高强度和气体阻隔性的固化产品。
• ORGANOSILOXANE, CURABLE SILICONE COMPOSITION, AND SEMICONDUCTOR DEVICE
  申请人：Dow Corning Toray Co., Ltd.

  公开号：EP3153517A1

  公开（公告）日：2017-04-12

  An organosiloxane represented by the following general formula; a curable silicone composition comprising: (A) an organopolysiloxane having at least two alkenyl groups in a molecule; (B) an organohydrogenpolysiloxane having at least two silicon atom-bonded hydrogen atoms in a molecule; (C) an adhesion promoter containing the organosiloxane; and (D) a catalyst for hydrosilylation reaction; and a semiconductor device in which a semiconductor element is encapsulated with a cured product of the composition. A novel organosiloxane, a curable silicone composition that contains the novel organosiloxane as an adhesion promoter and that forms a cured product having excellent adhesion to various base materials, and a semiconductor device that is formed by using the composition and that has excellent reliability are provided.

  一种由以下通式表示的有机硅氧烷；一种可固化的有机硅组合物，其中包括：(A)分子中至少有两个烯基的有机聚硅氧烷；(B)分子中至少有两个硅原子键合氢原子的有机氢聚硅氧烷；(C)含有该有机硅氧烷的附着力促进剂；以及(D)用于氢化硅烷化反应的催化剂；以及一种半导体器件，其中的半导体元件用该组合物的固化产物封装。本发明提供了一种新型有机硅氧烷、一种含有该新型有机硅氧烷作为附着力促进剂并能形成与各种基底材料具有优异附着力的固化产物的可固化硅氧烷组合物，以及一种通过使用该组合物形成并具有优异可靠性的半导体器件。
• ORGANIC SILICON COMPOUND, CURABLE SILICONE COMPOSITION, AND SEMICONDUCTOR DEVICE
  申请人：Dow Corning Toray Co., Ltd.

  公开号：EP3153516A1

  公开（公告）日：2017-04-12

  An organosilicon compound represented by the general formula, a hydrosilylation- curable silicone composition containing the compound as an adhesion promoter, and a semiconductor device having a semiconductor element sealed with a cured product of the composition. To provide a novel organosilicon compound, a curable silicone composition that contains the organosilicon compound as an adhesion promoter, has excellent initial adhesion and adhesion durability to a base material such as an organic resin, and forms a cured product having high light transmittance, and a highly reliable semiconductor device produced using this composition.

  一种由通式表示的有机硅化合物、一种含有该化合物作为附着力促进剂的水硅烷化固化型有机硅组合物，以及一种具有用该组合物的固化产物密封的半导体元件的半导体器件。提供一种新型有机硅化合物、一种含有该有机硅化合物作为附着力促进剂、与有机树脂等基体材料具有优异的初始附着力和附着耐久性并能形成具有高透光率的固化产物的可固化有机硅组合物，以及一种使用该组合物生产的高可靠性半导体器件。