(Z)-(2S)-3-[4-(3-biphenyl-4-yl-3-phenyl-allyloxy)-phenyl]-2-ethoxy-propionic acid ethyl ester | 303110-71-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Z)-(2S)-3-[4-(3-biphenyl-4-yl-3-phenyl-allyloxy)-phenyl]-2-ethoxy-propionic acid ethyl ester
• 英文别名: (E,Z)-(2S)-3-[4-(3-Biphenyl-4-yl-3-phenyl-allyloxy)-phenyl]-2-ethoxy-propionic acid ethyl ester；ethyl (2S)-2-ethoxy-3-[4-[(Z)-3-phenyl-3-(4-phenylphenyl)prop-2-enoxy]phenyl]propanoate
• CAS: 303110-71-6
• 化学式: C₃₄H₃₄O₄
• 分子量: 506.642
• InChiKey: IDTLQWXOVARKBI-GSLVUUQMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.3
• 重原子数：
  38
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (Z)-(2S)-3-[4-(3-biphenyl-4-yl-3-phenyl-allyloxy)-phenyl]-2-ethoxy-propionic acid ethyl ester 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 生成 (Z)-(2S)-3-[4-(3-biphenyl-4-yl-3-phenyl-allyloxy)-phenyl]-2-ethoxy-propionic acid
  参考文献：
  名称：

  Design and synthesis of novel PPARα/γ/δ triple activators using a known PPARα/γ dual activator as structural template

  摘要：

  Using a known dual PPARalpha/gamma activator (5) as a structural template, SAR evaluations led to the identification of triple PPARalpha/gamma/delta activators (18-20) with equal potency and efficacy on all three receptors. These compounds could become useful tools for studying the combined biological effects of PPARalpha/gamma/delta activation. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00881-8
• 作为产物：
  描述：

  4-苯基二苯甲酮 在 三叔丁基膦 、 sodium ethanolate 、 二异丁基氢化铝 、 1,1'-azodicarbonyl-dipiperidine 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 生成 (Z)-(2S)-3-[4-(3-biphenyl-4-yl-3-phenyl-allyloxy)-phenyl]-2-ethoxy-propionic acid ethyl ester
  参考文献：
  名称：

  Design and synthesis of novel PPARα/γ/δ triple activators using a known PPARα/γ dual activator as structural template

  摘要：

  Using a known dual PPARalpha/gamma activator (5) as a structural template, SAR evaluations led to the identification of triple PPARalpha/gamma/delta activators (18-20) with equal potency and efficacy on all three receptors. These compounds could become useful tools for studying the combined biological effects of PPARalpha/gamma/delta activation. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00881-8

文献信息

• Compounds, their preparation and use
  申请人：Murray Anthony

  公开号：US06972294B1

  公开（公告）日：2005-12-06

  Disclosed are novel compounds of formula (I) wherein A 1 , A 2 , Ar, R 5 , R 6 , R 8 , M, Q, Y, Z, k, m and n are as defined in the specification. These compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR). Such conditions include diabetes and obesity.

  揭示了一种新的化合物，其化学式为(I)，其中A1、A2、Ar、R5、R6、R8、M、Q、Y、Z、k、m和n的定义如规范中所述。这些化合物在治疗和/或预防由核受体介导的疾病方面具有用途，特别是过氧化物酶体增殖激活受体（PPAR）。这些疾病包括糖尿病和肥胖症。
• [EN] NEW COMPOUNDS, THEIR PREPARATION AND USE<br/>[FR] NOUVEAUX COMPOSES, PREPARATION ET UTILISATION DE CES DERNIERS
  申请人：NOVO NORDISK AS

  公开号：WO2000063153A1

  公开（公告）日：2000-10-26

  The present invention relates to compounds of general formula (I) The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).

  本发明涉及一般式（I）的化合物。该化合物可用于治疗和/或预防由核受体介导的疾病，特别是过氧化物酶体增殖物激活受体（PPAR）。
• COMPOUNDS, THEIR PREPARATION AND USE
  申请人：NOVO NORDISK A/S

  公开号：EP1171414A1

  公开（公告）日：2002-01-16
• JP2002542218A
  申请人：——

  公开号：JP2002542218A

  公开（公告）日：2002-12-10
• US6972294B1
  申请人：——

  公开号：US6972294B1

  公开（公告）日：2005-12-06