tert-butyl N-[2-[2-[2-(4-aminobutoxy)ethoxy]ethoxy]ethyl]carbamate | 1203507-47-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-butyl N-[2-[2-[2-(4-aminobutoxy)ethoxy]ethoxy]ethyl]carbamate
• CAS: 1203507-47-4
• 化学式: C₁₅H₃₂N₂O₅
• 分子量: 320.429
• InChiKey: MFJKRSWREUXJCB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  22
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  92
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  11,12-didehydro-5,6-dihydrodibenzo[a,e]cycloocten-5-yl carbonic acid 4-nitrophenyl ester 、 tert-butyl N-[2-[2-[2-(4-aminobutoxy)ethoxy]ethoxy]ethyl]carbamate 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以68%的产率得到
  参考文献：
  名称：

  Noncovalent Cell Surface Engineering with Cationic Graft Copolymers

  摘要：

  Chemical approaches to cell surface engineering have emerged as powerful tools for resurfacing the molecular landscape of cells and tissues. Here we report a new strategy for re-engineering cell surfaces through electrostatic adsorption of appropriately structured and functionalized Poly (L-lysine)-graft-poly(ethylene glycol) (PLL-g-PEG) copolymers to cellular interfaces. Grafting of methoxy terminated tetra(ethylene glycol) chains to PLL abrogated polycation cytotoxicity in a charge density and PEG dependent manner, and copolymers structured with a unique balance of grafted PEG chains and free lysine monomers adsorbed to cell surfaces without compromising viability. Structurally analogous PLL-g-PEG copolymers bearing terminally functionalized PEG grafts were used as 'cell surface active' polymeric carriers for biotin, hydrazide, and azide moieties, which selectively captured streptavidin-, aldehyde-, and cyclooctyne-labeled probes, respectively, on cell surfaces. This strategy opens new opportunities in cell surface engineering, including generation of unique cell surface motifs, rapid and combinatorial surface modification, and use of biologically complex solvents. Tailored PLL-g-PEG copolymers offer a promising and enabling tool for bio/chemically remodeling cells and tissues with broad potential in biomedical and biotechnological applications.

  DOI：

  10.1021/ja908887v

文献信息

• Dendrimers and methods for their preparation and use
  申请人：DAKO A/S

  公开号：US20030077635A1

  公开（公告）日：2003-04-24

  Novel dendrimers as well as novel dendrimer complexes are disclosed. Such dendrimers and/or dendrimer complexes may be used for the detection of various components of a sample and as detection systems and signal enhancement/amplification systems. The dendrimers and dendrimer complexes may also be used for labelling various entities/compounds. Furthermore, labelling kits and detection kits comprising one or more labelled dendrimers or one or more dendrimer complexes are also one of the possible uses.

  本发明公开了新型树状分子以及新型树状分子复合物。这些树状分子和/或树状分子复合物可用于检测样品中的各种组分，并用作检测系统和信号增强/放大系统。树状分子和树状分子复合物还可用于标记各种实体/化合物。此外，还可以使用包含一个或多个标记树状分子或一个或多个树状分子复合物的标记试剂盒和检测试剂盒。
• Noncovalent Cell Surface Engineering with Cationic Graft Copolymers
  作者：John T. Wilson、Venkata R. Krishnamurthy、Wanxing Cui、Zheng Qu、Elliot L. Chaikof

  DOI：10.1021/ja908887v

  日期：2009.12.30

  Chemical approaches to cell surface engineering have emerged as powerful tools for resurfacing the molecular landscape of cells and tissues. Here we report a new strategy for re-engineering cell surfaces through electrostatic adsorption of appropriately structured and functionalized Poly (L-lysine)-graft-poly(ethylene glycol) (PLL-g-PEG) copolymers to cellular interfaces. Grafting of methoxy terminated tetra(ethylene glycol) chains to PLL abrogated polycation cytotoxicity in a charge density and PEG dependent manner, and copolymers structured with a unique balance of grafted PEG chains and free lysine monomers adsorbed to cell surfaces without compromising viability. Structurally analogous PLL-g-PEG copolymers bearing terminally functionalized PEG grafts were used as 'cell surface active' polymeric carriers for biotin, hydrazide, and azide moieties, which selectively captured streptavidin-, aldehyde-, and cyclooctyne-labeled probes, respectively, on cell surfaces. This strategy opens new opportunities in cell surface engineering, including generation of unique cell surface motifs, rapid and combinatorial surface modification, and use of biologically complex solvents. Tailored PLL-g-PEG copolymers offer a promising and enabling tool for bio/chemically remodeling cells and tissues with broad potential in biomedical and biotechnological applications.