6-[(1,2-oxazinan-2-yl)sulfonyl]hexan-1-amine | 1170231-83-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 6-[(1,2-oxazinan-2-yl)sulfonyl]hexan-1-amine
• 英文别名: 6-[(1,2-Oxazinan-2-yl)sulfonyl]hexan-1-amine；6-(oxazinan-2-ylsulfonyl)hexan-1-amine
• CAS: 1170231-83-0
• 化学式: C₁₀H₂₂N₂O₃S
• 分子量: 250.362
• InChiKey: ILVVUWDGRINYCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  81
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6-[(1,2-oxazinan-2-yl)sulfonyl]hexan-1-amine 在 盐酸 、 三乙基硅烷 、 4-二甲氨基吡啶 、 tin 、 溶剂黄146 、 三乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 88.0h， 生成 2-{6-[(1,2-oxazinan-2-yl)sulfonyl]hexyl}-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one
  参考文献：
  名称：

  The synthesis of some sulfonamides based on 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine

  摘要：

  Synthetic protocols for the preparation of 1-oxo-, 3-oxo-, and 1,3-dioxopyrrolo[3,4-c] pyridines which contain sulfonamide groups linked to the pyrrole nitrogen atom of the pyrrolo[3,4-c] pyridine cycle by a flexible (CH2) 6 aliphatic linker were developed. 1,3-Dioxopyrrolo-[3,4-c] pyridines were obtained from 3,4-pyridinedicarboxylic acid by condensation of intermediate methyl 3-(chlorocarbonyl)isonicotinate with amines. 3-Oxopyrrolo[3,4-c] pyridines were prepared by regioselective reduction of 1,3-dioxopyrrolo[3,4-c] pyridines with a tin dust followed by treatment with triethylsilane. 1-Oxopyrrolo[3,4-c] pyridines were prepared by a synthetic sequence consisting of the treatment of methyl isonicotinate with N-bromosuccinimide and the following condensation of the obtained ethyl 3-bromomethylisonicotinate with primary amines.

  DOI：

  10.1007/s10593-015-1753-y

文献信息

• [EN] NOVEL CYANOGUANIDINES<br/>[FR] NOUVELLES CYANOGUANIDINES
  申请人：TOPOTARGET AS

  公开号：WO2009086835A1

  公开（公告）日：2009-07-16

  This application discloses novel cyanoguanidines of the formula (I) wherein A is selected from -C(=O)-, -S(=O)2-, -C(=S)-, and -P(=O)(R5)-, wherein R5 is selected from C1-6-alkyl, C1-6-alkoxy, and hydroxy; B is selected from a single bond, -O-, -NR6- and -C(=O)-NR6-, wherein R6 is selected from hydrogen, optionally substituted C1-12-alkyl, optionally substituted C1-12-alkenyl, optionally substituted aryl, optionally substituted heterocyclyl, and optionally substituted heteroaryl; and m is an integer of 0-12 and n is an integer of 0-12, wherein the sum m+n is 1-20; and R1 is selected from optionally substituted heteroaryl; and pharmaceutically acceptable salts thereof, and prodrugs thereof. The compounds are usefuld for use as a medicament for the treatment of a disease or a condition caused by an elevated level of nicotinamide phosphoribosyltransferase (NAMPRT).

  该申请公开了一种新型氰胍啶化合物，其化学式为（I），其中A从-C（=O）-，-S（=O）2-，-C（=S）-和-P（=O）（R5）-中选择，其中R5选择自C1-6-烷基，C1-6-烷氧基和羟基；B从单键，-O-，-NR6-和-C（=O）-NR6-中选择，其中R6选择自氢，可选择地取代的C1-12-烷基，可选择地取代的C1-12-烯基，可选择地取代的芳基，可选择地取代的杂环烷基和可选择地取代的杂环芳基；m为0-12的整数，n为0-12的整数，其中m+n之和为1-20；R1选择自可选择地取代的杂环芳基；以及其药学上可接受的盐和前药。这些化合物可用作治疗由烟酰胺磷酸核糖转移酶（NAMPRT）水平升高引起的疾病或病况的药物。
• The synthesis of some sulfonamides based on 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine
  作者：Martins Ikaunieks、Fredrik Björkling、Einars Loza

  DOI：10.1007/s10593-015-1753-y

  日期：2015.7

  Synthetic protocols for the preparation of 1-oxo-, 3-oxo-, and 1,3-dioxopyrrolo[3,4-c] pyridines which contain sulfonamide groups linked to the pyrrole nitrogen atom of the pyrrolo[3,4-c] pyridine cycle by a flexible (CH2) 6 aliphatic linker were developed. 1,3-Dioxopyrrolo-[3,4-c] pyridines were obtained from 3,4-pyridinedicarboxylic acid by condensation of intermediate methyl 3-(chlorocarbonyl)isonicotinate with amines. 3-Oxopyrrolo[3,4-c] pyridines were prepared by regioselective reduction of 1,3-dioxopyrrolo[3,4-c] pyridines with a tin dust followed by treatment with triethylsilane. 1-Oxopyrrolo[3,4-c] pyridines were prepared by a synthetic sequence consisting of the treatment of methyl isonicotinate with N-bromosuccinimide and the following condensation of the obtained ethyl 3-bromomethylisonicotinate with primary amines.