ethyl-malonic acid bis-methylamide | 857802-44-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ethyl-malonic acid bis-methylamide
• 英文别名: Aethyl-malonsaeure-bis-methylamid；Ethylmalonic acid bis(methyl amide)；2-ethyl-N,N'-dimethylpropanediamide
• CAS: 857802-44-9
• 化学式: C₇H₁₄N₂O₂
• 分子量: 158.2
• InChiKey: PEEBKGXBVLBWOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  ethyl-malonic acid bis-methylamide 在 tetraphosphorus decasulfide 作用下， 以 甲苯 为溶剂， 生成 Ethyl-dithiomalonsaeure-bis-methylamid
  参考文献：
  名称：

  Radiation-protection properties of 1,2-dithiolium derivatives

  摘要：

  DOI：

  10.1007/bf00771581
• 作为产物：
  描述：

  乙基丙二酸二乙酯 、 甲胺 生成 ethyl-malonic acid bis-methylamide
  参考文献：
  名称：

  West, Journal of the Chemical Society, 1924, vol. 125, p. 717,720

  摘要：

  DOI：

文献信息

• Schey, Recueil des Travaux Chimiques des Pays-Bas, 1897, vol. 16, p. 357
  作者：Schey

  DOI：——

  日期：——
• Methods of preparing polymers having terminal amine groups
  申请人：Zhao Hong

  公开号：US20070049725A1

  公开（公告）日：2007-03-01

  The present invention is directed to methods of preparing linear polymers such as polyalkylene oxides containing a terminal amine in high purity. One preferred method includes reacting a polyalkylene oxide such as polyethylene glycol containing a terminal azide with a phosphine-based reducing agent such as triphenylphosphine or an alkali metal borohydride reducing agent such as sodium borohydride in a solvent to reflux. The resultant polymer-amines are of sufficient purity so that expensive and time consuming purification steps required for pharmaceutical grade polymers are avoided.
• RECOMBINANT HOST FOR PRODUCING L-ASPARAGINASE II
  申请人：Filpula Ray David

  公开号：US20080063632A1

  公开（公告）日：2008-03-13

  The invention provides a recombinant Escherichia coli host cell for producing an Escherichia coli -asparaginase II enzyme. The host cell includes an Escherichia coli chromosome and at least one copy of a recombinant extrachromosomal vector, wherein the recombinant extrachromosomal vector encodes the L-asparaginase II enzyme, wherein the host cell chromosome also encodes the same L-asparaginase II enzyme, and wherein the host chromosome does not encode any other isoform of L-asparaginase II.
• Polymer-Linked Pseudomonas Exotoxin Immunotoxin
  申请人：Filpula David Ray

  公开号：US20080125363A1

  公开（公告）日：2008-05-29

  The present invention relates to polymer conjugates of SS1P, and methods of making using the same.
• RELEASABLE POLYMERIC CONJUGATES BASED ON ALIPHATIC BIODEGRADABLE LINKERS
  申请人：ZHAO Hong

  公开号：US20080305070A1

  公开（公告）日：2008-12-11

  Activated polymeric bicine derivatives such as, as well as conjugates made therewith are disclosed. Methods of making and using the bicine derivatives are also disclosed.