N-(p-Cyanophenyl)-p-chlorobenzenesulfonamide | 134899-80-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(p-Cyanophenyl)-p-chlorobenzenesulfonamide
• 英文别名: 4-chloro-4'-cyano-benzenesulfonanilide；4-chloro-4'-cyanobenzenesulfonamide；4-Chloro-4'-cyanobenzenesulfonanilide；4-chloro-N-(4-cyanophenyl)benzenesulfonamide
• CAS: 134899-80-2
• 化学式: C₁₃H₉ClN₂O₂S
• 分子量: 292.746
• InChiKey: HVCPJOCZSIIYFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(p-Cyanophenyl)-p-chlorobenzenesulfonamide 在 硝酸 作用下， 以 乙酸酐 为溶剂， 以4.30 g (93%)的产率得到4-chloro-4'-cyano-2'-nitrobenzenesulfonanilide
  参考文献：
  名称：

  Sulfonamide derivatives

  摘要：

  本发明涉及包含磺酰胺衍生物的用于农业或园艺的杀微生物剂。

  公开号：

  US06586617B1
• 作为产物：
  描述：

  氯苯 、 alkaline earth salt of/the/ methylsulfuric acid 在 吡啶 、 chlorosulphuric acid 作用下， 反应 0.08h， 生成 N-(p-Cyanophenyl)-p-chlorobenzenesulfonamide
  参考文献：
  名称：

  Effect of para Substitution on Dissociation of N-Phenylbenzenesulfonamides

  摘要：

  替代苯胺和苯磺酰氯的反应已被用于制备49种通式为4-X-C₆H₄SO₂NHC₆H₄-Y-4'的取代N-苯基苯磺酰胺。它们的纯度通过元素分析进行了检查。取代基X和Y包括H、CH₃、CH₃O、Cl、Br、CN和NO₂。所有化合物的解离常数通过在甲醇、乙腈、N,N-二甲基甲酰胺和吡啶中的电位滴定确定。获得的解离常数pKHA与各种取代基常数相关联。发现取代基X和Y对解离的影响最好通过使用带有σp常数的Hammett方程和带有σp-和σp常数的Yukawa-Tsuno方程来描述。这一结果证实了Y取代基与反应中心的直接共轭。在所有使用的溶剂中，使用加性模型解释的可变性超过96%。数据还提供了关于SO₂基团的传输效应的信息。平均解离常数进一步通过潜在变量方法、主成分和共轭偏差分析进行处理。

  DOI：

  10.1135/cccc20041479

文献信息

• 8,8A-DIHYDROINDENO[1,2-D]THIAZOLE DERIVATIVES WHICH CARRY IN THE 2-POSITION A SUBSTITUENT HAVING A SULFONAMIDE STRUCTURE OR SULFONE STRUCTURE; PROCESSES FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
  申请人：Aventis Pharma Deutschland GmbH

  公开号：US06352987B2

  公开（公告）日：2002-03-05

  8,8a-Dihydroindeno[1,2-d]thiazole derivatives which carry in the 2-position a substituent having a sulfonamide structure or sulfone structure; processes for their preparation and their use as medicaments The invention relates to polycyclic dihydrothiazoles and to their physiologically acceptable salts and physiologically functional derivatives. Compounds of formula I, in which the radicals are as defined above, and their physiologically acceptable salts and processes for their preparation are described. The compounds are suitable, for example, as anorectics.

  8,8a-二氢吲哚并［1,2-d］噻唑衍生物，其在2-位置携带有磺胺酰胺结构或磺酰结构的取代基；它们的制备方法及其用作药物的用途。该发明涉及多环二氢噻唑及其生理上可接受的盐和生理功能衍生物。描述了式I的化合物，其中基团如上所定义，以及它们的生理上可接受的盐和制备方法。这些化合物适用于例如作为压食剂。
• Amidines. VIII. A kinetic study of alcoholysis of N1-arenesulfonyl-N1,N2-diarylacetamidines.
  作者：Machiko ONO、Reiko TODORIKI、Shinzo TAMURA

  DOI：10.1248/cpb.39.558

  日期：——

  Alcoholysis of N1-Arenesulfonyl-N1, N2-diarylacetamidines (1-30) was studied kinetically. The rate of the reaction between the substrates and ethoxide ion depended on the electron-withdrawing resonance effect of the substituents on both the N1-aryl and N2-aryl groups to a similar extent. The rate of the neutral alcoholysis depended on the resonance effect of the N1-aryl substituent to a larger extent than in the former reaction, and depended hardly at all on the electron-releasing resonance effect of the N2-aryl substituent, showing that the reaction does not proceed by the solvolysis mechanism.A reaction mechanism is proposed in which the rate-determining attack of the nucleophile is accompanied by the concerted departure of the N-arylarenesulfonamide group.

  对 N1-壬磺酰基-N1，N2-二芳基乙酰胺（1-30）的醇解进行了动力学研究。底物与乙氧离子的反应速率在类似程度上取决于 N1 芳基和 N2 芳基上取代基的吸电子共振效应。与前一种反应相比，中性醇解反应的速率在更大程度上取决于 N1-芳基取代基的共振效应，而几乎不取决于 N2-芳基取代基的电子释放共振效应，这表明该反应不是通过溶解机理进行的。
• 8,8a-dihydroindeno[1,2-d]thiazole derivatives which carry in the 2-position a substituent having a sulfonamide structure or sulfone structure; processes for their preparation and their use as medicaments
  申请人：——

  公开号：US20010039278A1

  公开（公告）日：2001-11-08

  8,8a-Dihydroindeno[1,2-d]thiazole derivatives which carry in the 2-position a substituent having a sulfonamide structure or sulfone structure; processes for their preparation and their use as medicaments The invention relates to polycyclic dihydrothiazoles and to their physiologically acceptable salts and physiologically functional derivatives. Compounds of formula I, 1 in which the radicals are as defined above, and their physiologically acceptable salts and processes for their preparation are described. The compounds are suitable, for example, as anorectics.

  8,8a-二氢吲哚并[1,2-d]噻唑衍生物，其中在2-位携带有磺酰胺结构或砜结构的取代基；它们的制备方法以及它们作为药物的用途。该发明涉及多环二氢噻唑及其生理上可接受的盐和生理功能衍生物。描述了式I,1中的化合物，其中基团如上所定义，以及它们的生理上可接受的盐和制备方法。这些化合物适用于例如作为厌食症药物。
• SULFONAMIDE DERIVATIVES
  申请人：Sumitomo Chemical Takeda Agro Company, Limited

  公开号：EP1174028B1

  公开（公告）日：2004-12-22
• US6586617B1
  申请人：——

  公开号：US6586617B1

  公开（公告）日：2003-07-01