N-(2,4-Difluoro-phenyl)-3-methyl-4-nitro-thiobenzamide | 343975-40-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2,4-Difluoro-phenyl)-3-methyl-4-nitro-thiobenzamide
• 英文别名: N-(2,4-difluorophenyl)-3-methyl-4-nitrobenzenecarbothioamide
• CAS: 343975-40-6
• 化学式: C₁₄H₁₀F₂N₂O₂S
• 分子量: 308.308
• InChiKey: DQNBSTIWSGKIPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  89.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-(2,4-Difluoro-phenyl)-3-methyl-4-nitro-thiobenzamide 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 二氯甲烷 为溶剂， 反应 0.33h， 以85%的产率得到4,6-Difluoro-2-(3-methyl-4-nitro-phenyl)-benzothiazole
  参考文献：
  名称：

  Synthesis of 2-Arylbenzothiazoles by DDQ-Promoted Cyclization of Thioformanilides; A Solution-Phase Strategy for Library Synthesis

  摘要：

  数种取代苯并噻唑通过分子内环化，在高产率下合成，以硫代酰胺与2,6-二氯-3,5-二氰基-1,4-苯醌（DDQ）在二氯甲烷中室温反应。所得到的2-芳基苯并噻唑可通过用强碱性离子交换树脂处理反应混合物，从还原型DDQ副产物（4,5-二氯-3,6-二羟基邻苯二腈）中分离出来。本方法在苯并噻唑环或2-芳基部分上引入官能团具有高度的灵活性，进而为平行合成提供了骨架。

  DOI：

  10.1055/s-2007-965929
• 作为产物：
  描述：

  3-甲基-4-硝基苯甲酰氯 在 劳森试剂 、 三乙胺 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 生成 N-(2,4-Difluoro-phenyl)-3-methyl-4-nitro-thiobenzamide
  参考文献：
  名称：

  Synthesis of 2-Arylbenzothiazoles by DDQ-Promoted Cyclization of Thioformanilides; A Solution-Phase Strategy for Library Synthesis

  摘要：

  数种取代苯并噻唑通过分子内环化，在高产率下合成，以硫代酰胺与2,6-二氯-3,5-二氰基-1,4-苯醌（DDQ）在二氯甲烷中室温反应。所得到的2-芳基苯并噻唑可通过用强碱性离子交换树脂处理反应混合物，从还原型DDQ副产物（4,5-二氯-3,6-二羟基邻苯二腈）中分离出来。本方法在苯并噻唑环或2-芳基部分上引入官能团具有高度的灵活性，进而为平行合成提供了骨架。

  DOI：

  10.1055/s-2007-965929

文献信息

• Antitumor Benzothiazoles. 14. Synthesis and in Vitro Biological Properties of Fluorinated 2-(4-Aminophenyl)benzothiazoles
  作者：Ian Hutchinson、Mei-Sze Chua、Helen L. Browne、Valentina Trapani、Tracey D. Bradshaw、Andrew D. Westwell、Malcolm F. G. Stevens

  DOI：10.1021/jm001104n

  日期：2001.4.1

  Synthetic routes to a series of mono- and difluorinated 2-(4-amino-3-substituted-phenyl)benzothiazoles have been devised. Whereas mixtures of regioisomeric 5- and 7-fluorobenzothiazoles were formed from the established Jacobsen cyclization of precursor 3-fluorothiobenzanilides, two modifications to this general process have allowed the synthesis of pure samples of these target compounds. Fluorinated 2-(4-aminophenyl)benzothiazoles were potently cytotoxic (GI(50) < 1 nM) in vitro in sensitive human breast MCF-7 (ER+) and MDA 468 (ER-) cell lines but inactive (GI(50) > 10 muM) against PC 3 prostate, nonmalignant HBL 100 breast, and HCT 116 colon cells. The biphasic dose-response relationship characteristically shown by the benzothiazole series against sensitive cell lines was exhibited by the 4- and 6-fluorobenzothiazoles (10b,d) but not by the 5- and 7-fluoro-benzothiazoles (10h,i). The most potent broad spectrum agent in the NCI cell panel was 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (10h) which, unlike the g-fluoro isomer (10d), produces no exportable metabolites in the presence of sensitive MCF-7 cells. Induction of cytochrome P450 CYP1A1, a crucial event in determining the antitumor specificity of this series of benzothiazoles, was not compromised. 10h is currently the focus of pharmaceutical and preclinical development.
• Synthesis of 2-Arylbenzothiazoles by DDQ-Promoted Cyclization of Thioformanilides; A Solution-Phase Strategy for Library Synthesis
  作者：D. Bose、Mohd. Idrees、Bingi Srikanth

  DOI：10.1055/s-2007-965929

  日期：2007.3

  Several substituted benzothiazoles were synthesized by the intramolecular cyclization of thioformanilides using 2,6-dichloro-3,5-dicyano-1,4-benzoquinone (DDQ) in dichloromethane at ambient temperature in high yields. The resulting 2-arylbenzothi­azoles were separated from the reduced DDQ byproduct 4,5-dichloro-3,6-dihydroxyphthalonitrile by treatment of the reaction mixture with a strongly basic ion-exchange resin. This protocol offers a high degree of flexibility with regard to the functional groups that can be placed on the benzothiazole ring or 2-aryl moiety, which in turn generates scaffolds for parallel synthesis.

  数种取代苯并噻唑通过分子内环化，在高产率下合成，以硫代酰胺与2,6-二氯-3,5-二氰基-1,4-苯醌（DDQ）在二氯甲烷中室温反应。所得到的2-芳基苯并噻唑可通过用强碱性离子交换树脂处理反应混合物，从还原型DDQ副产物（4,5-二氯-3,6-二羟基邻苯二腈）中分离出来。本方法在苯并噻唑环或2-芳基部分上引入官能团具有高度的灵活性，进而为平行合成提供了骨架。
• A convenient access to substituted benzothiazole scaffolds via intramolecular cyclization of thioformanilides
  作者：D. Subhas Bose、Mohd. Idrees

  DOI：10.1016/j.tetlet.2006.11.105

  日期：2007.1

  A new and practical method has been developed for the synthesis of substituted benzothiazoles via the intramolecular cyclization of thioformanilides using DDQ in CH2Cl2 at ambient temperature. The reaction proceeds in high yields via the thiyl radical to give novel oxybis-benzothiazole, and offers a high degree of flexibility with regard to the functional groups that can be placed on the benzothiazole

  已经开发了一种新的实用方法，用于在环境温度下使用DDQ在CH 2 Cl 2中通过硫代甲酰苯胺的分子内环化来合成取代的苯并噻唑。该反应通过噻吩基团以高收率进行，从而得到新型的氧双-苯并噻唑，并且对于可置于苯并噻唑核或2-芳基部分上的官能团提供了高度的灵活性，从而又生成了平行的支架合成。